ENSG00000108001

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355311 ENSG00000108001 HEK293_OSMI2_2hA HEK293_TMG_2hB EBF3 protein_coding protein_coding 6.781995 4.353954 9.249977 0.5797995 0.1704334 1.085373 0.3350410 0.0000000 0.7825074 0.00000000 0.1290295 6.3083526 0.03724167 0.00000000 0.08420000 0.084200000 3.700993e-07 3.700993e-07 FALSE TRUE
ENST00000368648 ENSG00000108001 HEK293_OSMI2_2hA HEK293_TMG_2hB EBF3 protein_coding protein_coding 6.781995 4.353954 9.249977 0.5797995 0.1704334 1.085373 2.5320274 2.5015556 3.2870683 0.27969835 0.2812572 0.3926026 0.40527083 0.57756667 0.35620000 -0.221366667 2.205534e-03 3.700993e-07 FALSE TRUE
ENST00000440978 ENSG00000108001 HEK293_OSMI2_2hA HEK293_TMG_2hB EBF3 protein_coding protein_coding 6.781995 4.353954 9.249977 0.5797995 0.1704334 1.085373 1.6582690 1.2392554 1.8569256 0.29737649 0.2079372 0.5795959 0.25492500 0.27766667 0.20163333 -0.076033333 4.000034e-01 3.700993e-07 FALSE TRUE
ENST00000675373 ENSG00000108001 HEK293_OSMI2_2hA HEK293_TMG_2hB EBF3 protein_coding processed_transcript 6.781995 4.353954 9.249977 0.5797995 0.1704334 1.085373 0.4474929 0.1522680 0.3981617 0.13534193 0.1582160 1.3307619 0.07022917 0.04053333 0.04266667 0.002133333 7.090406e-01 3.700993e-07 TRUE TRUE
MSTRG.4812.4 ENSG00000108001 HEK293_OSMI2_2hA HEK293_TMG_2hB EBF3 protein_coding   6.781995 4.353954 9.249977 0.5797995 0.1704334 1.085373 0.8385907 0.1566488 1.4819791 0.08883906 0.4232817 3.1623447 0.10463750 0.03253333 0.15906667 0.126533333 6.768324e-02 3.700993e-07 FALSE TRUE
MSTRG.4812.7 ENSG00000108001 HEK293_OSMI2_2hA HEK293_TMG_2hB EBF3 protein_coding   6.781995 4.353954 9.249977 0.5797995 0.1704334 1.085373 0.4718023 0.1934934 0.6972224 0.01451927 0.1039522 1.7971819 0.06241250 0.04510000 0.07563333 0.030533333 3.166754e-01 3.700993e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108001 E001 0.5180316 0.0217681645 3.020789e-02 7.237813e-02 10 129835233 129835282 50 - 0.000 0.361 10.964
ENSG00000108001 E002 210.8440040 0.0065838684 3.900063e-12 8.682201e-11 10 129835283 129836616 1334 - 2.168 2.478 1.033
ENSG00000108001 E003 37.9276880 0.0009852609 9.474201e-04 3.779526e-03 10 129836617 129836698 82 - 1.493 1.701 0.712
ENSG00000108001 E004 53.9566171 0.0045173351 8.634536e-06 5.821720e-05 10 129836699 129836799 101 - 1.609 1.883 0.928
ENSG00000108001 E005 118.6080490 0.0003498087 8.178883e-08 8.449015e-07 10 129836800 129837214 415 - 1.986 2.178 0.642
ENSG00000108001 E006 76.7180678 0.0005217124 3.070072e-01 4.491763e-01 10 129837215 129837396 182 - 1.860 1.922 0.209
ENSG00000108001 E007 47.5742414 0.0075676887 8.463604e-01 9.045095e-01 10 129837397 129837534 138 - 1.670 1.699 0.098
ENSG00000108001 E008 64.2666247 0.0004793953 9.768686e-01 9.895615e-01 10 129837535 129837652 118 - 1.802 1.824 0.076
