ENSG00000107929

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316157 ENSG00000107929 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4B protein_coding protein_coding 26.79143 24.19401 32.59609 0.565951 0.9643593 0.4298956 12.8078982 11.170018 15.5661428 1.5398502 0.62992713 0.4784155 0.47912083 0.4600333 0.4792667 0.01923333 9.331699e-01 7.749012e-30 FALSE TRUE
ENST00000448368 ENSG00000107929 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4B protein_coding protein_coding 26.79143 24.19401 32.59609 0.565951 0.9643593 0.4298956 0.6314475 1.771687 0.0000000 0.1146644 0.00000000 -7.4771000 0.02607917 0.0732000 0.0000000 -0.07320000 7.749012e-30 7.749012e-30 FALSE FALSE
ENST00000690211 ENSG00000107929 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4B protein_coding protein_coding 26.79143 24.19401 32.59609 0.565951 0.9643593 0.4298956 4.9292111 3.908754 6.8348723 0.6398056 1.00222348 0.8046285 0.18260833 0.1615333 0.2082000 0.04666667 6.020662e-01 7.749012e-30 FALSE FALSE
ENST00000690516 ENSG00000107929 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4B protein_coding nonsense_mediated_decay 26.79143 24.19401 32.59609 0.565951 0.9643593 0.4298956 2.6052355 5.881697 0.1943925 1.8176191 0.09744939 -4.8492695 0.10618750 0.2444000 0.0058000 -0.23860000 2.231142e-04 7.749012e-30 FALSE TRUE
MSTRG.3471.11 ENSG00000107929 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4B protein_coding   26.79143 24.19401 32.59609 0.565951 0.9643593 0.4298956 2.9549134 0.000000 5.5761026 0.0000000 0.60853033 9.1256983 0.09835000 0.0000000 0.1720667 0.17206667 2.097894e-26 7.749012e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107929 E001 2.8407781 0.0154777089 9.545659e-02 1.835641e-01 10 806933 806951 19 - 0.422 0.750 1.493
ENSG00000107929 E002 28.0395464 0.0007089242 1.545592e-01 2.678324e-01 10 806952 807879 928 - 1.380 1.549 0.584
ENSG00000107929 E003 14.4299479 0.0368911038 8.330405e-01 8.953834e-01 10 807880 808272 393 - 1.159 1.209 0.179
ENSG00000107929 E004 1.7325925 0.0547108470 1.105213e-01 2.062911e-01 10 809497 809548 52 - 0.260 0.608 1.898
ENSG00000107929 E005 1023.6872487 0.0110778333 1.852672e-10 3.121237e-09 10 809549 811805 2257 - 2.801 3.170 1.225
ENSG00000107929 E006 28.4807973 0.0097388758 4.037571e-14 1.213995e-12 10 811806 811821 16 - 0.989 1.728 2.585
ENSG00000107929 E007 626.2969838 0.0049490505 3.659545e-09 4.884043e-08 10 811822 812505 684 - 2.645 2.926 0.935
ENSG00000107929 E008 401.0080330 0.0003796640 2.453498e-10 4.046382e-09 10 812506 812920 415 - 2.500 2.701 0.669
ENSG00000107929 E009 304.5742646 0.0030515082 7.191150e-01 8.140423e-01 10 812921 813213 293 - 2.440 2.529 0.296
ENSG00000107929 E010 7.3114527 0.0024028535 2.794365e-01 4.191913e-01 10 813214 813256 43 - 0.938 0.880 -0.218
ENSG00000107929 E011 2.5913961 0.0127391606 8.635680e-01 9.160053e-01 10 814018 814441 424 - 0.539 0.569 0.138
ENSG00000107929 E012 2.3669296 0.0370304264 8.425564e-01 9.019003e-01 10 814442 814636 195 - 0.504 0.523 0.094
ENSG00000107929 E013 22.1774812 0.0010107977 6.837458e-04 2.839528e-03 10 814637 814741 105 - 1.183 1.510 1.140
ENSG00000107929 E014 207.2962247 0.0048897947 3.835559e-01 5.277671e-01 10 814742 814850 109 - 2.298 2.338 0.135
ENSG00000107929 E015 222.8834532 0.0002301847 4.998775e-04 2.159642e-03 10 814946 815070 125 - 2.351 2.346 -0.016
