ENSG00000107669

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000224652 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding protein_coding 8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 0.84039962 0.5992369 0.5081058 0.07773150 0.50810579 -0.2337565 0.11840833 0.18103333 0.03506667 -0.14596667 9.442177e-02 6.303442e-14 FALSE TRUE
ENST00000369043 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding protein_coding 8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 2.69917794 0.6947878 4.7334060 0.39258864 0.12724350 2.7506626 0.26686250 0.19476667 0.34193333 0.14716667 6.165963e-01 6.303442e-14 FALSE TRUE
ENST00000423243 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding nonsense_mediated_decay 8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 0.17288392 0.0000000 0.7339288 0.00000000 0.24098003 6.2170926 0.01295833 0.00000000 0.05403333 0.05403333 8.182621e-03 6.303442e-14 FALSE TRUE
ENST00000540606 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding protein_coding 8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 0.27702933 0.0000000 0.8364905 0.00000000 0.12059600 6.4034219 0.02461667 0.00000000 0.05976667 0.05976667 1.678769e-05 6.303442e-14 FALSE TRUE
ENST00000686786 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding nonsense_mediated_decay 8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 0.06951185 0.2861742 0.0000000 0.23927023 0.00000000 -4.8883741 0.02599583 0.09636667 0.00000000 -0.09636667 9.140675e-02 6.303442e-14 FALSE TRUE
ENST00000687458 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding protein_coding 8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 0.32982922 0.6290580 0.1892219 0.09975999 0.07840179 -1.6815704 0.08200417 0.19520000 0.01390000 -0.18130000 4.951718e-05 6.303442e-14 FALSE TRUE
ENST00000689455 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding nonsense_mediated_decay 8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 1.14704117 0.0000000 2.7391617 0.00000000 0.34402463 8.1028479 0.08882500 0.00000000 0.19586667 0.19586667 6.303442e-14 6.303442e-14 FALSE TRUE
ENST00000689571 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding protein_coding 8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 0.07198119 0.2106516 0.0000000 0.08407613 0.00000000 -4.4636984 0.01614583 0.06223333 0.00000000 -0.06223333 1.020820e-04 6.303442e-14 FALSE TRUE
ENST00000690355 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding protein_coding 8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 0.81920733 0.2061560 1.4376579 0.02760210 0.75684264 2.7435760 0.11196667 0.06483333 0.10503333 0.04020000 1.000000e+00 6.303442e-14 FALSE TRUE
MSTRG.4746.62 ENSG00000107669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATE1 protein_coding   8.129353 3.293182 13.87693 0.279022 0.6223597 2.071799 0.17053376 0.0000000 0.7707124 0.00000000 0.43946112 6.2867192 0.01233333 0.00000000 0.05590000 0.05590000 4.160218e-01 6.303442e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107669 E001 0.0000000       10 121709393 121709483 91 -      
