ENSG00000107938

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337623 ENSG00000107938 HEK293_OSMI2_2hA HEK293_TMG_2hB EDRF1 protein_coding protein_coding 21.21214 9.949155 31.02882 0.5748735 0.2929228 1.639978 2.040810 0.2370002 4.311464 0.23700020 0.95971156 4.1289361 0.0810250 0.02670000 0.13850000 0.1118000 0.112222445 0.001326811 FALSE TRUE
ENST00000356792 ENSG00000107938 HEK293_OSMI2_2hA HEK293_TMG_2hB EDRF1 protein_coding protein_coding 21.21214 9.949155 31.02882 0.5748735 0.2929228 1.639978 8.568926 2.3178854 14.034417 0.19036728 1.14517154 2.5929048 0.3368125 0.23553333 0.45256667 0.2170333 0.002987902 0.001326811 FALSE TRUE
ENST00000368812 ENSG00000107938 HEK293_OSMI2_2hA HEK293_TMG_2hB EDRF1 protein_coding retained_intron 21.21214 9.949155 31.02882 0.5748735 0.2929228 1.639978 3.286112 4.9803096 1.350298 0.94287894 0.77499342 -1.8752063 0.2364833 0.49266667 0.04396667 -0.4487000 0.057996140 0.001326811 FALSE TRUE
ENST00000368813 ENSG00000107938 HEK293_OSMI2_2hA HEK293_TMG_2hB EDRF1 protein_coding protein_coding 21.21214 9.949155 31.02882 0.5748735 0.2929228 1.639978 1.276620 0.8334920 1.539393 0.12280886 0.29610503 0.8772571 0.0663000 0.08503333 0.04953333 -0.0355000 0.293474948 0.001326811 FALSE TRUE
ENST00000525091 ENSG00000107938 HEK293_OSMI2_2hA HEK293_TMG_2hB EDRF1 protein_coding retained_intron 21.21214 9.949155 31.02882 0.5748735 0.2929228 1.639978 1.528369 0.5804953 2.475395 0.05665363 0.09475883 2.0734777 0.0700000 0.05826667 0.07986667 0.0216000 0.310794878 0.001326811 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107938 E001 0.1482932 0.0413094988 8.837536e-02   10 125719515 125719575 61 + 0.000 0.238 13.119
ENSG00000107938 E002 0.4481018 0.0951269502 7.444158e-02 1.506429e-01 10 125719576 125719665 90 + 0.059 0.389 3.325
ENSG00000107938 E003 0.4438354 0.0959237436 7.454461e-02 1.508107e-01 10 125719666 125719697 32 + 0.059 0.389 3.326
ENSG00000107938 E004 0.8921407 0.0132609071 2.694110e-01 4.079213e-01 10 125719698 125719701 4 + 0.271 0.000 -11.362
ENSG00000107938 E005 1.0404339 0.0118726426 8.147188e-01 8.826221e-01 10 125719702 125719702 1 + 0.271 0.239 -0.245
ENSG00000107938 E006 1.3307793 0.0109983852 5.864250e-01 7.099887e-01 10 125719703 125719708 6 + 0.334 0.239 -0.660
ENSG00000107938 E007 45.4885361 0.0007953261 7.262981e-04 2.993473e-03 10 125719709 125719883 175 + 1.599 1.388 -0.724
ENSG00000107938 E008 37.4945022 0.0409665120 7.483872e-02 1.512688e-01 10 125719884 125719915 32 + 1.512 1.339 -0.600
ENSG00000107938 E009 58.1961398 0.0005771073 2.329220e-04 1.103739e-03 10 125721204 125721282 79 + 1.703 1.502 -0.684
ENSG00000107938 E010 90.8553269 0.0003060640 2.456586e-08 2.813912e-07 10 125721283 125721412 130 + 1.900 1.638 -0.883
ENSG00000107938 E011 62.6045142 0.0024395468 3.641159e-06 2.675640e-05 10 125723068 125723134 67 + 1.743 1.460 -0.965
ENSG00000107938 E012 85.0139912 0.0003267846 1.348861e-08 1.622874e-07 10 125723811 125723936 126 + 1.873 1.592 -0.950
ENSG00000107938 E013 83.2920675 0.0003583947 8.189889e-09 1.026022e-07 10 125725318 125725442 125 + 1.866 1.576 -0.983
ENSG00000107938 E014 67.3055686 0.0003589005 3.539099e-07 3.225127e-06 10 125725682 125725765 84 + 1.774 1.492 -0.959
ENSG00000107938 E015 62.7282565 0.0006495976 5.939270e-05 3.284325e-04 10 125725766 125725838 73 + 1.737 1.522 -0.734
ENSG00000107938 E016 56.8160942 0.0057506520 5.939114e-04 2.511321e-03 10 125729003 125729104 102 + 1.696 1.471 -0.767
ENSG00000107938 E017 89.8644823 0.0010215794 2.221179e-08 2.567306e-07 10 125729358 125729479 122 + 1.899 1.623 -0.931
ENSG00000107938 E018 0.2966881 0.0290785164 1.000000e+00   10 125730272 125730287 16 + 0.110 0.000 -9.777
ENSG00000107938 E019 83.9937147 0.0003428540 5.667682e-05 3.149913e-04 10 125730288 125730399 112 + 1.856 1.680 -0.596
