ENSG00000107819

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393459 ENSG00000107819 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN3 protein_coding protein_coding 3.953386 6.159598 2.110872 0.3086232 0.1494955 -1.540519 2.9970335 5.2972838 1.4350711 0.38782095 0.09768648 -1.87683323 0.76775000 0.85790000 0.6829333 -0.17496667 0.01793592 0.01793592 FALSE TRUE
ENST00000465383 ENSG00000107819 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN3 protein_coding processed_transcript 3.953386 6.159598 2.110872 0.3086232 0.1494955 -1.540519 0.2624308 0.2990224 0.3156735 0.03971980 0.08927133 0.07571458 0.06404583 0.04946667 0.1447667 0.09530000 0.05050327 0.01793592 FALSE TRUE
ENST00000470252 ENSG00000107819 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN3 protein_coding processed_transcript 3.953386 6.159598 2.110872 0.3086232 0.1494955 -1.540519 0.3287126 0.3964099 0.2284659 0.05446793 0.08256150 -0.76915267 0.07565833 0.06523333 0.1075000 0.04226667 0.58803686 0.01793592   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107819 E001 24.9796435 0.0009006728 2.725142e-02 6.650049e-02 10 101031234 101031534 301 + 1.445 1.277 -0.582
ENSG00000107819 E002 18.1396046 0.0010967984 8.460746e-02 1.667686e-01 10 101032314 101032482 169 + 1.303 1.150 -0.539
ENSG00000107819 E003 26.6953314 0.0048330736 4.256146e-01 5.685419e-01 10 101034692 101034855 164 + 1.396 1.331 -0.223
ENSG00000107819 E004 30.8371794 0.0187398833 7.557219e-01 8.409798e-01 10 101035497 101035667 171 + 1.374 1.412 0.131
ENSG00000107819 E005 19.3947546 0.0010406480 4.251848e-01 5.681295e-01 10 101036003 101036061 59 + 1.150 1.225 0.267
ENSG00000107819 E006 20.1097299 0.0010957733 2.020355e-01 3.287428e-01 10 101036062 101036101 40 + 1.131 1.252 0.428
ENSG00000107819 E007 27.2132649 0.0010403757 9.363157e-02 1.808030e-01 10 101036486 101036561 76 + 1.454 1.330 -0.428
ENSG00000107819 E008 0.3289534 0.0287300953 3.769947e-01   10 101036667 101036722 56 + 0.203 0.071 -1.749
ENSG00000107819 E009 14.2596489 0.0013252039 5.986525e-03 1.857401e-02 10 101036723 101036727 5 + 1.290 1.032 -0.923
ENSG00000107819 E010 25.2581392 0.0077740745 1.002833e-02 2.883258e-02 10 101036728 101036808 81 + 1.489 1.279 -0.727
ENSG00000107819 E011 32.1926641 0.0006807978 8.857382e-02 1.729420e-01 10 101037076 101037203 128 + 1.514 1.397 -0.400
ENSG00000107819 E012 16.6797456 0.0038428906 6.987973e-01 7.986791e-01 10 101037382 101037391 10 + 1.112 1.151 0.142
ENSG00000107819 E013 20.7739546 0.0041550217 8.515952e-01 9.079769e-01 10 101037392 101037431 40 + 1.248 1.231 -0.060
ENSG00000107819 E014 2.7205855 0.0086413729 9.953406e-02 1.897719e-01 10 101037432 101037507 76 + 0.714 0.443 -1.237
ENSG00000107819 E015 5.3035746 0.0151885883 1.884692e-02 4.899743e-02 10 101037508 101037951 444 + 0.971 0.639 -1.315
ENSG00000107819 E016 7.7895650 0.0024314125 5.332890e-04 2.284248e-03 10 101037952 101038642 691 + 1.150 0.749 -1.509
ENSG00000107819 E017 16.3100203 0.0015755395 7.806057e-01 8.590209e-01 10 101038643 101038692 50 + 1.112 1.140 0.100
ENSG00000107819 E018 18.4628745 0.0203354381 5.896506e-01 7.126918e-01 10 101039175 101039222 48 + 1.132 1.198 0.237
ENSG00000107819 E019 0.6234634 0.0189036155 9.258036e-01 9.572799e-01 10 101039223 101039488 266 + 0.203 0.185 -0.167
ENSG00000107819 E020 219.1745895 0.0003863241 2.983342e-10 4.857630e-09 10 101039489 101041244 1756 + 2.108 2.269 0.538