ENSG00000107897

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375888 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding protein_coding 5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 1.06986466 0.00000000 1.3713555 0.00000000 0.575310024 7.1099408 0.131100000 0.00000000 0.17390000 0.1739000000 0.004106915 0.004106915 FALSE TRUE
ENST00000375897 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding protein_coding 5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 0.30219265 0.08526933 0.1799964 0.08526933 0.179996375 0.9958881 0.054900000 0.06346667 0.02240000 -0.0410666667 0.787204037 0.004106915 FALSE TRUE
ENST00000396271 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding protein_coding 5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 1.73023090 0.50390394 2.9214859 0.09834241 0.231308078 2.5120615 0.315158333 0.37686667 0.37663333 -0.0002333333 1.000000000 0.004106915 FALSE TRUE
ENST00000676648 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding nonsense_mediated_decay 5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 0.04053196 0.18588591 0.0000000 0.09303967 0.000000000 -4.2919417 0.026837500 0.13730000 0.00000000 -0.1373000000 0.010237370 0.004106915 TRUE TRUE
ENST00000676732 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding protein_coding 5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 0.16096133 0.14912648 0.2265505 0.14912648 0.144174212 0.5719744 0.042737500 0.11530000 0.03033333 -0.0849666667 1.000000000 0.004106915 FALSE TRUE
ENST00000676997 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding protein_coding 5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 0.22768820 0.14751041 0.1884349 0.03664145 0.006494433 0.3332184 0.081500000 0.11140000 0.02443333 -0.0869666667 0.007678901 0.004106915 FALSE TRUE
ENST00000677311 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding protein_coding 5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 0.06875497 0.00000000 0.5340744 0.00000000 0.271275339 5.7657321 0.009745833 0.00000000 0.07026667 0.0702666667 0.492274062 0.004106915 FALSE TRUE
ENST00000677509 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding protein_coding 5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 0.20696333 0.00000000 0.2574500 0.00000000 0.193651092 4.7411973 0.061545833 0.00000000 0.03453333 0.0345333333 0.683398978 0.004106915 FALSE TRUE
ENST00000677667 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding protein_coding 5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 0.13603231 0.06494628 0.0000000 0.06494628 0.000000000 -2.9058568 0.024870833 0.05020000 0.00000000 -0.0502000000 0.430717034 0.004106915 FALSE TRUE
MSTRG.3692.24 ENSG00000107897 HEK293_OSMI2_2hA HEK293_TMG_2hB ACBD5 protein_coding   5.138342 1.333497 7.735138 0.02073307 0.2044519 2.527298 0.51189312 0.05255894 1.3528768 0.05255894 0.255739815 4.4452953 0.062825000 0.03856667 0.17663333 0.1380666667 0.152038517 0.004106915 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107897 E001 0.0000000       10 27168135 27170270 2136 -      
ENSG00000107897 E002 0.8168978 0.0151265404 0.892324196 0.935212864 10 27181682 27182715 1034 - 0.192 0.246 0.450
ENSG00000107897 E003 1.7296624 0.0083616182 0.431403708 0.573952185 10 27182838 27184315 1478 - 0.325 0.516 1.034
ENSG00000107897 E004 0.0000000       10 27195214 27195214 1 -      
ENSG00000107897 E005 0.0000000       10 27195215 27195216 2 -      
ENSG00000107897 E006 0.3299976 0.0276542001 0.014890638   10 27195217 27195219 3 - 0.000 0.401 14.445
