ENSG00000107949

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278100 ENSG00000107949 HEK293_OSMI2_2hA HEK293_TMG_2hB BCCIP protein_coding protein_coding 120.4307 82.44887 168.1833 4.522925 5.904753 1.028373 61.24477 39.94291 90.10379 2.073811 4.9107466 1.1734473 0.4988333 0.4851000 0.5354000 0.05030000 3.755299e-01 5.430319e-06 FALSE  
ENST00000299130 ENSG00000107949 HEK293_OSMI2_2hA HEK293_TMG_2hB BCCIP protein_coding protein_coding 120.4307 82.44887 168.1833 4.522925 5.904753 1.028373 21.73213 17.23721 23.05941 1.410608 0.9065319 0.4196176 0.1935708 0.2087000 0.1370667 -0.07163333 5.430319e-06 5.430319e-06 FALSE  
ENST00000368759 ENSG00000107949 HEK293_OSMI2_2hA HEK293_TMG_2hB BCCIP protein_coding protein_coding 120.4307 82.44887 168.1833 4.522925 5.904753 1.028373 28.17071 21.82955 38.78353 2.358718 1.9788413 0.8288730 0.2408250 0.2631667 0.2305333 -0.03263333 4.541495e-01 5.430319e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107949 E001 7.769782 4.382681e-03 1.612490e-04 7.974556e-04 10 125823540 125823545 6 + 1.093 0.594 -1.958
ENSG00000107949 E002 468.681967 1.226359e-03 1.274475e-07 1.268629e-06 10 125823546 125823609 64 + 2.716 2.591 -0.416
ENSG00000107949 E003 784.401034 8.941168e-04 1.604734e-05 1.017375e-04 10 125823610 125823722 113 + 2.923 2.843 -0.267
ENSG00000107949 E004 3.438488 6.450677e-03 9.618803e-03 2.782619e-02 10 125825494 125826590 1097 + 0.782 0.353 -2.010
ENSG00000107949 E005 632.404476 1.123999e-04 9.365147e-02 1.808285e-01 10 125826591 125826665 75 + 2.808 2.783 -0.082
ENSG00000107949 E006 747.437245 9.778056e-05 2.916240e-01 4.325014e-01 10 125827558 125827638 81 + 2.875 2.861 -0.048
ENSG00000107949 E007 864.007781 6.322734e-04 7.241890e-01 8.177883e-01 10 125830562 125830651 90 + 2.934 2.927 -0.025
ENSG00000107949 E008 1147.695150 1.174064e-04 4.312096e-02 9.677238e-02 10 125831420 125831607 188 + 3.065 3.042 -0.075
ENSG00000107949 E009 4.072570 6.020333e-03 6.422845e-01 7.551081e-01 10 125831608 125831650 43 + 0.681 0.748 0.278
ENSG00000107949 E010 1207.943864 8.763448e-05 3.282471e-01 4.717379e-01 10 125833772 125833946 175 + 3.082 3.072 -0.034
ENSG00000107949 E011 645.228211 3.616001e-03 5.685398e-01 6.951918e-01 10 125836104 125836551 448 + 2.813 2.797 -0.054
ENSG00000107949 E012 238.605884 1.666407e-03 7.906682e-02 1.580194e-01 10 125841255 125841260 6 + 2.350 2.401 0.172
ENSG00000107949 E013 423.238360 1.289534e-04 8.542874e-04 3.453002e-03 10 125841261 125841330 70 + 2.597 2.656 0.196
ENSG00000107949 E014 764.992719 4.478899e-04 8.461959e-29 1.283501e-26 10 125841331 125842805 1475 + 2.797 2.970 0.576
ENSG00000107949 E015 5.200322 3.384125e-03 2.958653e-01 4.370091e-01 10 125852537 125852634 98 + 0.724 0.862 0.547
ENSG00000107949 E016 411.358622 3.642400e-03 7.609548e-02 1.532645e-01 10 125853125 125853695 571 + 2.582 2.647 0.216