ENSG00000107957

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355946 ENSG00000107957 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3PXD2A protein_coding protein_coding 25.91162 37.32437 19.87453 2.787123 0.9121101 -0.9088579 1.5298081 1.310610 1.796326 0.3912527 0.2342312 0.4518533 0.06267500 0.03723333 0.08983333 0.05260000 8.066571e-02 2.385195e-06 FALSE TRUE
ENST00000369774 ENSG00000107957 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3PXD2A protein_coding protein_coding 25.91162 37.32437 19.87453 2.787123 0.9121101 -0.9088579 7.9731182 11.326303 7.597372 0.9162348 0.1877955 -0.5754802 0.30886667 0.30330000 0.38460000 0.08130000 1.225299e-01 2.385195e-06 FALSE TRUE
ENST00000420222 ENSG00000107957 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3PXD2A protein_coding processed_transcript 25.91162 37.32437 19.87453 2.787123 0.9121101 -0.9088579 1.6181038 1.310113 2.177881 0.4018087 0.4743849 0.7288729 0.07047500 0.03380000 0.10786667 0.07406667 1.783445e-02 2.385195e-06 FALSE TRUE
ENST00000692756 ENSG00000107957 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3PXD2A protein_coding processed_transcript 25.91162 37.32437 19.87453 2.787123 0.9121101 -0.9088579 13.5966722 23.369882 6.719319 1.9291276 0.5632644 -1.7967352 0.49433750 0.62543333 0.34066667 -0.28476667 2.385195e-06 2.385195e-06 FALSE TRUE
MSTRG.4596.7 ENSG00000107957 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3PXD2A protein_coding   25.91162 37.32437 19.87453 2.787123 0.9121101 -0.9088579 0.8673651 0.000000 1.562051 0.0000000 0.7836010 7.2965046 0.04729167 0.00000000 0.07590000 0.07590000 1.253645e-01 2.385195e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107957 E001 1958.517437 0.0024082141 1.655056e-05 1.045986e-04 10 103594027 103599519 5493 - 3.295 3.241 -0.182
ENSG00000107957 E002 145.553089 0.0015786558 2.466187e-13 6.634645e-12 10 103599520 103600291 772 - 2.274 2.042 -0.774
ENSG00000107957 E003 1665.096862 0.0014209801 1.326384e-32 2.704838e-30 10 103600292 103601774 1483 - 3.015 3.248 0.773
ENSG00000107957 E004 1567.434835 0.0012592153 2.930997e-03 1.006075e-02 10 103601775 103603789 2015 - 3.106 3.183 0.253
ENSG00000107957 E005 181.169196 0.0037259743 6.044162e-01 7.249849e-01 10 103605798 103605917 120 - 2.222 2.227 0.019
ENSG00000107957 E006 165.707948 0.0002200602 3.567547e-02 8.295116e-02 10 103611581 103611630 50 - 2.211 2.172 -0.129
ENSG00000107957 E007 334.848356 0.0001899110 4.494687e-04 1.964709e-03 10 103612853 103613168 316 - 2.523 2.473 -0.166
ENSG00000107957 E008 117.272787 0.0002691030 3.572029e-02 8.304415e-02 10 103613169 103613190 22 - 2.071 2.021 -0.167
ENSG00000107957 E009 224.445021 0.0002012188 4.937373e-07 4.370890e-06 10 103617197 103617314 118 - 2.384 2.282 -0.341
ENSG00000107957 E010 175.534134 0.0010642212 2.007661e-04 9.670577e-04 10 103622470 103622553 84 - 2.271 2.179 -0.311
ENSG00000107957 E011 195.547954 0.0024175920 5.136451e-05 2.885781e-04 10 103627089 103627202 114 - 2.332 2.217 -0.386
ENSG00000107957 E012 81.692598 0.0051032687 1.175816e-03 4.559508e-03 10 103660983 103660984 2 - 1.975 1.829 -0.490
ENSG00000107957 E013 142.598594 0.0050904213 1.312851e-04 6.645356e-04 10 103660985 103661114 130 - 2.217 2.069 -0.495
ENSG00000107957 E014 69.511007 0.0177202129 6.695756e-01 7.763625e-01 10 103661637 103661915 279 - 1.812 1.810 -0.007
ENSG00000107957 E015 0.000000       10 103661959 103662035 77 -      
ENSG00000107957 E016 0.000000       10 103668608 103668652 45 -      
ENSG00000107957 E017 0.000000       10 103673438 103673556 119 -      
ENSG00000107957 E018 0.000000       10 103678081 103678164 84 -      
ENSG00000107957 E019 3.777578 0.0062426951 1.869015e-01 3.098366e-01 10 103693028 103693056 29 - 0.767 0.590 -0.747
ENSG00000107957 E020 0.000000       10 103693334 103693478 145 -      
ENSG00000107957 E021 0.000000       10 103693600 103693623 24 -      
ENSG00000107957 E022 5.976434 0.0027930016 1.472796e-02 3.987777e-02 10 103724270 103724361 92 - 0.992 0.707 -1.107
ENSG00000107957 E023 4.805705 0.0032835766 1.307011e-02 3.607361e-02 10 103735732 103735808 77 - 0.929 0.615 -1.260
ENSG00000107957 E024 0.000000       10 103736781 103736866 86 -      
ENSG00000107957 E025 0.000000       10 103762575 103762631 57 -      
ENSG00000107957 E026 5.753965 0.0029729481 6.231237e-01 7.397893e-01 10 103767094 103767169 76 - 0.828 0.782 -0.180
ENSG00000107957 E027 5.492878 0.0038374612 9.785879e-01 9.907416e-01 10 103801282 103801362 81 - 0.767 0.782 0.061
ENSG00000107957 E028 3.545084 0.0476871461 2.712451e-01 4.099676e-01 10 103855195 103855584 390 - 0.733 0.564 -0.727