ENSG00000108001 E009 32.4685698 0.0006592193 8.012083e-01 8.733335e-01 10 129837653 129837654 2 - 1.509 1.546 0.126
ENSG00000108001 E010 90.0005921 0.0004639757 9.502338e-01 9.728493e-01 10 129837655 129837960 306 - 1.950 1.969 0.064
ENSG00000108001 E011 8.9518821 0.0025126271 8.640237e-01 9.163327e-01 10 129839083 129839195 113 - 1.002 1.003 0.004
ENSG00000108001 E012 3.0871940 0.1946386603 7.209726e-01 8.154979e-01 10 129839196 129839300 105 - 0.645 0.553 -0.412
ENSG00000108001 E013 45.1473648 0.0018056356 5.405306e-02 1.163499e-01 10 129840245 129840334 90 - 1.696 1.610 -0.293
ENSG00000108001 E014 16.6461468 0.0014848986 2.197344e-01 3.500653e-01 10 129840335 129840442 108 - 1.189 1.311 0.431
ENSG00000108001 E015 36.0015462 0.0040584406 2.813633e-01 4.212612e-01 10 129840844 129841032 189 - 1.587 1.544 -0.150
ENSG00000108001 E016 61.2515467 0.0119109281 4.821767e-03 1.543458e-02 10 129842116 129842293 178 - 1.852 1.683 -0.572
ENSG00000108001 E017 36.3552132 0.0010615162 2.336766e-02 5.851474e-02 10 129843137 129843202 66 - 1.611 1.495 -0.397
ENSG00000108001 E018 4.2738422 0.0037175155 7.132888e-01 8.098237e-01 10 129846120 129848265 2146 - 0.691 0.760 0.282
ENSG00000108001 E019 40.3137606 0.0016138053 2.182969e-03 7.789440e-03 10 129848392 129848480 89 - 1.670 1.507 -0.554
ENSG00000108001 E020 42.0172501 0.0005863460 2.200589e-04 1.049743e-03 10 129867141 129867267 127 - 1.692 1.502 -0.649
ENSG00000108001 E021 41.0045443 0.0252737516 1.665381e-02 4.417797e-02 10 129867782 129867912 131 - 1.692 1.463 -0.780
ENSG00000108001 E022 7.5287504 0.0022788212 7.531509e-02 1.520241e-01 10 129873452 129873478 27 - 0.992 0.792 -0.761
ENSG00000108001 E023 34.7763530 0.0101043867 3.863737e-02 8.851696e-02 10 129873479 129873596 118 - 1.599 1.446 -0.522
ENSG00000108001 E024 33.9589972 0.0399298467 1.594684e-01 2.744118e-01 10 129877768 129877849 82 - 1.587 1.434 -0.524
ENSG00000108001 E025 39.1020777 0.0070723057 2.860868e-02 6.922603e-02 10 129957258 129957326 69 - 1.644 1.503 -0.481
ENSG00000108001 E026 43.7100000 0.0005269136 4.113455e-03 1.346119e-02 10 129958934 129959007 74 - 1.694 1.557 -0.467
ENSG00000108001 E027 0.0000000       10 129959702 129959784 83 -      
ENSG00000108001 E028 38.4479605 0.0068811608 3.297773e-02 7.776173e-02 10 129962171 129962226 56 - 1.641 1.506 -0.462
ENSG00000108001 E029 44.3127340 0.0035095983 5.075946e-04 2.188491e-03 10 129962942 129963005 64 - 1.721 1.524 -0.671
ENSG00000108001 E030 46.5383674 0.0006373715 1.084078e-03 4.249700e-03 10 129963367 129963523 157 - 1.731 1.577 -0.523
ENSG00000108001 E031 37.9131946 0.0005757552 1.230103e-08 1.492197e-07 10 129963635 129964139 505 - 1.694 1.363 -1.134
ENSG00000108001 E032 10.0264882 0.0017305880 2.168527e-03 7.745492e-03 10 129964140 129964274 135 - 1.145 0.821 -1.205
ENSG00000108001 E033 0.0000000       10 129972898 129973053 156 -