ENSG00000107897 E007 0.4751703 0.0220247344 0.061079661 0.128452190 10 27195220 27195229 10 - 0.057 0.401 3.447
ENSG00000107897 E008 12.2502517 0.1722529640 0.039894755 0.090837369 10 27195230 27195387 158 - 0.844 1.433 2.124
ENSG00000107897 E009 47.7205928 0.0541561614 0.000278933 0.001294030 10 27195388 27195991 604 - 1.432 1.944 1.737
ENSG00000107897 E010 121.8214800 0.0085554262 0.151000762 0.263022971 10 27195992 27197352 1361 - 1.949 2.091 0.477
ENSG00000107897 E011 19.6432162 0.0422600931 0.699499555 0.799202066 10 27197353 27197442 90 - 1.179 1.292 0.399
ENSG00000107897 E012 0.1451727 0.0423390769 1.000000000   10 27198984 27199101 118 - 0.057 0.000 -9.066
ENSG00000107897 E013 0.9233738 0.0145338297 0.359220409 0.503549723 10 27201958 27202464 507 - 0.192 0.401 1.447
ENSG00000107897 E014 13.9058666 0.0016833776 0.422072755 0.565238479 10 27204440 27204446 7 - 1.069 1.037 -0.117
ENSG00000107897 E015 26.4142809 0.0064968965 0.973352758 0.987351535 10 27204447 27204549 103 - 1.312 1.378 0.230
ENSG00000107897 E016 22.8717675 0.0078144413 0.290114781 0.430904005 10 27205198 27205248 51 - 1.231 1.392 0.562
ENSG00000107897 E017 39.2895812 0.0005664304 0.407089178 0.550700614 10 27208246 27208445 200 - 1.491 1.497 0.023
ENSG00000107897 E018 37.0436018 0.0006363068 0.022603129 0.056926100 10 27210814 27210921 108 - 1.487 1.377 -0.379
ENSG00000107897 E019 37.9006483 0.0005470936 0.007599402 0.022769584 10 27210922 27211081 160 - 1.502 1.363 -0.481
ENSG00000107897 E020 35.1092225 0.0015614158 0.004207138 0.013723199 10 27215535 27215641 107 - 1.473 1.301 -0.594
ENSG00000107897 E021 19.5694427 0.0092560839 0.048390318 0.106310889 10 27217980 27217982 3 - 1.231 1.067 -0.588
ENSG00000107897 E022 42.7699873 0.0022745281 0.001242131 0.004783859 10 27217983 27218183 201 - 1.559 1.377 -0.627
ENSG00000107897 E023 28.1516009 0.0007392722 0.051676382 0.112141300 10 27219723 27219803 81 - 1.372 1.267 -0.368
ENSG00000107897 E024 22.7116251 0.0017774674 0.181622190 0.303273208 10 27219804 27219857 54 - 1.275 1.210 -0.228
ENSG00000107897 E025 0.2966881 0.0294274196 1.000000000   10 27220373 27220464 92 - 0.107 0.000 -10.048
ENSG00000107897 E026 0.0000000       10 27221696 27221746 51 -      
ENSG00000107897 E027 4.5457166 0.0045821429 0.961507910 0.979753490 10 27223207 27223239 33 - 0.638 0.682 0.186
ENSG00000107897 E028 24.7589544 0.0020376389 0.120749323 0.221030939 10 27223338 27223452 115 - 1.312 1.230 -0.287
ENSG00000107897 E029 0.0000000       10 27230231 27231747 1517 -      
ENSG00000107897 E030 18.9666816 0.0107610976 0.751949573 0.838294955 10 27231748 27231820 73 - 1.186 1.211 0.091
ENSG00000107897 E031 0.1472490 0.0425680902 1.000000000   10 27234358 27234488 131 - 0.057 0.000 -9.066
ENSG00000107897 E032 28.1084833 0.0009684506 0.137940541 0.245211041 10 27235092 27235212 121 - 1.364 1.301 -0.220
ENSG00000107897 E033 26.8279069 0.0008816408 0.141336144 0.249866634 10 27240319 27240474 156 - 1.349 1.284 -0.224
ENSG00000107897 E034 10.2170387 0.0090744672 0.812543993 0.881108279 10 27240475 27240484 10 - 0.944 0.971 0.100
ENSG00000107897 E035 6.0934868 0.0043959835 0.700642079 0.800068353 10 27240485 27240673 189 - 0.737 0.850 0.448
ENSG00000107897 E036 7.7587335 0.0021822002 0.453955940 0.594661847 10 27240674 27240879 206 - 0.853 0.801 -0.204
ENSG00000107897 E037 1.3318114 0.0096337080 0.125777839 0.228252910 10 27241827 27242058 232 - 0.353 0.000 -12.158
ENSG00000107897 E038 2.5704090 0.0078403251 0.511017045 0.646132283 10 27242059 27242389 331 - 0.490 0.402 -0.458
ENSG00000107897 E039 0.6537541 0.4258371446 0.239228161 0.373218627 10 27242897 27243046 150 - 0.106 0.404 2.466