ENSG00000107679

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368990 ENSG00000107679 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA1 protein_coding protein_coding 9.82024 3.911948 15.82755 0.3677871 0.3765586 2.013707 1.7549928 0.66094022 4.5015509 0.50172313 0.6429502 2.7493673 0.17978333 0.19810000 0.28523333 0.08713333 0.601079124 0.005934319 FALSE  
ENST00000433307 ENSG00000107679 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA1 protein_coding protein_coding 9.82024 3.911948 15.82755 0.3677871 0.3765586 2.013707 0.2890519 1.37500128 0.0000000 0.68762150 0.0000000 -7.1137435 0.07471250 0.32173333 0.00000000 -0.32173333 0.055604813 0.005934319 FALSE  
MSTRG.4755.1 ENSG00000107679 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA1 protein_coding   9.82024 3.911948 15.82755 0.3677871 0.3765586 2.013707 1.8321719 0.52518916 4.7234219 0.52518916 0.6252224 3.1447627 0.16062500 0.12536667 0.30066667 0.17530000 0.209294693 0.005934319 FALSE  
MSTRG.4755.11 ENSG00000107679 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA1 protein_coding   9.82024 3.911948 15.82755 0.3677871 0.3765586 2.013707 0.8827630 0.48249130 0.9254021 0.27355654 0.9254021 0.9254885 0.09868333 0.11216667 0.05793333 -0.05423333 0.465759536 0.005934319 FALSE  
MSTRG.4755.14 ENSG00000107679 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA1 protein_coding   9.82024 3.911948 15.82755 0.3677871 0.3765586 2.013707 0.8436508 0.34534438 0.1422538 0.17267353 0.1422538 -1.2227399 0.08732083 0.09386667 0.00890000 -0.08496667 0.329885309 0.005934319 FALSE  
MSTRG.4755.2 ENSG00000107679 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA1 protein_coding   9.82024 3.911948 15.82755 0.3677871 0.3765586 2.013707 1.4353233 0.00000000 0.7963375 0.00000000 0.7963375 6.3333119 0.12827917 0.00000000 0.04986667 0.04986667 1.000000000 0.005934319 FALSE  
MSTRG.4755.3 ENSG00000107679 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA1 protein_coding   9.82024 3.911948 15.82755 0.3677871 0.3765586 2.013707 0.9418378 0.05520894 1.7517667 0.05520894 0.8761718 4.7558094 0.07246250 0.01733333 0.11143333 0.09410000 0.593133951 0.005934319 FALSE  
MSTRG.4755.6 ENSG00000107679 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA1 protein_coding   9.82024 3.911948 15.82755 0.3677871 0.3765586 2.013707 0.5094745 0.27714868 0.6210585 0.27714868 0.1521824 1.1359759 0.05844167 0.08706667 0.03956667 -0.04750000 0.683440785 0.005934319 FALSE  
MSTRG.4755.9 ENSG00000107679 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHA1 protein_coding   9.82024 3.911948 15.82755 0.3677871 0.3765586 2.013707 0.3716547 0.00000000 0.8887583 0.00000000 0.3245720 6.4898612 0.04177917 0.00000000 0.05520000 0.05520000 0.005934319 0.005934319 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107679 E001 1.3391983 0.0097732613 5.277649e-01 6.607685e-01 10 122374691 122374694 4 + 0.326 0.245 -0.562
ENSG00000107679 E002 1.3391983 0.0097732613 5.277649e-01 6.607685e-01 10 122374695 122374695 1 + 0.326 0.245 -0.562
ENSG00000107679 E003 1.3391983 0.0097732613 5.277649e-01 6.607685e-01 10 122374696 122374700 5 + 0.326 0.245 -0.562
ENSG00000107679 E004 1.9669162 0.0076742087 7.360540e-01 8.266610e-01 10 122374701 122374707 7 + 0.404 0.401 -0.021
ENSG00000107679 E005 2.2572615 0.0064274529 5.630446e-01 6.905803e-01 10 122374708 122374716 9 + 0.450 0.401 -0.262
ENSG00000107679 E006 7.5479861 0.0021954756 2.996333e-02 7.188946e-02 10 122374717 122374733 17 + 0.871 0.605 -1.085
