ENSG00000107719

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263563 ENSG00000107719 HEK293_OSMI2_2hA HEK293_TMG_2hB PALD1 protein_coding protein_coding 18.8458 31.04799 11.19445 2.197652 0.1804884 -1.470892 5.9584264 5.4067867 7.5706106 1.5843123 0.7824508 0.4848768 0.33288333 0.17040000 0.67530000 0.5049000 1.419729e-05 1.419729e-05 FALSE TRUE
MSTRG.4120.11 ENSG00000107719 HEK293_OSMI2_2hA HEK293_TMG_2hB PALD1 protein_coding   18.8458 31.04799 11.19445 2.197652 0.1804884 -1.470892 9.3894580 21.0860875 0.7824139 1.3072435 0.7824139 -4.7345776 0.47164167 0.68333333 0.07106667 -0.6122667 1.834866e-02 1.419729e-05 FALSE TRUE
MSTRG.4120.4 ENSG00000107719 HEK293_OSMI2_2hA HEK293_TMG_2hB PALD1 protein_coding   18.8458 31.04799 11.19445 2.197652 0.1804884 -1.470892 1.2354011 2.4425142 0.1880108 0.0518986 0.1880108 -3.6306101 0.05430417 0.07926667 0.01706667 -0.0622000 1.226598e-01 1.419729e-05 FALSE TRUE
MSTRG.4120.5 ENSG00000107719 HEK293_OSMI2_2hA HEK293_TMG_2hB PALD1 protein_coding   18.8458 31.04799 11.19445 2.197652 0.1804884 -1.470892 0.8284069 0.7265283 1.3537834 0.3643106 0.1604869 0.8888017 0.05203333 0.02483333 0.12073333 0.0959000 2.282668e-01 1.419729e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107719 E001 0.6674587 0.0218247667 4.265326e-02 9.591137e-02 10 70478767 70478778 12 + 0.415 0.079 -3.004
ENSG00000107719 E002 2.9506533 0.0071108341 1.985635e-03 7.181608e-03 10 70478779 70478795 17 + 0.836 0.379 -2.072
ENSG00000107719 E003 6.5862702 0.0026755342 6.442304e-07 5.573553e-06 10 70478796 70478815 20 + 1.172 0.600 -2.214
ENSG00000107719 E004 7.2765561 0.0142142185 1.001631e-05 6.655300e-05 10 70478816 70478819 4 + 1.187 0.662 -2.002
ENSG00000107719 E005 10.3411504 0.0020944820 2.263741e-11 4.451053e-10 10 70478820 70478828 9 + 1.378 0.731 -2.387
ENSG00000107719 E006 10.6722939 0.0028957058 2.839773e-11 5.491900e-10 10 70478829 70478829 1 + 1.388 0.746 -2.356
ENSG00000107719 E007 18.4440809 0.0020474165 4.224482e-16 1.673950e-14 10 70478830 70478866 37 + 1.601 0.980 -2.184
ENSG00000107719 E008 55.9539713 0.0110853566 4.072284e-10 6.486313e-09 10 70478867 70479059 193 + 1.948 1.551 -1.344
ENSG00000107719 E009 2.7637495 0.0060726941 4.156535e-02 9.393444e-02 10 70479060 70479170 111 + 0.721 0.414 -1.418
ENSG00000107719 E010 0.6256415 0.0175302823 4.197009e-02 9.466844e-02 10 70482963 70482992 30 + 0.415 0.079 -3.005
ENSG00000107719 E011 0.5181333 0.0214268785 1.414161e-01 2.499731e-01 10 70482993 70482998 6 + 0.315 0.079 -2.419
ENSG00000107719 E012 1.0383430 0.0161716389 3.885794e-02 8.892014e-02 10 70482999 70483007 9 + 0.496 0.146 -2.418
ENSG00000107719 E013 1.9500740 0.0192422717 1.734684e-01 2.927042e-01 10 70483008 70483064 57 + 0.564 0.342 -1.151
