ENSG00000107643

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374174 ENSG00000107643 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK8 protein_coding processed_transcript 10.8487 2.511735 18.37352 0.2384879 0.7246938 2.865924 1.7561836 0.00000000 2.8543992 0.00000000 0.35844504 8.162089 0.10717500 0.00000000 0.15496667 0.15496667 2.289498e-09 2.289498e-09 FALSE TRUE
ENST00000374189 ENSG00000107643 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK8 protein_coding protein_coding 10.8487 2.511735 18.37352 0.2384879 0.7246938 2.865924 0.5312832 0.27510675 0.8818540 0.14106026 0.08754898 1.645305 0.04887917 0.09986667 0.04790000 -0.05196667 6.652527e-01 2.289498e-09 FALSE TRUE
ENST00000395611 ENSG00000107643 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK8 protein_coding protein_coding 10.8487 2.511735 18.37352 0.2384879 0.7246938 2.865924 0.3357021 0.00000000 0.9266346 0.00000000 0.19510501 6.549414 0.03624583 0.00000000 0.05040000 0.05040000 2.257660e-03 2.289498e-09 FALSE TRUE
ENST00000432379 ENSG00000107643 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK8 protein_coding protein_coding 10.8487 2.511735 18.37352 0.2384879 0.7246938 2.865924 1.8373264 0.17442977 3.9795588 0.17442977 0.18589168 4.435086 0.12134583 0.06476667 0.21736667 0.15260000 1.852821e-01 2.289498e-09 FALSE FALSE
ENST00000471272 ENSG00000107643 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK8 protein_coding retained_intron 10.8487 2.511735 18.37352 0.2384879 0.7246938 2.865924 0.9531668 0.06218588 1.3330806 0.06218588 0.24084214 4.217685 0.07384583 0.02310000 0.07376667 0.05066667 3.070255e-01 2.289498e-09 FALSE TRUE
ENST00000476134 ENSG00000107643 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK8 protein_coding protein_coding 10.8487 2.511735 18.37352 0.2384879 0.7246938 2.865924 0.3324202 0.20715984 0.7988360 0.10627443 0.37299993 1.897090 0.06638333 0.08763333 0.04200000 -0.04563333 8.398164e-01 2.289498e-09 FALSE TRUE
MSTRG.3948.4 ENSG00000107643 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK8 protein_coding   10.8487 2.511735 18.37352 0.2384879 0.7246938 2.865924 2.0898793 0.82308685 3.0994142 0.18871415 0.37502749 1.900104 0.19055417 0.33193333 0.17066667 -0.16126667 1.738186e-01 2.289498e-09 FALSE TRUE
MSTRG.3948.5 ENSG00000107643 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK8 protein_coding   10.8487 2.511735 18.37352 0.2384879 0.7246938 2.865924 0.9696420 0.57801711 2.1775482 0.03237026 0.08069759 1.895385 0.11826667 0.23206667 0.11910000 -0.11296667 6.180657e-03 2.289498e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107643 E001 0.0000000       10 48306639 48306654 16 +      
ENSG00000107643 E002 0.1817044 0.0491680064 9.937152e-02   10 48306655 48306661 7 + 0.000 0.224 11.295
ENSG00000107643 E003 0.3268771 0.0289067718 2.953981e-01   10 48306662 48306662 1 + 0.063 0.224 2.107
ENSG00000107643 E004 0.7686241 0.1495425580 9.569127e-01 9.769656e-01 10 48306663 48306676 14 + 0.211 0.224 0.110
ENSG00000107643 E005 0.9158732 0.2769190079 1.000000e+00 1.000000e+00 10 48306677 48306679 3 + 0.251 0.225 -0.208
ENSG00000107643 E006 4.5415665 0.0036216924 4.767117e-02 1.050306e-01 10 48306680 48306693 14 + 0.732 0.371 -1.701
ENSG00000107643 E007 17.4549978 0.0021632553 1.223233e-01 2.232584e-01 10 48306694 48306752 59 + 1.218 1.072 -0.524
ENSG00000107643 E008 27.5332966 0.0039247931 3.359960e-02 7.896566e-02 10 48306753 48306821 69 + 1.411 1.235 -0.614
ENSG00000107643 E009 0.0000000       10 48307026 48307147 122 +      
ENSG00000107643 E010 24.6993445 0.0008504887 1.114638e-01 2.076964e-01 10 48308095 48308215 121 + 1.358 1.236 -0.428