ENSG00000107669 E002 1.8414214 0.1819066931 5.873852e-02 1.244697e-01 10 121740424 121740431 8 - 0.264 0.683 2.190
ENSG00000107669 E003 1.8414214 0.1819066931 5.873852e-02 1.244697e-01 10 121740432 121740432 1 - 0.264 0.683 2.190
ENSG00000107669 E004 9.8942647 0.0067035137 4.916200e-06 3.504641e-05 10 121740433 121740474 42 - 0.792 1.312 1.910
ENSG00000107669 E005 27.5040819 0.0015839107 1.493258e-09 2.143292e-08 10 121740475 121740546 72 - 1.245 1.684 1.512
ENSG00000107669 E006 169.7374512 0.0092882179 5.036544e-06 3.582616e-05 10 121740547 121741489 943 - 2.089 2.346 0.856
ENSG00000107669 E007 78.6942209 0.0064846990 2.509168e-01 3.870301e-01 10 121741490 121741853 364 - 1.815 1.906 0.309
ENSG00000107669 E008 147.4751675 0.0003346985 9.341911e-01 9.625210e-01 10 121741854 121742940 1087 - 2.102 2.128 0.088
ENSG00000107669 E009 42.8520785 0.0008105764 1.244103e-02 3.459641e-02 10 121742941 121743183 243 - 1.612 1.469 -0.489
ENSG00000107669 E010 52.6766685 0.0033421812 1.728904e-03 6.374026e-03 10 121743184 121743417 234 - 1.707 1.520 -0.635
ENSG00000107669 E011 25.5045747 0.0553931558 2.742279e-01 4.133602e-01 10 121743418 121743468 51 - 1.388 1.247 -0.491
ENSG00000107669 E012 17.8010770 0.0408625455 3.743852e-01 5.188041e-01 10 121743469 121743472 4 - 1.233 1.119 -0.405
ENSG00000107669 E013 28.9515875 0.0170829672 3.629784e-02 8.414935e-02 10 121743473 121743550 78 - 1.452 1.244 -0.725
ENSG00000107669 E014 18.4192208 0.0009924425 3.017038e-02 7.230379e-02 10 121743551 121743575 25 - 1.266 1.070 -0.698
ENSG00000107669 E015 15.3912613 0.0019237702 4.002697e-03 1.314984e-02 10 121743576 121743576 1 - 1.211 0.900 -1.134
ENSG00000107669 E016 30.8903914 0.0021577426 4.899363e-03 1.564946e-02 10 121743577 121743658 82 - 1.482 1.272 -0.729
ENSG00000107669 E017 30.2247565 0.0006365098 7.658282e-04 3.135457e-03 10 121743659 121743728 70 - 1.479 1.225 -0.884
ENSG00000107669 E018 26.3772782 0.0007340748 1.597985e-03 5.954983e-03 10 121743729 121743791 63 - 1.426 1.173 -0.884
ENSG00000107669 E019 35.3144323 0.0005850314 1.058595e-04 5.489492e-04 10 121743792 121743858 67 - 1.548 1.272 -0.957
ENSG00000107669 E020 5.2260649 0.0035014924 3.163623e-10 5.132204e-09 10 121763476 121763897 422 - 0.369 1.208 3.498
ENSG00000107669 E021 5.9936529 0.0027545968 1.718060e-15 6.301673e-14 10 121763898 121764479 582 - 0.264 1.300 4.499
ENSG00000107669 E022 0.6266857 0.0172671820 2.198767e-01 3.502626e-01 10 121782494 121782699 206 - 0.126 0.355 1.914
ENSG00000107669 E023 0.1817044 0.0441718354 1.214958e-01   10 121789439 121789551 113 - 0.000 0.213 12.298
ENSG00000107669 E024 0.1817044 0.0441718354 1.214958e-01   10 121789552 121790168 617 - 0.000 0.213 12.298
ENSG00000107669 E025 45.5254512 0.0005244545 3.318625e-03 1.120165e-02 10 121790169 121790289 121 - 1.637 1.469 -0.576
ENSG00000107669 E026 0.0000000       10 121790290 121790532 243 -      
ENSG00000107669 E027 52.7008588 0.0008229627 1.893967e-01 3.129771e-01 10 121836718 121836817 100 - 1.678 1.624 -0.182
ENSG00000107669 E028 0.0000000       10 121837340 121837376 37 -      
ENSG00000107669 E029 76.1426740 0.0040517779 1.165735e-02 3.271744e-02 10 121841082 121841259 178 - 1.850 1.727 -0.415
