ENSG00000107779

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372037 ENSG00000107779 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1A protein_coding protein_coding 9.601046 2.250286 15.80227 0.1011821 0.2763243 2.806468 2.62573035 1.1063743 4.203087 0.14722855 0.28864799 1.916057 0.33067917 0.48803333 0.26553333 -0.22250000 9.581152e-04 1.005968e-09 FALSE TRUE
ENST00000635816 ENSG00000107779 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1A protein_coding nonsense_mediated_decay 9.601046 2.250286 15.80227 0.1011821 0.2763243 2.806468 0.88101914 0.2531496 1.777847 0.25314959 0.90199354 2.764269 0.12154583 0.10323333 0.11073333 0.00750000 7.772392e-01 1.005968e-09 TRUE TRUE
ENST00000636056 ENSG00000107779 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1A protein_coding nonsense_mediated_decay 9.601046 2.250286 15.80227 0.1011821 0.2763243 2.806468 0.94997491 0.3270090 0.802584 0.32700897 0.80258403 1.269730 0.09438750 0.15290000 0.05233333 -0.10056667 8.231775e-01 1.005968e-09 TRUE TRUE
ENST00000638429 ENSG00000107779 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1A protein_coding nonsense_mediated_decay 9.601046 2.250286 15.80227 0.1011821 0.2763243 2.806468 0.45074261 0.2069759 0.625115 0.04417481 0.06554511 1.549483 0.07967917 0.09063333 0.03966667 -0.05096667 6.026295e-02 1.005968e-09 TRUE TRUE
MSTRG.4301.13 ENSG00000107779 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1A protein_coding   9.601046 2.250286 15.80227 0.1011821 0.2763243 2.806468 1.83561735 0.2113797 2.687316 0.21137967 0.47969553 3.606930 0.15745833 0.09786667 0.17100000 0.07313333 3.574242e-01 1.005968e-09 TRUE TRUE
MSTRG.4301.3 ENSG00000107779 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1A protein_coding   9.601046 2.250286 15.80227 0.1011821 0.2763243 2.806468 2.15739327 0.0000000 4.736475 0.00000000 0.81697387 8.890713 0.14370833 0.00000000 0.29880000 0.29880000 1.005968e-09 1.005968e-09 TRUE TRUE
MSTRG.4301.8 ENSG00000107779 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1A protein_coding   9.601046 2.250286 15.80227 0.1011821 0.2763243 2.806468 0.02693526 0.1453973 0.000000 0.14539729 0.00000000 -3.957889 0.01224167 0.06733333 0.00000000 -0.06733333 4.585166e-01 1.005968e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107779 E001 0.5932625 0.1937309246 7.285399e-01 8.209800e-01 10 86755770 86755814 45 + 0.185 0.000 -8.858
ENSG00000107779 E002 2.6895454 0.0058190323 2.087676e-01 3.370322e-01 10 86755815 86756104 290 + 0.513 0.254 -1.504
ENSG00000107779 E003 0.4741261 0.0215118812 3.977742e-01 5.415377e-01 10 86756585 86756600 16 + 0.102 0.255 1.584
ENSG00000107779 E004 0.9223296 0.0133046059 9.468652e-01 9.706489e-01 10 86756601 86756618 18 + 0.221 0.254 0.261
ENSG00000107779 E005 1.2210941 0.0106608505 8.667550e-01 9.182444e-01 10 86756619 86756634 16 + 0.286 0.254 -0.224
ENSG00000107779 E006 8.0746548 0.0021709699 6.615342e-03 2.022752e-02 10 86756635 86756749 115 + 0.898 0.414 -2.118
ENSG00000107779 E007 25.5793202 0.0031510606 3.410104e-08 3.799977e-07 10 86756750 86756919 170 + 1.368 0.622 -2.809
ENSG00000107779 E008 0.1451727 0.0439514290 1.000000e+00   10 86838862 86838864 3 + 0.054 0.000 -9.066
ENSG00000107779 E009 31.8080185 0.0153719814 6.287810e-08 6.642911e-07 10 86838865 86838938 74 + 1.459 0.698 -2.801
ENSG00000107779 E010 33.6427690 0.0041568174 3.842171e-06 2.806260e-05 10 86838939 86838979 41 + 1.469 0.990 -1.698
ENSG00000107779 E011 8.9412831 0.0020507068 1.547867e-02 4.158116e-02 10 86843406 86843510 105 + 0.927 0.530 -1.639
ENSG00000107779 E012 82.4981110 0.0003617540 2.720941e-08 3.088706e-07 10 86875867 86876085 219 + 1.838 1.527 -1.054
ENSG00000107779 E013 71.9155254 0.0004926232 5.127762e-05 2.881668e-04 10 86890062 86890224 163 + 1.772 1.547 -0.763
ENSG00000107779 E014 54.1410841 0.0004380307 1.862984e-04 9.049194e-04 10 86892127 86892229 103 + 1.652 1.410 -0.829
ENSG00000107779 E015 57.1091366 0.0008717731 1.450161e-02 3.936730e-02 10 86899794 86899890 97 + 1.663 1.527 -0.465
ENSG00000107779 E016 57.9694681 0.0004227015 2.143335e-03 7.669968e-03 10 86900027 86900126 100 + 1.675 1.495 -0.612
ENSG00000107779 E017 51.6894948 0.0004330641 3.178784e-01 4.607884e-01 10 86912240 86912384 145 + 1.606 1.566 -0.135
ENSG00000107779 E018 53.9472956 0.0054742454 6.556687e-01 7.655038e-01 10 86917134 86917326 193 + 1.620 1.610 -0.032
ENSG00000107779 E019 77.1240104 0.0016806480 7.166524e-01 8.122455e-01 10 86919172 86919469 298 + 1.768 1.772 0.015
ENSG00000107779 E020 83.5469923 0.0003690181 1.706608e-01 2.890186e-01 10 86921520 86921695 176 + 1.811 1.766 -0.151
ENSG00000107779 E021 85.0859930 0.0034160757 5.984585e-01 7.200453e-01 10 86923376 86923506 131 + 1.813 1.810 -0.011
ENSG00000107779 E022 227.4286595 0.0003578748 5.055099e-08 5.445348e-07 10 86923594 86924641 1048 + 2.200 2.374 0.582
ENSG00000107779 E023 189.4952573 0.0043981931 1.766939e-14 5.613582e-13 10 86924642 86927969 3328 + 2.085 2.403 1.063
ENSG00000107779 E024 1.1383756 0.5255413595 2.893330e-01 4.300260e-01 10 86929297 86929299 3 + 0.185 0.534 2.183
ENSG00000107779 E025 7.2885645 0.0043172692 1.185241e-03 4.590982e-03 10 86929300 86929746 447 + 0.698 1.138 1.675
ENSG00000107779 E026 1.2565685 0.0099797301 8.666001e-01 9.181271e-01 10 86929993 86930300 308 + 0.286 0.255 -0.223
ENSG00000107779 E027 25.1625690 0.0105155849 2.515775e-06 1.915234e-05 10 86930301 86932825 2525 + 1.190 1.632 1.531
ENSG00000107779 E028 0.1472490 0.0450268683 1.000000e+00   10 86935618 86935651 34 + 0.054 0.000 -9.059