ENSG00000107938 E020 2.5948364 0.0069081275 1.505917e-01 2.624818e-01 10 125731865 125731925 61 + 0.520 0.239 -1.658
ENSG00000107938 E021 100.4684325 0.0004002416 5.841424e-06 4.095634e-05 10 125733404 125733551 148 + 1.933 1.748 -0.625
ENSG00000107938 E022 106.1629139 0.0012461510 6.392189e-06 4.442500e-05 10 125733635 125733743 109 + 1.959 1.770 -0.636
ENSG00000107938 E023 99.8740136 0.0002959200 1.392335e-02 3.805231e-02 10 125734072 125734183 112 + 1.915 1.840 -0.254
ENSG00000107938 E024 135.1045179 0.0002459751 7.347654e-03 2.212178e-02 10 125735644 125735886 243 + 2.044 1.977 -0.227
ENSG00000107938 E025 50.8418905 0.0004455813 5.326869e-03 1.682140e-02 10 125735887 125735904 18 + 1.640 1.492 -0.506
ENSG00000107938 E026 46.1759788 0.0004908695 7.188662e-03 2.171523e-02 10 125737918 125737922 5 + 1.599 1.449 -0.516
ENSG00000107938 E027 67.3799684 0.0003678278 7.128731e-03 2.155928e-02 10 125737923 125737989 67 + 1.754 1.638 -0.393
ENSG00000107938 E028 101.6815009 0.0002976599 4.975104e-03 1.586091e-02 10 125738295 125738445 151 + 1.926 1.835 -0.308
ENSG00000107938 E029 132.4273191 0.0070726589 1.161624e-01 2.144999e-01 10 125740463 125740651 189 + 2.032 1.984 -0.162
ENSG00000107938 E030 141.8454752 0.0002495082 3.210690e-01 4.642712e-01 10 125741001 125741201 201 + 2.052 2.053 0.006
ENSG00000107938 E031 13.0406385 0.0013109550 1.394773e-02 3.810284e-02 10 125741202 125741665 464 + 0.979 1.269 1.043
ENSG00000107938 E032 10.8800972 0.0016368740 6.304305e-02 1.317781e-01 10 125742220 125742345 126 + 1.011 0.787 -0.851
ENSG00000107938 E033 132.3067226 0.0002629515 6.192644e-02 1.298611e-01 10 125743058 125743276 219 + 2.028 1.993 -0.117
ENSG00000107938 E034 65.0488620 0.0005728870 6.289602e-01 7.444232e-01 10 125745707 125745771 65 + 1.713 1.725 0.040
ENSG00000107938 E035 106.5268935 0.0003626063 2.942147e-01 4.353110e-01 10 125745772 125745930 159 + 1.910 1.993 0.281
ENSG00000107938 E036 12.0048599 0.0014032084 2.249373e-02 5.670862e-02 10 125746701 125747535 835 + 1.063 0.787 -1.041
ENSG00000107938 E037 120.0226246 0.0003108223 3.615594e-02 8.389068e-02 10 125747536 125747694 159 + 1.952 2.073 0.406
ENSG00000107938 E038 102.1474791 0.0003219107 2.027811e-02 5.207008e-02 10 125747863 125747952 90 + 1.879 2.015 0.460
ENSG00000107938 E039 89.2241627 0.0003439352 7.424240e-02 1.503185e-01 10 125747953 125748012 60 + 1.826 1.945 0.404
ENSG00000107938 E040 51.3757936 0.0004496611 1.618190e-05 1.025048e-04 10 125748013 125749096 1084 + 1.547 1.826 0.944
ENSG00000107938 E041 6.9502616 0.0024439157 2.612323e-02 6.419227e-02 10 125749273 125749296 24 + 0.727 1.051 1.241
ENSG00000107938 E042 9.9330549 0.0017768699 3.406345e-03 1.145630e-02 10 125749297 125749411 115 + 0.850 1.214 1.341
ENSG00000107938 E043 121.7966806 0.0002612569 1.156164e-06 9.473285e-06 10 125749412 125749565 154 + 1.934 2.154 0.737
ENSG00000107938 E044 0.5244761 0.2583563223 5.026350e-01 6.386856e-01 10 125749566 125749813 248 + 0.111 0.242 1.361
ENSG00000107938 E045 85.8217704 0.0003302719 5.465458e-05 3.049912e-04 10 125752799 125752914 116 + 1.785 2.003 0.732
ENSG00000107938 E046 71.3691282 0.0008159509 6.891875e-03 2.094326e-02 10 125753694 125753778 85 + 1.721 1.895 0.589
ENSG00000107938 E047 75.9199021 0.0003469536 1.601809e-02 4.277490e-02 10 125753779 125753845 67 + 1.749 1.904 0.523
ENSG00000107938 E048 1.6940743 0.0087970030 4.422332e-01 5.838879e-01 10 125761228 125761314 87 + 0.334 0.505 0.926
ENSG00000107938 E049 163.1884845 0.0016491083 1.988381e-08 2.319394e-07 10 125763301 125763524 224 + 2.054 2.297 0.812
ENSG00000107938 E050 312.7925995 0.0121075787 1.526194e-09 2.186922e-08 10 125763525 125764040 516 + 2.295 2.663 1.224
ENSG00000107938 E051 47.6812501 0.0195491184 4.543473e-13 1.178783e-11 10 125764041 125764143 103 + 1.364 2.022 2.236