ENSG00000107651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369075 ENSG00000107651 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC23IP protein_coding protein_coding 26.62709 14.21128 35.95878 1.41463 0.9604141 1.338694 4.884782 3.96289893 6.443851 0.34956671 0.3767230 0.6999682 0.21057500 0.280700000 0.17916667 -0.10153333 2.860304e-03 3.269007e-14 FALSE TRUE
ENST00000442952 ENSG00000107651 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC23IP protein_coding protein_coding 26.62709 14.21128 35.95878 1.41463 0.9604141 1.338694 1.531773 1.40423403 0.901542 0.02569524 0.2408365 -0.6336398 0.09880000 0.100600000 0.02503333 -0.07556667 3.192237e-04 3.269007e-14 FALSE TRUE
ENST00000446561 ENSG00000107651 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC23IP protein_coding protein_coding 26.62709 14.21128 35.95878 1.41463 0.9604141 1.338694 2.748723 0.09986395 4.911757 0.09986395 0.8065037 5.4853833 0.06775833 0.007066667 0.13586667 0.12880000 5.780681e-03 3.269007e-14 FALSE FALSE
ENST00000475542 ENSG00000107651 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC23IP protein_coding processed_transcript 26.62709 14.21128 35.95878 1.41463 0.9604141 1.338694 4.395611 3.23488772 4.348926 0.89956583 0.7509406 0.4258043 0.15501250 0.219333333 0.12126667 -0.09806667 1.975045e-01 3.269007e-14 FALSE TRUE
MSTRG.4735.3 ENSG00000107651 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC23IP protein_coding   26.62709 14.21128 35.95878 1.41463 0.9604141 1.338694 1.369463 0.00000000 2.729573 0.00000000 0.3165398 8.0978073 0.04100833 0.000000000 0.07646667 0.07646667 3.269007e-14 3.269007e-14 TRUE TRUE
MSTRG.4735.4 ENSG00000107651 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC23IP protein_coding   26.62709 14.21128 35.95878 1.41463 0.9604141 1.338694 6.500339 0.73535780 10.170962 0.73535780 0.4656351 3.7717970 0.19745000 0.051966667 0.28276667 0.23080000 7.857882e-02 3.269007e-14 TRUE TRUE
MSTRG.4735.7 ENSG00000107651 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC23IP protein_coding   26.62709 14.21128 35.95878 1.41463 0.9604141 1.338694 4.690166 4.03362025 5.834976 0.57349704 0.4965826 0.5315496 0.20028750 0.286600000 0.16223333 -0.12436667 5.044988e-02 3.269007e-14 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107651 E001 1.2597882 0.2580113051 7.037949e-01 8.024408e-01 10 119892683 119892704 22 + 0.278 0.396 0.733
ENSG00000107651 E002 3.8514024 0.0631938395 2.859458e-01 4.263095e-01 10 119892705 119892717 13 + 0.720 0.532 -0.824
ENSG00000107651 E003 4.7286780 0.0235105813 6.012251e-01 7.223555e-01 10 119892718 119892725 8 + 0.755 0.683 -0.298
ENSG00000107651 E004 5.3198788 0.0031659335 1.162604e-01 2.146267e-01 10 119892726 119892729 4 + 0.847 0.635 -0.863
ENSG00000107651 E005 5.3198788 0.0031659335 1.162604e-01 2.146267e-01 10 119892730 119892730 1 + 0.847 0.635 -0.863
ENSG00000107651 E006 10.5168472 0.0349755229 1.689151e-01 2.867656e-01 10 119892731 119892739 9 + 1.102 0.911 -0.703
ENSG00000107651 E007 23.4687458 0.0070734061 9.488296e-03 2.750745e-02 10 119892740 119892744 5 + 1.437 1.221 -0.753
ENSG00000107651 E008 136.4599328 0.0162871712 5.312100e-04 2.276424e-03 10 119892745 119892945 201 + 2.193 1.955 -0.799
ENSG00000107651 E009 10.1813487 0.0084421232 1.788190e-01 2.996588e-01 10 119898244 119898426 183 + 1.078 0.934 -0.531
ENSG00000107651 E010 116.8950564 0.0015831828 3.878144e-08 4.275256e-07 10 119898427 119898518 92 + 2.119 1.909 -0.704
ENSG00000107651 E011 169.2938467 0.0003199957 5.117501e-11 9.494616e-10 10 119898519 119898740 222 + 2.273 2.091 -0.611
ENSG00000107651 E012 154.3141316 0.0002775203 4.259001e-07 3.820155e-06 10 119898741 119898959 219 + 2.222 2.082 -0.469
ENSG00000107651 E013 50.5813211 0.0004808650 1.054667e-01 1.988075e-01 10 119902799 119902806 8 + 1.721 1.654 -0.229
ENSG00000107651 E014 94.9565313 0.0003222189 2.508652e-05 1.520529e-04 10 119902807 119902900 94 + 2.015 1.866 -0.501
