ENSG00000107854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371627 ENSG00000107854 HEK293_OSMI2_2hA HEK293_TMG_2hB TNKS2 protein_coding protein_coding 12.10184 3.620329 19.69974 0.2490813 0.5015701 2.440737 6.951973 0.6718693 15.366101 0.3166418 0.2260841 4.495051 0.4875875 0.1895000 0.78163333 0.59213333 0.0003484433 0.0003484433 FALSE TRUE
MSTRG.4372.3 ENSG00000107854 HEK293_OSMI2_2hA HEK293_TMG_2hB TNKS2 protein_coding   12.10184 3.620329 19.69974 0.2490813 0.5015701 2.440737 2.347794 0.1416604 1.655838 0.1416604 1.4597621 3.457333 0.1149167 0.0416000 0.08326667 0.04166667 0.8432931147 0.0003484433 FALSE TRUE
MSTRG.4372.5 ENSG00000107854 HEK293_OSMI2_2hA HEK293_TMG_2hB TNKS2 protein_coding   12.10184 3.620329 19.69974 0.2490813 0.5015701 2.440737 2.410183 2.5178869 1.979297 0.2207240 1.2385314 -0.345673 0.3661042 0.6987333 0.09953333 -0.59920000 0.0841711434 0.0003484433 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107854 E001 16.030474 0.0010983152 7.660406e-05 4.119683e-04 10 91798426 91798478 53 + 1.088 0.599 -1.920
ENSG00000107854 E002 37.343253 0.0005673770 8.989068e-09 1.117569e-07 10 91798479 91798723 245 + 1.431 0.950 -1.715
ENSG00000107854 E003 14.209912 0.1174890585 5.796419e-02 1.231415e-01 10 91798724 91798732 9 + 1.026 0.777 -0.950
ENSG00000107854 E004 42.145212 0.0005120469 3.500040e-04 1.580135e-03 10 91798733 91798889 157 + 1.463 1.318 -0.502
ENSG00000107854 E005 1.346687 0.1202824726 2.647739e-01 4.027639e-01 10 91798890 91798952 63 + 0.294 0.001 -9.184
ENSG00000107854 E006 72.450195 0.0014986509 9.079716e-04 3.641709e-03 10 91812983 91813207 225 + 1.680 1.629 -0.173
ENSG00000107854 E007 53.997891 0.0004370074 1.893884e-01 3.129688e-01 10 91817134 91817229 96 + 1.540 1.619 0.268
ENSG00000107854 E008 42.300528 0.0005482100 3.543405e-04 1.596935e-03 10 91819270 91819306 37 + 1.463 1.318 -0.502
ENSG00000107854 E009 58.388741 0.0087168725 2.601980e-05 1.571265e-04 10 91819482 91819557 76 + 1.603 1.377 -0.776
ENSG00000107854 E010 69.292208 0.0017011437 6.232928e-07 5.410601e-06 10 91819939 91820033 95 + 1.674 1.473 -0.687
ENSG00000107854 E011 53.964486 0.0043357715 1.161717e-07 1.166439e-06 10 91822296 91822362 67 + 1.578 1.251 -1.131
ENSG00000107854 E012 76.389265 0.0007320979 3.221473e-07 2.961463e-06 10 91827017 91827203 187 + 1.716 1.540 -0.601
ENSG00000107854 E013 55.753442 0.0090186127 3.921152e-03 1.292094e-02 10 91828285 91828406 122 + 1.575 1.487 -0.301
ENSG00000107854 E014 56.506095 0.0013943794 1.421896e-04 7.129313e-04 10 91830923 91831014 92 + 1.583 1.458 -0.426
ENSG00000107854 E015 58.099334 0.0004962111 4.377922e-05 2.501083e-04 10 91831103 91831181 79 + 1.596 1.458 -0.471
ENSG00000107854 E016 101.331947 0.0002952364 1.593277e-07 1.556606e-06 10 91833853 91834024 172 + 1.830 1.703 -0.430
ENSG00000107854 E017 4.127820 0.0042270619 2.651379e-01 4.031655e-01 10 91836796 91836884 89 + 0.578 0.474 -0.491
ENSG00000107854 E018 74.641091 0.0006221033 4.772537e-09 6.253149e-08 10 91836919 91836998 80 + 1.708 1.458 -0.853
ENSG00000107854 E019 90.762122 0.0027870831 1.402425e-05 9.005058e-05 10 91840561 91840706 146 + 1.782 1.668 -0.386
ENSG00000107854 E020 78.021804 0.0004003427 2.459318e-03 8.642056e-03 10 91841283 91841448 166 + 1.708 1.695 -0.046
ENSG00000107854 E021 88.283676 0.0003363066 2.645927e-03 9.209025e-03 10 91842172 91842391 220 + 1.759 1.759 0.001
ENSG00000107854 E022 62.677097 0.0007940372 4.162465e-03 1.359879e-02 10 91844919 91845028 110 + 1.615 1.587 -0.097
ENSG00000107854 E023 103.348653 0.0003142111 2.521955e-02 6.232658e-02 10 91845752 91845940 189 + 1.819 1.876 0.193
ENSG00000107854 E024 135.611435 0.0102949219 1.211593e-01 2.215908e-01 10 91848383 91848635 253 + 1.936 2.003 0.227
ENSG00000107854 E025 83.074739 0.0147547421 3.425834e-01 4.865808e-01 10 91849512 91849594 83 + 1.723 1.819 0.323
ENSG00000107854 E026 107.606043 0.0005723960 5.681134e-01 6.948274e-01 10 91851216 91851336 121 + 1.825 1.969 0.482
ENSG00000107854 E027 95.487010 0.0003679670 9.908758e-01 9.984411e-01 10 91855029 91855126 98 + 1.769 1.940 0.576
ENSG00000107854 E028 93.584938 0.0004635747 1.129776e-01 2.098874e-01 10 91855614 91855688 75 + 1.772 1.859 0.292
ENSG00000107854 E029 97.172921 0.0003270232 6.901757e-01 7.919355e-01 10 91857425 91857530 106 + 1.779 1.930 0.508
ENSG00000107854 E030 112.554529 0.0007767710 7.587623e-03 2.273982e-02 10 91859462 91859648 187 + 1.858 1.893 0.120
ENSG00000107854 E031 102.181964 0.0020871067 1.170304e-01 2.157189e-01 10 91861999 91862155 157 + 1.810 1.894 0.282
ENSG00000107854 E032 791.582205 0.0199153628 4.075806e-12 9.039444e-11 10 91862937 91865475 2539 + 2.607 3.113 1.684