ENSG00000107863

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376410 ENSG00000107863 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP21 protein_coding protein_coding 12.44423 6.362048 16.74188 0.6450521 0.6620091 1.394494 6.7519647 1.42078127 10.116435 0.46262019 0.06926714 2.823251 0.4712000 0.2147667 0.6062 0.3914333 8.572438e-05 6.722373e-17 FALSE TRUE
ENST00000638156 ENSG00000107863 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP21 protein_coding nonsense_mediated_decay 12.44423 6.362048 16.74188 0.6450521 0.6620091 1.394494 2.1898411 3.61656997 1.385809 0.29897992 0.05787341 -1.377504 0.2730375 0.5768667 0.0831 -0.4937667 6.722373e-17 6.722373e-17 FALSE TRUE
ENST00000680286 ENSG00000107863 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP21 protein_coding protein_coding 12.44423 6.362048 16.74188 0.6450521 0.6620091 1.394494 0.1975934 0.69326691 0.000000 0.13487475 0.00000000 -6.136000 0.0277125 0.1097000 0.0000 -0.1097000 9.244637e-16 6.722373e-17 FALSE TRUE
MSTRG.3670.13 ENSG00000107863 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP21 protein_coding   12.44423 6.362048 16.74188 0.6450521 0.6620091 1.394494 0.8157399 0.05237008 1.051490 0.02651894 0.72593540 4.089093 0.0454000 0.0075000 0.0598 0.0523000 7.132740e-01 6.722373e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107863 E001 0.1482932 0.0439594971 1.503435e-01   10 24583609 24583613 5 - 0.000 0.208 14.574
ENSG00000107863 E002 2.0532155 0.0735202051 4.503799e-02 1.002716e-01 10 24583614 24583616 3 - 0.308 0.721 2.045
ENSG00000107863 E003 4.7772242 0.0033401932 1.967112e-03 7.123318e-03 10 24583617 24583630 14 - 0.533 1.009 1.933
ENSG00000107863 E004 580.2521951 0.0112563336 1.636531e-10 2.784586e-09 10 24583631 24585701 2071 - 2.587 2.932 1.147
ENSG00000107863 E005 64.1589855 0.0004603290 1.534268e-01 2.663329e-01 10 24585702 24585716 15 - 1.715 1.848 0.449
ENSG00000107863 E006 117.6154806 0.0002943432 4.843868e-04 2.100381e-03 10 24585717 24585919 203 - 1.957 2.144 0.627
ENSG00000107863 E007 31.5420729 0.0007220059 1.273388e-01 2.304339e-01 10 24585920 24585929 10 - 1.406 1.571 0.565
ENSG00000107863 E008 67.2872835 0.0004240916 4.922189e-03 1.571284e-02 10 24585930 24586032 103 - 1.713 1.908 0.656
ENSG00000107863 E009 56.3697077 0.0009266722 5.177361e-02 1.123163e-01 10 24586033 24586106 74 - 1.648 1.812 0.557
ENSG00000107863 E010 42.8371193 0.0022877530 1.667614e-01 2.839720e-01 10 24589271 24589302 32 - 1.542 1.689 0.503
ENSG00000107863 E011 4.1394465 0.0061186154 2.143009e-02 5.449557e-02 10 24589303 24590042 740 - 0.725 0.348 -1.810
ENSG00000107863 E012 2.3712011 0.0061401525 5.229324e-03 1.655575e-02 10 24590206 24590453 248 - 0.575 0.000 -15.245
ENSG00000107863 E013 2.0639039 0.0069515682 9.727717e-03 2.809193e-02 10 24590454 24590479 26 - 0.533 0.000 -15.052