ENSG00000107679 E007 10.5118554 0.0018101631 1.568320e-02 4.202871e-02 10 122374734 122374759 26 + 0.998 0.744 -0.976
ENSG00000107679 E008 19.7863438 0.0023788299 1.028368e-03 4.056578e-03 10 122374760 122374806 47 + 1.246 0.971 -0.995
ENSG00000107679 E009 0.0000000       10 122374807 122374833 27 +      
ENSG00000107679 E010 0.0000000       10 122374834 122374847 14 +      
ENSG00000107679 E011 0.2903454 0.3615125215 1.000000e+00   10 122374848 122374961 114 + 0.107 0.000 -9.729
ENSG00000107679 E012 0.8846520 0.0136293112 9.092832e-01 9.463796e-01 10 122375508 122375512 5 + 0.230 0.245 0.116
ENSG00000107679 E013 1.0329452 0.0120054583 5.469436e-01 6.770218e-01 10 122375513 122375552 40 + 0.230 0.400 1.115
ENSG00000107679 E014 0.4482035 0.0277234451 6.684318e-01 7.754319e-01 10 122386609 122387983 1375 + 0.152 0.000 -11.017
ENSG00000107679 E015 20.5454150 0.0025807719 1.555981e-02 4.175532e-02 10 122392303 122392368 66 + 1.250 1.093 -0.560
ENSG00000107679 E016 12.6414307 0.0061016038 4.898872e-01 6.272568e-01 10 122392369 122392372 4 + 1.027 1.036 0.033
ENSG00000107679 E017 0.1451727 0.0436173608 1.000000e+00   10 122393105 122393127 23 + 0.057 0.000 -9.405
ENSG00000107679 E018 0.2987644 0.0272614198 1.000000e+00   10 122393128 122393180 53 + 0.107 0.000 -10.455
ENSG00000107679 E019 69.6624786 0.0004190298 9.538376e-07 7.946074e-06 10 122393181 122393341 161 + 1.767 1.581 -0.629
ENSG00000107679 E020 58.3791286 0.0004586635 2.095489e-04 1.004745e-03 10 122397918 122397974 57 + 1.683 1.555 -0.438
ENSG00000107679 E021 61.5916560 0.0004322478 7.998337e-06 5.432394e-05 10 122400343 122400388 46 + 1.711 1.536 -0.597
ENSG00000107679 E022 71.5744502 0.0005900324 7.367020e-05 3.977712e-04 10 122406576 122406640 65 + 1.768 1.646 -0.414
ENSG00000107679 E023 50.5403614 0.0004886307 1.038516e-04 5.398075e-04 10 122406641 122406673 33 + 1.626 1.463 -0.556
ENSG00000107679 E024 13.3835581 0.0051103977 4.910602e-03 1.568140e-02 10 122411771 122412919 1149 + 1.091 0.800 -1.092
ENSG00000107679 E025 93.5132675 0.0007579757 6.311894e-05 3.467305e-04 10 122412920 122413045 126 + 1.880 1.784 -0.321
ENSG00000107679 E026 103.2600509 0.0003111003 2.030228e-02 5.211479e-02 10 122415859 122416002 144 + 1.905 1.906 0.004
ENSG00000107679 E027 0.0000000       10 122416003 122416006 4 +      
ENSG00000107679 E028 78.8727261 0.0003236356 5.359282e-01 6.677189e-01 10 122417900 122417968 69 + 1.777 1.850 0.245
ENSG00000107679 E029 4.2605920 0.0039337634 3.088203e-02 7.368770e-02 10 122417969 122424198 6230 + 0.528 0.933 1.673
ENSG00000107679 E030 74.0905787 0.0003532786 3.748771e-01 5.193249e-01 10 122424199 122424263 65 + 1.753 1.811 0.195
ENSG00000107679 E031 72.4518434 0.0003298124 6.982239e-02 1.430835e-01 10 122424896 122424959 64 + 1.754 1.762 0.027
ENSG00000107679 E032 0.5848434 0.0247674011 4.565794e-01 5.969812e-01 10 122424960 122425731 772 + 0.193 0.000 -11.424
ENSG00000107679 E033 64.6539393 0.0004157646 3.070999e-02 7.334739e-02 10 122426942 122427031 90 + 1.713 1.694 -0.061
ENSG00000107679 E034 24.5100451 0.0007693683 3.228690e-03 1.094069e-02 10 122428276 122428316 41 + 1.328 1.142 -0.654
ENSG00000107679 E035 11.8220478 0.0017419249 6.956481e-02 1.426421e-01 10 122428317 122428346 30 + 1.033 0.893 -0.521
ENSG00000107679 E036 12.0259764 0.0015332129 6.172233e-02 1.295248e-01 10 122428347 122428420 74 + 1.038 0.893 -0.541
ENSG00000107679 E037 595.6885144 0.0050084522 2.281363e-19 1.360395e-17 10 122429624 122432354 2731 + 2.587 2.903 1.052