ENSG00000108039

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000502935 ENSG00000108039 HEK293_OSMI2_2hA HEK293_TMG_2hB XPNPEP1 protein_coding protein_coding 49.05461 57.34612 45.31505 7.459927 0.8791118 -0.3396389 35.84084 42.49517 35.670684 6.453476 0.7106345 -0.252495 0.7291708 0.7361333 0.78740000 0.05126667 3.352022e-01 1.270916e-06 FALSE  
MSTRG.4620.5 ENSG00000108039 HEK293_OSMI2_2hA HEK293_TMG_2hB XPNPEP1 protein_coding   49.05461 57.34612 45.31505 7.459927 0.8791118 -0.3396389 6.96833 10.09404 3.658559 1.374678 0.3059006 -1.461648 0.1407000 0.1761333 0.08093333 -0.09520000 1.270916e-06 1.270916e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108039 E001 9.9092170 0.0016887590 1.699952e-03 6.283429e-03 10 109864766 109864769 4 - 0.760 1.132 1.401
ENSG00000108039 E002 426.1880524 0.0044078613 4.249353e-07 3.812366e-06 10 109864770 109865053 284 - 2.483 2.676 0.642
ENSG00000108039 E003 704.7225583 0.0019516912 1.135662e-09 1.666384e-08 10 109865054 109865312 259 - 2.728 2.884 0.518
ENSG00000108039 E004 313.4970303 0.0007344718 1.950464e-05 1.213257e-04 10 109868614 109868635 22 - 2.412 2.523 0.372
ENSG00000108039 E005 429.2748866 0.0003202887 3.920934e-07 3.540221e-06 10 109868636 109868712 77 - 2.552 2.659 0.356
ENSG00000108039 E006 397.1791067 0.0002067941 1.077731e-05 7.107603e-05 10 109869953 109870029 77 - 2.527 2.621 0.313
ENSG00000108039 E007 579.5130011 0.0001223269 1.016374e-06 8.416703e-06 10 109870731 109870904 174 - 2.697 2.782 0.286
ENSG00000108039 E008 3.4792783 0.0948223636 6.655471e-01 7.732059e-01 10 109870905 109871032 128 - 0.577 0.655 0.340
ENSG00000108039 E009 1.7349584 0.0298108902 5.553658e-01 6.842415e-01 10 109871789 109871791 3 - 0.474 0.370 -0.560
ENSG00000108039 E010 235.6497872 0.0004686009 5.701747e-01 6.966739e-01 10 109871792 109871795 4 - 2.350 2.375 0.082
ENSG00000108039 E011 387.7256986 0.0002012068 2.557768e-01 3.927040e-01 10 109871796 109871861 66 - 2.560 2.592 0.105
ENSG00000108039 E012 387.6876102 0.0002209453 6.205329e-01 7.376889e-01 10 109873367 109873427 61 - 2.580 2.580 0.000
ENSG00000108039 E013 3.9343934 0.0047130562 4.546268e-02 1.010449e-01 10 109873428 109873577 150 - 0.841 0.565 -1.153
ENSG00000108039 E014 1.1028881 0.0112770669 3.591212e-01 5.034553e-01 10 109875524 109875527 4 - 0.412 0.256 -0.983
ENSG00000108039 E015 330.6266910 0.0001437166 1.458726e-02 3.956241e-02 10 109875528 109875599 72 - 2.535 2.495 -0.132
ENSG00000108039 E016 88.4310899 0.0041835104 1.792838e-03 6.576841e-03 10 109875600 109877553 1954 - 2.027 1.879 -0.498
ENSG00000108039 E017 8.1655247 0.0549421999 1.050228e-01 1.981209e-01 10 109877554 109877676 123 - 1.082 0.853 -0.857
ENSG00000108039 E018 5.8563955 0.0418257771 2.468630e-02 6.123798e-02 10 109877677 109877722 46 - 1.005 0.675 -1.286
ENSG00000108039 E019 10.5332855 0.0017322922 8.717227e-03 2.558051e-02 10 109877723 109877789 67 - 1.195 0.942 -0.919
ENSG00000108039 E020 349.3452495 0.0001596486 1.072892e-02 3.051940e-02 10 109877790 109877867 78 - 2.560 2.519 -0.135
ENSG00000108039 E021 287.9622047 0.0010321983 6.115536e-01 7.306547e-01 10 109878000 109878058 59 - 2.453 2.447 -0.020
ENSG00000108039 E022 1.8415362 0.2132277918 3.024093e-01 4.442780e-01 10 109878059 109878369 311 - 0.577 0.322 -1.333
ENSG00000108039 E023 243.8670078 0.0004977185 8.607662e-01 9.141863e-01 10 109880188 109880238 51 - 2.369 2.381 0.041
ENSG00000108039 E024 236.5828675 0.0002854046 9.106258e-01 9.471943e-01 10 109880842 109880872 31 - 2.356 2.368 0.038
ENSG00000108039 E025 179.4493249 0.0003490976 5.783641e-01 7.034725e-01 10 109880873 109880877 5 - 2.249 2.242 -0.023
ENSG00000108039 E026 267.0609356 0.0001721369 7.551469e-01 8.405671e-01 10 109880878 109880931 54 - 2.416 2.418 0.008
ENSG00000108039 E027 170.9975314 0.0009944093 9.460590e-01 9.701374e-01 10 109882432 109882434 3 - 2.217 2.227 0.032
ENSG00000108039 E028 310.9527240 0.0001478056 7.622630e-01 8.458898e-01 10 109882435 109882523 89 - 2.474 2.490 0.053