ENSG00000107929 E016 3.6768799 0.1149880480 9.799265e-01 9.914746e-01 10 815071 815715 645 - 0.633 0.692 0.250
ENSG00000107929 E017 277.2505910 0.0006590434 1.243634e-03 4.788964e-03 10 817725 817889 165 - 2.443 2.445 0.006
ENSG00000107929 E018 23.0956238 0.0207853192 1.729009e-02 4.558501e-02 10 817890 820799 2910 - 1.449 1.289 -0.554
ENSG00000107929 E019 154.0795874 0.0002832672 6.987854e-01 7.986703e-01 10 820800 820845 46 - 2.156 2.224 0.227
ENSG00000107929 E020 1.4068483 0.0901597816 3.094328e-01 4.517239e-01 10 820846 820930 85 - 0.260 0.516 1.476
ENSG00000107929 E021 293.4837040 0.0009402117 5.935860e-03 1.843977e-02 10 825065 825316 252 - 2.462 2.472 0.034
ENSG00000107929 E022 158.1925897 0.0048438416 4.756626e-02 1.048482e-01 10 825764 825870 107 - 2.204 2.196 -0.027
ENSG00000107929 E023 0.2987644 0.0272902425 2.502596e-01   10 825871 827283 1413 - 0.190 0.000 -10.740
ENSG00000107929 E024 211.0706386 0.0076783314 2.004132e-01 3.267301e-01 10 829385 829594 210 - 2.317 2.333 0.055
ENSG00000107929 E025 106.0776984 0.0095538989 5.050299e-01 6.408589e-01 10 829681 829734 54 - 2.010 2.046 0.123
ENSG00000107929 E026 162.0996083 0.0146494330 3.159524e-02 7.506426e-02 10 830867 830977 111 - 2.236 2.179 -0.193
ENSG00000107929 E027 151.5486557 0.0072367455 6.476634e-05 3.547310e-04 10 836403 836506 104 - 2.233 2.110 -0.412
ENSG00000107929 E028 191.8251393 0.0101109736 1.045485e-05 6.920234e-05 10 842932 843068 137 - 2.351 2.188 -0.545
ENSG00000107929 E029 147.6774095 0.0025847243 4.309609e-10 6.829298e-09 10 844977 845055 79 - 2.237 2.076 -0.539
ENSG00000107929 E030 107.4931252 0.0002707074 1.835292e-12 4.307900e-11 10 863743 863778 36 - 2.104 1.937 -0.560
ENSG00000107929 E031 147.9745098 0.0003001089 1.404316e-19 8.546209e-18 10 863779 863883 105 - 2.251 2.056 -0.654
ENSG00000107929 E032 89.9877143 0.0004754377 4.151319e-10 6.600224e-09 10 864123 864153 31 - 2.024 1.861 -0.549
ENSG00000107929 E033 116.0715170 0.0032033695 2.445500e-08 2.802400e-07 10 864154 864240 87 - 2.133 1.970 -0.546
ENSG00000107929 E034 82.2738067 0.0003031517 1.750536e-11 3.500831e-10 10 864241 864269 29 - 1.997 1.807 -0.638
ENSG00000107929 E035 63.6437986 0.0003733332 1.124789e-12 2.735402e-11 10 864270 864270 1 - 1.908 1.662 -0.831
ENSG00000107929 E036 0.3332198 0.0296960582 9.048869e-01   10 870009 870012 4 - 0.105 0.142 0.501
ENSG00000107929 E037 5.9579757 0.0161147489 6.814093e-02 1.402827e-01 10 870013 870083 71 - 0.909 0.722 -0.736
ENSG00000107929 E038 0.0000000       10 870084 873205 3122 -      
ENSG00000107929 E039 91.7468541 0.0003632613 1.140536e-15 4.273560e-14 10 884447 884506 60 - 2.058 1.830 -0.767
ENSG00000107929 E040 103.5670955 0.0003018636 7.611207e-26 8.995136e-24 10 885641 885760 120 - 2.134 1.827 -1.030
ENSG00000107929 E041 0.1472490 0.0435170128 5.707721e-01   10 889442 889834 393 - 0.105 0.000 -9.740
ENSG00000107929 E042 0.0000000       10 903208 903343 136 -      
ENSG00000107929 E043 0.2987644 0.0272902425 2.502596e-01   10 903430 903515 86 - 0.190 0.000 -10.740
ENSG00000107929 E044 0.2903454 0.3438788720 3.426735e-01   10 924383 924433 51 - 0.189 0.000 -10.735
ENSG00000107929 E045 64.6021080 0.0206767375 3.232660e-08 3.616925e-07 10 931428 931705 278 - 1.954 1.559 -1.335
ENSG00000107929 E046 5.9398699 0.0376461285 7.678411e-04 3.142611e-03 10 931779 931834 56 - 1.001 0.521 -1.959