ENSG00000107719 E014 147.2495485 0.0051084764 2.455495e-05 1.492512e-04 10 70525923 70526136 214 + 2.211 2.053 -0.526
ENSG00000107719 E015 134.4294768 0.0002601299 2.407592e-06 1.840419e-05 10 70529229 70529331 103 + 2.151 2.024 -0.425
ENSG00000107719 E016 172.8934090 0.0007830419 3.986669e-05 2.298635e-04 10 70529889 70530068 180 + 2.242 2.143 -0.330
ENSG00000107719 E017 161.0238650 0.0002579194 2.185301e-04 1.043160e-03 10 70531290 70531454 165 + 2.199 2.115 -0.280
ENSG00000107719 E018 132.9287871 0.0002324440 1.760388e-03 6.472924e-03 10 70532621 70532714 94 + 2.108 2.032 -0.255
ENSG00000107719 E019 102.0494894 0.0004278445 3.317007e-01 4.753424e-01 10 70532715 70532781 67 + 1.941 1.933 -0.027
ENSG00000107719 E020 108.5038888 0.0003125438 6.491473e-01 7.604910e-01 10 70532995 70533070 76 + 1.951 1.965 0.045
ENSG00000107719 E021 161.3322005 0.0008200023 6.600236e-03 2.018655e-02 10 70533922 70534073 152 + 2.178 2.119 -0.197
ENSG00000107719 E022 138.2360840 0.0014705142 9.399763e-03 2.728042e-02 10 70534425 70534524 100 + 2.117 2.052 -0.219
ENSG00000107719 E023 136.4113390 0.0011222891 1.117840e-02 3.159401e-02 10 70534739 70534843 105 + 2.110 2.049 -0.205
ENSG00000107719 E024 126.7268779 0.0024880685 3.941036e-01 5.379941e-01 10 70537811 70537906 96 + 2.036 2.033 -0.011
ENSG00000107719 E025 88.2251031 0.0035130091 9.230969e-01 9.554976e-01 10 70538280 70538302 23 + 1.856 1.885 0.095
ENSG00000107719 E026 150.1628792 0.0002330905 5.218084e-02 1.130405e-01 10 70538303 70538408 106 + 2.129 2.097 -0.108
ENSG00000107719 E027 167.1034542 0.0002738329 1.335283e-01 2.390435e-01 10 70538892 70539008 117 + 2.161 2.145 -0.053
ENSG00000107719 E028 136.0669133 0.0011817765 8.789093e-01 9.262002e-01 10 70539092 70539154 63 + 2.040 2.067 0.090
ENSG00000107719 E029 154.2491531 0.0002365638 2.121020e-01 3.410146e-01 10 70539155 70539247 93 + 2.056 2.130 0.247
ENSG00000107719 E030 144.9262132 0.0005458021 6.528642e-02 1.355165e-01 10 70539580 70539675 96 + 2.012 2.110 0.331
ENSG00000107719 E031 156.5392712 0.0002414288 1.525726e-02 4.106851e-02 10 70539676 70539762 87 + 2.031 2.146 0.384
ENSG00000107719 E032 194.5305990 0.0029942922 5.161568e-01 6.507201e-01 10 70541102 70541242 141 + 2.173 2.232 0.197
ENSG00000107719 E033 159.3998475 0.0002867257 4.122661e-01 5.558309e-01 10 70541463 70541534 72 + 2.086 2.145 0.197
ENSG00000107719 E034 193.5689796 0.0016418780 6.188277e-02 1.297838e-01 10 70547306 70547446 141 + 2.133 2.233 0.337
ENSG00000107719 E035 25.3650060 0.0080243736 7.303800e-01 8.223579e-01 10 70551037 70551361 325 + 1.348 1.349 0.004
ENSG00000107719 E036 192.7586699 0.0002655881 1.023330e-03 4.039142e-03 10 70564364 70564519 156 + 2.104 2.239 0.450
ENSG00000107719 E037 1348.8977553 0.0025977029 1.438157e-15 5.324687e-14 10 70566581 70568450 1870 + 2.889 3.100 0.703