ENSG00000107651 E015 126.9213838 0.0012082792 2.580109e-07 2.419652e-06 10 119902901 119903009 109 + 2.147 1.968 -0.600
ENSG00000107651 E016 148.2471713 0.0002155153 3.051910e-09 4.133662e-08 10 119904084 119904193 110 + 2.213 2.041 -0.575
ENSG00000107651 E017 142.8348072 0.0007373236 2.821390e-05 1.688679e-04 10 119904194 119904277 84 + 2.182 2.056 -0.422
ENSG00000107651 E018 13.3632141 0.0014072894 1.251173e-11 2.564161e-10 10 119904278 119904662 385 + 0.788 1.440 2.367
ENSG00000107651 E019 130.1348991 0.0106768913 5.800441e-03 1.808790e-02 10 119909041 119909130 90 + 2.150 1.993 -0.525
ENSG00000107651 E020 162.9226307 0.0042935669 1.178068e-04 6.038134e-04 10 119912044 119912164 121 + 2.248 2.093 -0.517
ENSG00000107651 E021 0.4031496 0.0280147838 6.777796e-02 1.396766e-01 10 119914500 119914729 230 + 0.000 0.290 12.297
ENSG00000107651 E022 138.5231890 0.0009761058 1.034507e-03 4.077823e-03 10 119914730 119914819 90 + 2.165 2.069 -0.320
ENSG00000107651 E023 163.8108517 0.0002098309 5.777619e-03 1.802741e-02 10 119915748 119915889 142 + 2.226 2.163 -0.211
ENSG00000107651 E024 158.9902146 0.0002462799 7.002531e-02 1.434078e-01 10 119917836 119918044 209 + 2.202 2.166 -0.122
ENSG00000107651 E025 126.6722695 0.0031077756 7.604608e-01 8.445716e-01 10 119918393 119918511 119 + 2.090 2.092 0.006
ENSG00000107651 E026 171.7947744 0.0002333849 1.848296e-03 6.753215e-03 10 119919444 119919596 153 + 2.249 2.177 -0.242
ENSG00000107651 E027 154.4636950 0.0002110568 1.797806e-05 1.126883e-04 10 119920889 119920984 96 + 2.216 2.102 -0.381
ENSG00000107651 E028 203.1634763 0.0051045189 7.893883e-02 1.578225e-01 10 119926036 119926227 192 + 2.316 2.252 -0.213
ENSG00000107651 E029 89.0094746 0.0050373196 1.392976e-01 2.470905e-01 10 119929607 119929644 38 + 1.961 1.898 -0.214
ENSG00000107651 E030 166.2773814 0.0022671618 7.762447e-01 8.559294e-01 10 119929645 119929762 118 + 2.207 2.210 0.012
ENSG00000107651 E031 161.4224770 0.0013334690 5.645835e-01 6.918450e-01 10 119930329 119930431 103 + 2.183 2.217 0.114
ENSG00000107651 E032 214.6804007 0.0002111378 3.116043e-02 7.421084e-02 10 119932133 119932318 186 + 2.293 2.365 0.239
ENSG00000107651 E033 74.9901132 0.0010664338 7.792567e-02 1.561484e-01 10 119933005 119933007 3 + 1.834 1.930 0.322
ENSG00000107651 E034 187.7277138 0.0001863075 3.121740e-07 2.877880e-06 10 119933008 119933167 160 + 2.201 2.353 0.508
ENSG00000107651 E035 157.1504105 0.0040075512 2.163794e-04 1.034222e-03 10 119933686 119933785 100 + 2.115 2.283 0.560
ENSG00000107651 E036 71.7333203 0.0003808969 5.263142e-03 1.664752e-02 10 119933786 119933787 2 + 1.793 1.929 0.458
ENSG00000107651 E037 253.5908826 0.0001646708 1.078634e-05 7.112812e-05 10 119940586 119940792 207 + 2.345 2.463 0.393
ENSG00000107651 E038 257.4226727 0.0015957206 3.688187e-10 5.915807e-09 10 119940793 119941111 319 + 2.316 2.513 0.657
ENSG00000107651 E039 155.0158756 0.0009030685 6.887811e-08 7.218827e-07 10 119941112 119941180 69 + 2.103 2.290 0.628
ENSG00000107651 E040 190.4650630 0.0055584633 6.254891e-05 3.439482e-04 10 119941181 119941308 128 + 2.186 2.383 0.658
ENSG00000107651 E041 303.2336128 0.0078309670 1.662893e-14 5.312479e-13 10 119941309 119942173 865 + 2.292 2.669 1.256
ENSG00000107651 E042 18.3145969 0.0108338661 3.507425e-01 4.949248e-01 10 119942174 119942892 719 + 1.296 1.221 -0.267
ENSG00000107651 E043 47.5451687 0.0004563765 1.034773e-04 5.380983e-04 10 119942893 119944657 1765 + 1.584 1.800 0.733
ENSG00000107651 E044 0.2987644 0.0275065643 4.823303e-01   10 119949044 119949102 59 + 0.161 0.000 -10.401
ENSG00000107651 E045 0.4482035 0.0274867494 2.681341e-01 4.065630e-01 10 119949257 119949383 127 + 0.223 0.000 -10.986
ENSG00000107651 E046 0.5827671 0.1162472801 1.864896e-01 3.093456e-01 10 119949987 119950083 97 + 0.277 0.000 -11.398
ENSG00000107651 E047 0.7321030 0.0933200210 9.945823e-02 1.896553e-01 10 119951401 119951429 29 + 0.088 0.386 2.681