ENSG00000108010

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331244 ENSG00000108010 HEK293_OSMI2_2hA HEK293_TMG_2hB GLRX3 protein_coding protein_coding 105.7217 74.14462 143.9079 11.01445 4.8757 0.9566378 93.065475 60.306904 129.979554 8.295676 4.028389 1.1077614 0.861900 0.8157667 0.90346667 0.08770000 0.0002696648 0.0002696648 FALSE  
MSTRG.4820.3 ENSG00000108010 HEK293_OSMI2_2hA HEK293_TMG_2hB GLRX3 protein_coding   105.7217 74.14462 143.9079 11.01445 4.8757 0.9566378 9.167476 9.926059 9.260369 2.006935 1.947287 -0.1000471 0.097025 0.1320000 0.06396667 -0.06803333 0.0156491854 0.0002696648 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108010 E001 0.3289534 2.773312e-02 7.668796e-01   10 130136227 130136351 125 + 0.102 0.146 0.593
ENSG00000108010 E002 4.2008660 1.450183e-02 3.657791e-01 5.100827e-01 10 130136352 130136390 39 + 0.761 0.624 -0.573
ENSG00000108010 E003 10.8880971 2.140533e-02 6.680740e-01 7.751432e-01 10 130136391 130136398 8 + 1.054 1.099 0.165
ENSG00000108010 E004 355.6750163 1.700455e-03 1.163342e-02 3.266005e-02 10 130136399 130136512 114 + 2.583 2.510 -0.245
ENSG00000108010 E005 600.6191620 1.027061e-03 7.413993e-02 1.501672e-01 10 130145211 130145319 109 + 2.797 2.757 -0.133
ENSG00000108010 E006 1.1782197 1.086478e-02 8.721042e-03 2.558973e-02 10 130159746 130159834 89 + 0.494 0.000 -10.918
ENSG00000108010 E007 580.1807696 1.458128e-04 5.767332e-05 3.199800e-04 10 130159995 130160069 75 + 2.791 2.734 -0.190
ENSG00000108010 E008 1080.4987479 5.573131e-04 1.512148e-02 4.076208e-02 10 130160796 130160997 202 + 3.051 3.014 -0.123
ENSG00000108010 E009 1088.0556301 2.949389e-04 2.243850e-02 5.659122e-02 10 130166507 130166679 173 + 3.051 3.024 -0.090
ENSG00000108010 E010 787.3217434 1.146115e-03 4.956517e-02 1.083905e-01 10 130166919 130166980 62 + 2.915 2.877 -0.125
ENSG00000108010 E011 811.4949972 1.686728e-04 4.354575e-03 1.413452e-02 10 130169433 130169490 58 + 2.928 2.895 -0.110
ENSG00000108010 E012 792.3473877 8.879597e-05 1.601274e-02 4.276481e-02 10 130171584 130171636 53 + 2.914 2.889 -0.083
ENSG00000108010 E013 696.2547880 9.677585e-05 7.839502e-02 1.569118e-01 10 130174867 130174906 40 + 2.855 2.837 -0.060
ENSG00000108010 E014 943.2655326 1.146879e-04 3.286578e-02 7.753827e-02 10 130174997 130175089 93 + 2.965 2.996 0.105
ENSG00000108010 E015 588.9760939 8.054403e-04 2.650653e-04 1.237483e-03 10 130179342 130179373 32 + 2.738 2.814 0.252
ENSG00000108010 E016 590.0848822 1.057660e-03 3.503740e-05 2.048239e-04 10 130179374 130179420 47 + 2.732 2.822 0.301
ENSG00000108010 E017 298.9709962 5.524593e-04 9.852632e-02 1.882439e-01 10 130179421 130179672 252 + 2.461 2.505 0.148
ENSG00000108010 E018 170.6846274 5.253577e-03 3.289701e-11 6.292651e-10 10 130180113 130180184 72 + 2.076 2.382 1.024
ENSG00000108010 E019 145.3698768 4.316563e-03 2.791440e-11 5.406153e-10 10 130180185 130180321 137 + 2.010 2.311 1.007
ENSG00000108010 E020 107.3598614 5.721249e-03 7.047710e-06 4.850569e-05 10 130180322 130182881 2560 + 1.919 2.157 0.798
ENSG00000108010 E021 1.4016514 4.180475e-02 4.027941e-01 5.465886e-01 10 130183281 130183284 4 + 0.314 0.475 0.906
ENSG00000108010 E022 10.4320645 8.460612e-03 4.239063e-03 1.381116e-02 10 130183285 130183644 360 + 0.897 1.217 1.168
ENSG00000108010 E023 10.0413971 8.847071e-03 4.195173e-02 9.463853e-02 10 130183868 130184521 654 + 0.925 1.152 0.829