ENSG00000107863 E014 2.0639039 0.0069515682 9.727717e-03 2.809193e-02 10 24590480 24590550 71 - 0.533 0.000 -15.052
ENSG00000107863 E015 72.1536699 0.0021564858 9.322972e-02 1.801703e-01 10 24591225 24591330 106 - 1.761 1.908 0.494
ENSG00000107863 E016 2.8244997 0.0710534567 4.116298e-01 5.551706e-01 10 24591345 24591641 297 - 0.576 0.450 -0.602
ENSG00000107863 E017 48.6528817 0.0004985125 3.141414e-01 4.568271e-01 10 24591642 24591683 42 - 1.602 1.721 0.405
ENSG00000107863 E018 73.6963877 0.0057273000 5.251460e-01 6.585643e-01 10 24591887 24592012 126 - 1.783 1.889 0.357
ENSG00000107863 E019 28.8608513 0.0146851768 3.487310e-01 4.929640e-01 10 24594950 24594969 20 - 1.373 1.526 0.527
ENSG00000107863 E020 41.3813197 0.0006163334 6.658825e-01 7.734627e-01 10 24594970 24595000 31 - 1.542 1.631 0.306
ENSG00000107863 E021 47.3590060 0.0005905541 8.457507e-01 9.040611e-01 10 24595001 24595039 39 - 1.604 1.678 0.254
ENSG00000107863 E022 60.9476261 0.0008430248 7.255309e-01 8.187678e-01 10 24595117 24595190 74 - 1.705 1.787 0.279
ENSG00000107863 E023 62.4444314 0.0066781431 8.536763e-01 9.094631e-01 10 24595717 24595795 79 - 1.717 1.795 0.265
ENSG00000107863 E024 71.3702276 0.0009611928 7.457903e-01 8.337331e-01 10 24595888 24596043 156 - 1.780 1.829 0.164
ENSG00000107863 E025 6.6254290 0.0238939747 4.591577e-03 1.479531e-02 10 24596044 24596739 696 - 0.907 0.454 -1.940
ENSG00000107863 E026 51.8722071 0.0010219849 3.599005e-01 5.042121e-01 10 24596740 24596821 82 - 1.656 1.667 0.038
ENSG00000107863 E027 38.6112298 0.0007028456 2.265312e-01 3.582664e-01 10 24596822 24596840 19 - 1.542 1.526 -0.054
ENSG00000107863 E028 47.4761677 0.0005270511 4.473092e-01 5.887108e-01 10 24596841 24596882 42 - 1.618 1.637 0.065
ENSG00000107863 E029 39.8601032 0.0005425510 8.078282e-01 8.778940e-01 10 24597447 24597468 22 - 1.537 1.585 0.164
ENSG00000107863 E030 67.6911338 0.0004023793 4.713737e-01 6.104941e-01 10 24597469 24597583 115 - 1.767 1.796 0.098
ENSG00000107863 E031 49.9803231 0.0004866874 9.668407e-02 1.854010e-01 10 24597945 24598009 65 - 1.651 1.619 -0.111
ENSG00000107863 E032 51.9231977 0.0043802164 1.498406e-02 4.045208e-02 10 24600646 24600788 143 - 1.682 1.587 -0.324
ENSG00000107863 E033 48.6756461 0.0004491328 1.791955e-01 3.001357e-01 10 24600789 24600930 142 - 1.639 1.625 -0.049
ENSG00000107863 E034 58.4168392 0.0003980001 5.751090e-04 2.440969e-03 10 24601978 24602103 126 - 1.740 1.612 -0.434
ENSG00000107863 E035 36.4755903 0.0005650954 1.515057e-03 5.684862e-03 10 24604312 24604348 37 - 1.548 1.386 -0.556
ENSG00000107863 E036 0.0000000       10 24605767 24605774 8 -      
ENSG00000107863 E037 0.2934659 0.0314339832 4.126605e-01   10 24607444 24607498 55 - 0.069 0.208 1.830
ENSG00000107863 E038 66.2761692 0.0004517935 7.405838e-05 3.995938e-04 10 24607499 24607601 103 - 1.796 1.650 -0.496
