ENSG00000107816

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370220 ENSG00000107816 HEK293_OSMI2_2hA HEK293_TMG_2hB LZTS2 protein_coding protein_coding 24.53995 38.61001 18.64219 2.530925 0.05961602 -1.050004 1.775094 1.2541224 1.3727568 0.13805638 0.06907634 0.129411295 0.08291667 0.03253333 0.07366667 0.04113333 0.000271540 0.00027154 FALSE TRUE
ENST00000370223 ENSG00000107816 HEK293_OSMI2_2hA HEK293_TMG_2hB LZTS2 protein_coding protein_coding 24.53995 38.61001 18.64219 2.530925 0.05961602 -1.050004 7.873531 13.6851775 4.0391908 1.39926630 0.22829774 -1.757962444 0.30847083 0.35423333 0.21660000 -0.13763333 0.003604463 0.00027154 FALSE TRUE
ENST00000454422 ENSG00000107816 HEK293_OSMI2_2hA HEK293_TMG_2hB LZTS2 protein_coding protein_coding 24.53995 38.61001 18.64219 2.530925 0.05961602 -1.050004 11.102793 20.1888807 10.3970651 2.88665698 0.42121691 -0.956712080 0.42789583 0.51996667 0.55760000 0.03763333 0.816836114 0.00027154 FALSE TRUE
ENST00000481129 ENSG00000107816 HEK293_OSMI2_2hA HEK293_TMG_2hB LZTS2 protein_coding protein_coding 24.53995 38.61001 18.64219 2.530925 0.05961602 -1.050004 1.164663 0.8884675 0.8935148 0.06392585 0.23696869 0.008081969 0.05501250 0.02306667 0.04783333 0.02476667 0.236797246 0.00027154 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107816 E001 0.2214452 0.0374695652 1.000000e+00   10 100996618 100996671 54 + 0.000 0.084 7.970
ENSG00000107816 E002 3.3912915 0.0107824346 2.025828e-01 3.294366e-01 10 100997021 100997071 51 + 0.739 0.550 -0.815
ENSG00000107816 E003 14.9289370 0.0074909320 4.693326e-01 6.085892e-01 10 100997072 100997113 42 + 1.078 1.166 0.317
ENSG00000107816 E004 20.7785511 0.0037511692 2.267862e-01 3.585470e-01 10 100997114 100997175 62 + 1.189 1.309 0.424
ENSG00000107816 E005 24.7753947 0.0089280705 3.318626e-01 4.754946e-01 10 100997176 100997234 59 + 1.277 1.378 0.350
ENSG00000107816 E006 2.9923833 0.0055507568 1.099296e-02 3.114608e-02 10 100998348 100998410 63 + 0.812 0.431 -1.689
ENSG00000107816 E007 9.1496002 0.0026329126 8.286831e-03 2.450963e-02 10 100998687 100998854 168 + 1.145 0.868 -1.022
ENSG00000107816 E008 10.1019164 0.0017006725 9.493668e-03 2.752092e-02 10 100998855 100998981 127 + 1.175 0.915 -0.949
ENSG00000107816 E009 11.7541675 0.0445739962 3.654030e-02 8.460559e-02 10 100999476 100999807 332 + 1.228 0.957 -0.983
ENSG00000107816 E010 34.0023571 0.0006941349 1.478624e-02 4.001155e-02 10 100999808 100999952 145 + 1.584 1.441 -0.490
ENSG00000107816 E011 107.0088432 0.0061491401 8.877628e-12 1.865395e-10 10 100999953 101002496 2544 + 2.192 1.864 -1.100
ENSG00000107816 E012 364.7259892 0.0001737889 6.714634e-03 2.048121e-02 10 101002497 101002946 450 + 2.533 2.492 -0.137
ENSG00000107816 E013 9.3885515 0.0031459344 1.314676e-03 5.026060e-03 10 101002947 101003177 231 + 1.189 0.855 -1.229
ENSG00000107816 E014 672.6456803 0.0001128090 6.926209e-01 7.938091e-01 10 101003507 101004166 660 + 2.763 2.770 0.023
ENSG00000107816 E015 368.9104001 0.0015426758 1.898995e-01 3.136328e-01 10 101005458 101005715 258 + 2.471 2.520 0.163
ENSG00000107816 E016 1137.4580244 0.0014429706 7.756872e-06 5.285269e-05 10 101006485 101007836 1352 + 2.936 3.019 0.273