ENSG00000107669 E030 31.2170868 0.0006676440 1.360283e-01 2.425152e-01 10 121841260 121841263 4 - 1.465 1.376 -0.308
ENSG00000107669 E031 0.0000000       10 121841621 121841667 47 -      
ENSG00000107669 E032 0.0000000       10 121841874 121841971 98 -      
ENSG00000107669 E033 0.0000000       10 121845148 121845219 72 -      
ENSG00000107669 E034 0.7437457 0.0153787590 1.000000e+00 1.000000e+00 10 121851295 121851412 118 - 0.223 0.213 -0.087
ENSG00000107669 E035 0.9525055 0.0340047419 5.251150e-01 6.585297e-01 10 121857059 121857606 548 - 0.223 0.355 0.916
ENSG00000107669 E036 41.7322982 0.0005090560 1.170143e-01 2.156945e-01 10 121870006 121870038 33 - 1.584 1.505 -0.272
ENSG00000107669 E037 0.1482932 0.0411597534 1.230427e-01   10 121878333 121878583 251 - 0.000 0.212 12.320
ENSG00000107669 E038 10.7799766 0.0019453780 8.661209e-05 4.592082e-04 10 121888998 121890100 1103 - 0.877 1.300 1.534
ENSG00000107669 E039 58.6784733 0.0030794175 6.722711e-01 7.782886e-01 10 121898841 121898969 129 - 1.714 1.711 -0.009
ENSG00000107669 E040 0.1482932 0.0411597534 1.230427e-01   10 121899313 121899865 553 - 0.000 0.212 12.320
ENSG00000107669 E041 31.5772594 0.0031503435 6.751440e-01 7.805004e-01 10 121899866 121899994 129 - 1.452 1.440 -0.042
ENSG00000107669 E042 72.4116929 0.0003584965 3.766955e-01 5.210180e-01 10 121902391 121902504 114 - 1.788 1.852 0.217
ENSG00000107669 E043 65.6994176 0.0127674467 2.778669e-01 4.174912e-01 10 121902505 121902620 116 - 1.736 1.835 0.336
ENSG00000107669 E044 2.1979383 0.0106166496 5.626130e-01 6.901854e-01 10 121910413 121910905 493 - 0.428 0.547 0.592
ENSG00000107669 E045 102.5666889 0.0003094157 9.006848e-01 9.406537e-01 10 121910906 121911112 207 - 1.948 1.967 0.061
ENSG00000107669 E046 56.2150580 0.0005580832 9.401390e-01 9.663945e-01 10 121911113 121911151 39 - 1.688 1.707 0.063
ENSG00000107669 E047 58.2517863 0.0004954514 3.227306e-01 4.660656e-01 10 121913790 121913893 104 - 1.716 1.685 -0.105
ENSG00000107669 E048 2.2122025 0.0325924903 1.559360e-05 9.912628e-05 10 121917529 121922348 4820 - 0.126 0.867 4.246
ENSG00000107669 E049 46.4791812 0.0004967826 6.579746e-01 7.672267e-01 10 121922349 121922411 63 - 1.601 1.649 0.165
ENSG00000107669 E050 50.7825738 0.0004904004 6.141599e-02 1.290149e-01 10 121924266 121924329 64 - 1.671 1.583 -0.301
ENSG00000107669 E051 4.7073882 0.0076204973 7.424815e-01 8.313635e-01 10 121926423 121926733 311 - 0.715 0.680 -0.145
ENSG00000107669 E052 5.7165744 0.0028821706 3.963427e-01 5.401162e-01 10 121926734 121926995 262 - 0.792 0.681 -0.454
ENSG00000107669 E053 2.8570797 0.0600215048 6.729587e-01 7.787568e-01 10 121926996 121927137 142 - 0.546 0.464 -0.396
ENSG00000107669 E054 1.5219468 0.0100025484 5.562474e-01 6.849305e-01 10 121927138 121927317 180 - 0.337 0.461 0.691
ENSG00000107669 E055 1.9669162 0.0083131105 5.586957e-01 6.868923e-01 10 121927503 121927843 341 - 0.454 0.355 -0.546
ENSG00000107669 E056 37.6344035 0.0031207092 1.137512e-01 2.109971e-01 10 121927844 121928075 232 - 1.544 1.450 -0.324
ENSG00000107669 E057 7.3375817 0.0033641951 5.563556e-01 6.850238e-01 10 121928347 121928801 455 - 0.837 0.934 0.371