ENSG00000107863 E039 74.5746522 0.0003390081 6.721479e-04 2.796635e-03 10 24607745 24607903 159 - 1.838 1.736 -0.346
ENSG00000107863 E040 1.7746132 0.0078925462 3.911159e-01 5.350644e-01 10 24609430 24609453 24 - 0.344 0.539 1.026
ENSG00000107863 E041 63.3097006 0.0004160755 9.020452e-03 2.632962e-02 10 24619473 24619681 209 - 1.763 1.690 -0.247
ENSG00000107863 E042 100.7917662 0.0005283044 2.211524e-06 1.704017e-05 10 24619682 24620149 468 - 1.978 1.836 -0.475
ENSG00000107863 E043 71.5233647 0.0029621776 5.015992e-05 2.826296e-04 10 24620150 24620439 290 - 1.836 1.668 -0.568
ENSG00000107863 E044 74.5944103 0.0003836727 1.606067e-06 1.275475e-05 10 24620440 24620878 439 - 1.857 1.678 -0.602
ENSG00000107863 E045 95.3718195 0.0005789542 3.281960e-10 5.305550e-09 10 24620879 24621369 491 - 1.969 1.741 -0.768
ENSG00000107863 E046 0.0000000       10 24622733 24622762 30 -      
ENSG00000107863 E047 0.3686942 0.0304794270 4.129660e-01 5.565170e-01 10 24622763 24622842 80 - 0.069 0.208 1.836
ENSG00000107863 E048 0.1451727 0.0431077800 1.000000e+00   10 24629014 24629523 510 - 0.069 0.000 -11.245
ENSG00000107863 E049 1.3921868 0.0096515431 2.492683e-02 6.172313e-02 10 24629524 24629862 339 - 0.181 0.610 2.571
ENSG00000107863 E050 0.1515154 0.0432240398 1.000000e+00   10 24629863 24629995 133 - 0.069 0.000 -11.246
ENSG00000107863 E051 25.8009151 0.0007872058 2.170403e-04 1.036832e-03 10 24629996 24630050 55 - 1.421 1.162 -0.907
ENSG00000107863 E052 35.1001271 0.0094789948 1.358382e-03 5.171131e-03 10 24633402 24633480 79 - 1.543 1.329 -0.741
ENSG00000107863 E053 36.4113211 0.0119708515 1.044889e-02 2.986093e-02 10 24635011 24635103 93 - 1.546 1.389 -0.537
ENSG00000107863 E054 24.0561812 0.0008007789 5.349245e-02 1.153661e-01 10 24666985 24667009 25 - 1.360 1.260 -0.348
ENSG00000107863 E055 38.0828207 0.0007462964 2.669377e-03 9.280361e-03 10 24670218 24670338 121 - 1.563 1.418 -0.496
ENSG00000107863 E056 29.9338030 0.0007139939 5.117974e-05 2.876765e-04 10 24670339 24670397 59 - 1.482 1.214 -0.932
ENSG00000107863 E057 0.0000000       10 24706512 24706630 119 -      
ENSG00000107863 E058 0.0000000       10 24714297 24714378 82 -      
ENSG00000107863 E059 48.3393389 0.0034442447 4.271686e-08 4.672930e-07 10 24721837 24722011 175 - 1.697 1.364 -1.140
ENSG00000107863 E060 48.1985282 0.0043283771 9.325965e-07 7.789675e-06 10 24722012 24722225 214 - 1.691 1.397 -1.005
ENSG00000107863 E061 18.5212781 0.0009975725 9.110576e-04 3.652695e-03 10 24722226 24722279 54 - 1.285 1.009 -0.988
ENSG00000107863 E062 1.9811854 0.1705179992 5.231511e-01 6.568955e-01 10 24722486 24722760 275 - 0.461 0.349 -0.618
ENSG00000107863 E063 1.6104018 0.2307428694 3.264305e-01 4.698757e-01 10 24723157 24723247 91 - 0.434 0.206 -1.500
ENSG00000107863 E064 15.9006224 0.0011601257 9.090308e-05 4.793255e-04 10 24723562 24724088 527 - 1.240 0.854 -1.415