ENSG00000107738

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394957 ENSG00000107738 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIR protein_coding protein_coding 0.3337055 0.6403322 0.3073674 0.2314187 0.02588883 -1.035023 0.11999354 0.2605304 0.05247540 0.0374338 0.01269778 -2.1144308 0.5356833 0.5744667 0.17023333 -0.4042333 0.43271784 0.02862245 FALSE TRUE
ENST00000470317 ENSG00000107738 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIR protein_coding processed_transcript 0.3337055 0.6403322 0.3073674 0.2314187 0.02588883 -1.035023 0.11858666 0.1230923 0.23599321 0.1230923 0.04082232 0.8861912 0.2343750 0.1140667 0.75593333 0.6418667 0.02862245 0.02862245 FALSE FALSE
ENST00000481568 ENSG00000107738 HEK293_OSMI2_2hA HEK293_TMG_2hB VSIR protein_coding retained_intron 0.3337055 0.6403322 0.3073674 0.2314187 0.02588883 -1.035023 0.09512527 0.2567095 0.01889876 0.1513848 0.01889876 -3.2061894 0.2299333 0.3114667 0.07383333 -0.2376333 0.39173321 0.02862245 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107738 E001 13.6677111 0.032649190 0.09093188 0.17661601 10 71747556 71750915 3360 - 0.896 1.100 0.753
ENSG00000107738 E002 7.8341580 0.002957408 0.18601394 0.30875798 10 71750916 71751290 375 - 0.960 0.819 -0.539
ENSG00000107738 E003 2.9560369 0.012127938 0.01425750 0.03881141 10 71751668 71751861 194 - 0.778 0.403 -1.709
ENSG00000107738 E004 0.9630129 0.015562664 0.47372834 0.61265369 10 71752975 71753002 28 - 0.352 0.224 -0.885
ENSG00000107738 E005 1.9477942 0.007852157 0.28732266 0.42782017 10 71755359 71755466 108 - 0.211 0.431 1.439
ENSG00000107738 E006 0.0000000       10 71757578 71757630 53 -      
ENSG00000107738 E007 1.2564642 0.014536695 0.66397126 0.77189143 10 71760482 71760867 386 - 0.211 0.305 0.703
ENSG00000107738 E008 2.8356513 0.024822154 0.12824781 0.23170096 10 71760868 71760924 57 - 0.211 0.530 1.935
ENSG00000107738 E009 7.1481084 0.003080834 0.30709712 0.44929746 10 71761598 71762026 429 - 0.677 0.830 0.621
ENSG00000107738 E010 2.0367562 0.009877293 0.03729546 0.08602890 10 71773358 71773520 163 - 0.677 0.339 -1.664