ENSG00000108061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369452 ENSG00000108061 HEK293_OSMI2_2hA HEK293_TMG_2hB SHOC2 protein_coding protein_coding 8.135756 1.62887 14.73283 0.335711 0.8519675 3.16924 2.72312496 0.7014841 4.6182845 0.3621857 0.44795901 2.701574 0.53790000 0.4635667 0.31680000 -0.14676667 9.742918e-01 4.453664e-26 FALSE TRUE
ENST00000489783 ENSG00000108061 HEK293_OSMI2_2hA HEK293_TMG_2hB SHOC2 protein_coding processed_transcript 8.135756 1.62887 14.73283 0.335711 0.8519675 3.16924 0.87707617 0.0000000 1.2453063 0.0000000 0.63739358 6.971896 0.06155000 0.0000000 0.07983333 0.07983333 5.015938e-01 4.453664e-26 FALSE FALSE
ENST00000689118 ENSG00000108061 HEK293_OSMI2_2hA HEK293_TMG_2hB SHOC2 protein_coding protein_coding 8.135756 1.62887 14.73283 0.335711 0.8519675 3.16924 0.05320032 0.3802472 0.0000000 0.3802472 0.00000000 -5.286317 0.03469583 0.2744667 0.00000000 -0.27446667 5.599299e-01 4.453664e-26 FALSE TRUE
ENST00000689997 ENSG00000108061 HEK293_OSMI2_2hA HEK293_TMG_2hB SHOC2 protein_coding protein_coding 8.135756 1.62887 14.73283 0.335711 0.8519675 3.16924 0.19926790 0.3768453 0.1793446 0.3768453 0.03201923 -1.030742 0.03260833 0.1643667 0.01253333 -0.15183333 8.672435e-01 4.453664e-26 FALSE TRUE
ENST00000692776 ENSG00000108061 HEK293_OSMI2_2hA HEK293_TMG_2hB SHOC2 protein_coding protein_coding 8.135756 1.62887 14.73283 0.335711 0.8519675 3.16924 3.77771208 0.0000000 7.1716214 0.0000000 0.35355991 9.488166 0.26121250 0.0000000 0.48750000 0.48750000 4.453664e-26 4.453664e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108061 E001 0.0000000       10 110919367 110919441 75 +      
ENSG00000108061 E002 0.1515154 0.0442574496 1.000000e+00   10 110919575 110919575 1 + 0.047 0.000 -8.919
ENSG00000108061 E003 0.4482035 0.0270529442 1.000000e+00 1.000000e+00 10 110919576 110919587 12 + 0.127 0.000 -11.873
ENSG00000108061 E004 0.4482035 0.0270529442 1.000000e+00 1.000000e+00 10 110919588 110919588 1 + 0.127 0.000 -11.873
ENSG00000108061 E005 0.7406253 0.0154027213 4.461752e-01 5.876919e-01 10 110919589 110919590 2 + 0.195 0.000 -12.625
ENSG00000108061 E006 0.7406253 0.0154027213 4.461752e-01 5.876919e-01 10 110919591 110919592 2 + 0.195 0.000 -12.625
ENSG00000108061 E007 1.0330470 0.0118653645 2.608481e-01 3.984270e-01 10 110919593 110919599 7 + 0.254 0.000 -13.084
ENSG00000108061 E008 1.2544922 0.0105347943 8.006962e-01 8.729678e-01 10 110919600 110919602 3 + 0.254 0.286 0.229
ENSG00000108061 E009 1.5469139 0.0086088861 5.887535e-01 7.119296e-01 10 110919603 110919603 1 + 0.306 0.286 -0.134
ENSG00000108061 E010 1.6984293 0.0081978528 5.057461e-01 6.414799e-01 10 110919604 110919606 3 + 0.330 0.286 -0.286
ENSG00000108061 E011 9.3883433 0.0018350293 9.989616e-05 5.213506e-04 10 110919607 110919618 12 + 0.906 0.286 -2.919
ENSG00000108061 E012 23.6249576 0.0037625180 2.559332e-07 2.402085e-06 10 110919619 110919657 39 + 1.267 0.753 -1.910
ENSG00000108061 E013 0.0000000       10 110920003 110920146 144 +      
ENSG00000108061 E014 0.5180316 0.0217681645 1.847182e-03 6.749665e-03 10 110920897 110920974 78 + 0.000 0.579 15.561
ENSG00000108061 E015 0.1472490 0.0456932995 1.000000e+00   10 110941377 110941474 98 + 0.047 0.000 -10.232
ENSG00000108061 E016 3.8014457 0.0600161263 9.764313e-01 9.892613e-01 10 110951608 110951790 183 + 0.531 0.673 0.630
ENSG00000108061 E017 2.3784863 0.0074759199 7.975927e-01 8.708665e-01 10 110951791 110951792 2 + 0.394 0.579 0.917
ENSG00000108061 E018 0.0000000       10 110955416 110955466 51 +      
ENSG00000108061 E019 219.3075257 0.0003444366 1.370920e-31 2.556267e-29 10 110964125 110965031 907 + 2.194 1.952 -0.811
ENSG00000108061 E020 38.5549652 0.0005409078 5.827025e-05 3.229419e-04 10 110965032 110965061 30 + 1.446 1.293 -0.532
ENSG00000108061 E021 0.4355181 0.6217593175 1.000000e+00 1.000000e+00 10 110965062 110967161 2100 + 0.127 0.000 -10.999
ENSG00000108061 E022 0.2924217 0.0275823625 1.000000e+00   10 110967162 110967278 117 + 0.089 0.000 -11.307
ENSG00000108061 E023 0.1472490 0.0456932995 1.000000e+00   10 110967279 110970194 2916 + 0.047 0.000 -10.232
ENSG00000108061 E024 0.0000000       10 110982796 110983439 644 +      
ENSG00000108061 E025 75.5812723 0.0004904131 3.538092e-06 2.606752e-05 10 110985628 110985765 138 + 1.723 1.642 -0.275
ENSG00000108061 E026 0.1515154 0.0442574496 1.000000e+00   10 110985766 110985922 157 + 0.047 0.000 -10.240
ENSG00000108061 E027 83.1840560 0.0003048908 9.974747e-05 5.206607e-04 10 111000415 111000545 131 + 1.756 1.741 -0.053
ENSG00000108061 E028 101.5536558 0.0003436726 1.012683e-03 4.002457e-03 10 111004606 111004794 189 + 1.834 1.873 0.131
ENSG00000108061 E029 80.4808457 0.0003285214 5.507924e-04 2.349658e-03 10 111007531 111007653 123 + 1.740 1.748 0.025
ENSG00000108061 E030 74.8042202 0.0005958543 4.731616e-03 1.518251e-02 10 111009248 111009385 138 + 1.705 1.741 0.121
ENSG00000108061 E031 0.0000000       10 111009386 111009712 327 +      
ENSG00000108061 E032 88.0091000 0.0003393177 9.694218e-02 1.858164e-01 10 111009713 111009830 118 + 1.763 1.878 0.388
ENSG00000108061 E033 0.5954526 0.0172671820 6.106860e-01 7.299820e-01 10 111009831 111010565 735 + 0.163 0.000 -12.316
ENSG00000108061 E034 468.9948100 0.0140547524 6.237425e-16 2.420941e-14 10 111011610 111017307 5698 + 2.397 2.884 1.620