ENSG00000107771

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000224756 ENSG00000107771 HEK293_OSMI2_2hA HEK293_TMG_2hB CCSER2 protein_coding protein_coding 3.515346 1.906156 4.934924 0.1853373 0.1605819 1.367733 0.37193154 0.1220437 0.6505773 0.0450124 0.10385698 2.322712 0.1095583 0.0643000 0.1332333 0.06893333 2.666617e-01 2.321828e-09 FALSE TRUE
ENST00000359979 ENSG00000107771 HEK293_OSMI2_2hA HEK293_TMG_2hB CCSER2 protein_coding protein_coding 3.515346 1.906156 4.934924 0.1853373 0.1605819 1.367733 0.63322395 0.0000000 0.9040892 0.0000000 0.03588358 6.514263 0.1189083 0.0000000 0.1835333 0.18353333 2.321828e-09 2.321828e-09 FALSE TRUE
ENST00000372088 ENSG00000107771 HEK293_OSMI2_2hA HEK293_TMG_2hB CCSER2 protein_coding protein_coding 3.515346 1.906156 4.934924 0.1853373 0.1605819 1.367733 2.31185686 1.2463478 3.3599208 0.3048249 0.24550481 1.423479 0.6649792 0.6427000 0.6790667 0.03636667 9.717701e-01 2.321828e-09 FALSE TRUE
ENST00000493409 ENSG00000107771 HEK293_OSMI2_2hA HEK293_TMG_2hB CCSER2 protein_coding protein_coding 3.515346 1.906156 4.934924 0.1853373 0.1605819 1.367733 0.07334102 0.3640222 0.0000000 0.1820111 0.00000000 -5.225052 0.0385500 0.2092333 0.0000000 -0.20923333 7.984737e-02 2.321828e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107771 E001 0.1515154 0.0428629818 1.000000e+00   10 84328586 84328588 3 + 0.079 0.000 -9.697
ENSG00000107771 E002 2.4140755 0.0082314321 1.682895e-02 4.455088e-02 10 84328589 84328662 74 + 0.602 0.185 -2.500
ENSG00000107771 E003 8.5135394 0.0432255080 3.741807e-02 8.625662e-02 10 84328663 84328808 146 + 1.017 0.761 -0.979
ENSG00000107771 E004 134.1515703 0.0002602529 8.896325e-13 2.203402e-11 10 84371014 84372469 1456 + 2.141 1.982 -0.535
ENSG00000107771 E005 33.4314090 0.0020874117 2.468514e-02 6.123593e-02 10 84373619 84373815 197 + 1.526 1.440 -0.295
ENSG00000107771 E006 0.0000000       10 84373816 84374005 190 +      
ENSG00000107771 E007 0.1515154 0.0428629818 1.000000e+00   10 84393853 84393942 90 + 0.079 0.000 -11.469
ENSG00000107771 E008 21.2738719 0.0111172146 1.127127e-01 2.095021e-01 10 84417771 84417861 91 + 1.338 1.256 -0.286
ENSG00000107771 E009 0.0000000       10 84424939 84424946 8 +      
ENSG00000107771 E010 0.1817044 0.0390018249 2.147364e-01   10 84424947 84425048 102 + 0.000 0.185 12.602
ENSG00000107771 E011 0.0000000       10 84425182 84425226 45 +      
ENSG00000107771 E012 32.7309881 0.0006942166 3.572455e-01 5.016434e-01 10 84425731 84425893 163 + 1.494 1.502 0.027
ENSG00000107771 E013 12.3351485 0.0017154618 8.490742e-01 9.063249e-01 10 84438512 84438542 31 + 1.072 1.154 0.296
ENSG00000107771 E014 25.6647455 0.0008248264 6.490670e-01 7.604487e-01 10 84438543 84438707 165 + 1.358 1.456 0.340
ENSG00000107771 E015 0.1482932 0.0428465512 2.148739e-01   10 84452217 84452305 89 + 0.000 0.184 12.567
ENSG00000107771 E016 17.3764209 0.0011025922 9.347648e-01 9.629131e-01 10 84463933 84464016 84 + 1.209 1.267 0.204
ENSG00000107771 E017 18.3553480 0.0010479389 1.458360e-01 2.560015e-01 10 84470372 84470458 87 + 1.274 1.214 -0.211
ENSG00000107771 E018 0.1451727 0.0430415745 1.000000e+00   10 84473032 84473146 115 + 0.079 0.000 -11.467
ENSG00000107771 E019 24.9783367 0.0007844933 6.773603e-01 7.820955e-01 10 84477575 84477664 90 + 1.369 1.405 0.124
ENSG00000107771 E020 4.1600810 0.0096791728 6.862083e-01 7.887637e-01 10 84499875 84499959 85 + 0.681 0.674 -0.031
ENSG00000107771 E021 0.0000000       10 84507294 84507333 40 +      
ENSG00000107771 E022 372.2850231 0.0068280412 3.260842e-07 2.994458e-06 10 84513449 84518521 5073 + 2.471 2.658 0.623