ENSG00000108039 E029 202.3758426 0.0015389356 9.471146e-01 9.707854e-01 10 109882524 109882547 24 - 2.293 2.299 0.020
ENSG00000108039 E030 228.4781738 0.0021019355 7.708161e-01 8.520430e-01 10 109882548 109882592 45 - 2.338 2.354 0.053
ENSG00000108039 E031 163.2526794 0.0004106586 8.406224e-01 9.005253e-01 10 109882593 109882600 8 - 2.204 2.208 0.013
ENSG00000108039 E032 213.1092074 0.0016856019 5.417466e-01 6.726840e-01 10 109882601 109882642 42 - 2.302 2.330 0.095
ENSG00000108039 E033 0.3030308 0.4003129396 1.961937e-01   10 109883788 109884065 278 - 0.254 0.000 -12.762
ENSG00000108039 E034 0.4804688 0.0211256003 3.572764e-01 5.016820e-01 10 109884066 109884066 1 - 0.253 0.103 -1.567
ENSG00000108039 E035 206.9444240 0.0004163897 9.577756e-01 9.775330e-01 10 109884067 109884105 39 - 2.301 2.311 0.035
ENSG00000108039 E036 202.5397840 0.0002001220 4.129738e-01 5.565197e-01 10 109884106 109884124 19 - 2.278 2.308 0.102
ENSG00000108039 E037 210.0974148 0.0008366628 1.535704e-01 2.665261e-01 10 109884125 109884148 24 - 2.332 2.298 -0.115
ENSG00000108039 E038 0.7728880 0.0210708821 8.791654e-02 1.719599e-01 10 109884149 109884272 124 - 0.000 0.316 12.349
ENSG00000108039 E039 0.1451727 0.0442632075 3.387295e-01   10 109884493 109884539 47 - 0.145 0.000 -11.755
ENSG00000108039 E040 211.2676694 0.0004792036 9.885975e-02 1.887363e-01 10 109886246 109886265 20 - 2.336 2.300 -0.121
ENSG00000108039 E041 180.2912768 0.0002213974 4.688271e-02 1.036200e-01 10 109886266 109886269 4 - 2.274 2.229 -0.150
ENSG00000108039 E042 303.1310699 0.0005985286 1.801427e-01 3.013493e-01 10 109886270 109886341 72 - 2.486 2.461 -0.081
ENSG00000108039 E043 279.3125480 0.0010292877 2.286025e-02 5.744918e-02 10 109888049 109888097 49 - 2.468 2.415 -0.175
ENSG00000108039 E044 335.3236049 0.0019257364 9.074728e-02 1.763117e-01 10 109888098 109888192 95 - 2.540 2.497 -0.146
ENSG00000108039 E045 0.1482932 0.0405960534 6.863026e-01   10 109888496 109888502 7 - 0.000 0.103 10.343
ENSG00000108039 E046 295.4022746 0.0010085065 8.136544e-02 1.616939e-01 10 109888503 109888595 93 - 2.483 2.446 -0.124
ENSG00000108039 E047 0.3299976 0.0274424043 3.355486e-01   10 109891266 109891354 89 - 0.000 0.186 11.345
ENSG00000108039 E048 1.1146300 0.0379121912 1.064916e-01 2.003786e-01 10 109891579 109891719 141 - 0.474 0.186 -1.889
ENSG00000108039 E049 2.0888299 0.2049352338 7.082882e-01 8.059915e-01 10 109891720 109891721 2 - 0.528 0.456 -0.355
ENSG00000108039 E050 329.3415810 0.0004906029 1.767566e-04 8.643666e-04 10 109891722 109891826 105 - 2.554 2.480 -0.247
ENSG00000108039 E051 0.0000000       10 109892489 109892584 96 -      
ENSG00000108039 E052 277.5344179 0.0002114475 3.222071e-08 3.606569e-07 10 109893012 109893075 64 - 2.503 2.391 -0.373
ENSG00000108039 E053 1.1156622 0.0123274366 1.328401e-02 3.657969e-02 10 109893076 109893369 294 - 0.529 0.103 -3.151
ENSG00000108039 E054 0.0000000       10 109893370 109893493 124 -      
ENSG00000108039 E055 0.2955422 0.0286254540 7.623217e-01   10 109894016 109894110 95 - 0.145 0.103 -0.569
ENSG00000108039 E056 361.1063672 0.0006486772 1.546890e-06 1.232665e-05 10 109907691 109907815 125 - 2.607 2.508 -0.329
ENSG00000108039 E057 0.6287620 0.0172671820 6.798515e-01 7.839255e-01 10 109907816 109907819 4 - 0.253 0.186 -0.568
ENSG00000108039 E058 156.1704790 0.0002950534 6.086509e-10 9.399012e-09 10 109915011 109915022 12 - 2.286 2.117 -0.566
ENSG00000108039 E059 222.5625378 0.0002066653 1.136827e-14 3.709412e-13 10 109915023 109915099 77 - 2.443 2.266 -0.590
ENSG00000108039 E060 0.3697384 0.0254945254 3.327187e-01 4.763933e-01 10 109915100 109915179 80 - 0.000 0.186 11.347
ENSG00000108039 E061 1.1019577 0.1737507263 1.610276e-01 2.764564e-01 10 109923209 109923401 193 - 0.474 0.187 -1.883
ENSG00000108039 E062 165.0044353 0.0039768478 6.233454e-04 2.618191e-03 10 109923402 109923584 183 - 2.288 2.151 -0.459