ENSG00000107643 E011 23.8144519 0.0087481973 1.532482e-01 2.660961e-01 10 48308216 48308288 73 + 1.343 1.217 -0.439
ENSG00000107643 E012 19.0528027 0.0013567330 2.371373e-02 5.922368e-02 10 48325897 48325965 69 + 1.265 1.046 -0.782
ENSG00000107643 E013 0.2966881 0.0271875126 1.000000e+00   10 48364612 48364656 45 + 0.119 0.000 -12.886
ENSG00000107643 E014 31.6837054 0.0006008564 1.971239e-02 5.087949e-02 10 48401612 48401642 31 + 1.468 1.299 -0.587
ENSG00000107643 E015 25.0286713 0.0009651668 5.407105e-03 1.703320e-02 10 48401643 48401647 5 + 1.381 1.141 -0.846
ENSG00000107643 E016 29.8279345 0.0006984308 1.682844e-01 2.859690e-01 10 48401648 48401660 13 + 1.432 1.341 -0.316
ENSG00000107643 E017 63.3858810 0.0020905283 5.454514e-02 1.171946e-01 10 48401661 48401782 122 + 1.750 1.652 -0.333
ENSG00000107643 E018 68.2076708 0.0145439901 2.937738e-01 4.348237e-01 10 48404852 48404981 130 + 1.776 1.696 -0.272
ENSG00000107643 E019 59.2272921 0.0050556599 7.444739e-02 1.506514e-01 10 48409879 48409937 59 + 1.720 1.611 -0.369
ENSG00000107643 E020 81.4543059 0.0011155418 2.182819e-01 3.483413e-01 10 48410030 48410168 139 + 1.844 1.800 -0.149
ENSG00000107643 E021 2.1153085 0.0118603193 3.389540e-01 4.828578e-01 10 48410169 48410328 160 + 0.382 0.569 0.937
ENSG00000107643 E022 92.6867084 0.0002930993 1.018760e-01 1.933529e-01 10 48420155 48420320 166 + 1.903 1.848 -0.185
ENSG00000107643 E023 10.3645913 0.0426342858 9.860106e-01 9.952674e-01 10 48424088 48424159 72 + 0.984 1.012 0.103
ENSG00000107643 E024 41.4076007 0.0005265390 7.567141e-02 1.525823e-01 10 48424514 48424518 5 + 1.571 1.468 -0.354
ENSG00000107643 E025 53.2127316 0.0004653490 4.350998e-02 9.748490e-02 10 48424519 48424568 50 + 1.677 1.573 -0.354
ENSG00000107643 E026 31.9503372 0.0006826327 2.009228e-01 3.273383e-01 10 48424569 48424585 17 + 1.459 1.379 -0.275
ENSG00000107643 E027 2.2133430 0.0066002226 2.183923e-02 5.534358e-02 10 48425179 48425188 10 + 0.525 0.000 -15.795
ENSG00000107643 E028 2.3595598 0.0063603704 1.334939e-01 2.389931e-01 10 48425189 48425219 31 + 0.525 0.224 -1.801
ENSG00000107643 E029 6.8236061 0.0027942744 1.150399e-01 2.128955e-01 10 48425220 48425749 530 + 0.871 0.641 -0.931
ENSG00000107643 E030 3.8490139 0.0045906819 2.759858e-01 4.153864e-01 10 48425750 48425853 104 + 0.663 0.481 -0.834
ENSG00000107643 E031 1.9261301 0.0082928361 7.621949e-01 8.458507e-01 10 48425854 48425887 34 + 0.410 0.480 0.367
ENSG00000107643 E032 91.5913301 0.0002950594 5.041098e-01 6.400044e-01 10 48425888 48426043 156 + 1.891 1.880 -0.037
ENSG00000107643 E033 53.3246699 0.0020543423 7.263768e-01 8.194237e-01 10 48426044 48426070 27 + 1.657 1.652 -0.017
ENSG00000107643 E034 1.7005031 0.0176796884 1.428809e-01 2.519627e-01 10 48426071 48426379 309 + 0.288 0.569 1.525
ENSG00000107643 E035 88.7022790 0.0003120925 8.385877e-01 8.990981e-01 10 48426380 48426504 125 + 1.868 1.896 0.093
ENSG00000107643 E036 8.2926597 0.0020689558 5.933693e-01 7.157813e-01 10 48426505 48427079 575 + 0.906 0.850 -0.216
ENSG00000107643 E037 68.2036349 0.0003822324 4.075621e-02 9.242669e-02 10 48427080 48427143 64 + 1.734 1.852 0.400
ENSG00000107643 E038 0.9943357 0.0133914886 4.253353e-01 5.682786e-01 10 48427144 48427410 267 + 0.211 0.371 1.107
ENSG00000107643 E039 8.3947519 0.0020664267 1.496177e-01 2.611550e-01 10 48429893 48431192 1300 + 0.852 1.046 0.727
ENSG00000107643 E040 72.0888565 0.0003721869 3.625326e-01 5.069473e-01 10 48431193 48431270 78 + 1.769 1.831 0.211
ENSG00000107643 E041 35.1140925 0.0011424003 7.385167e-02 1.496728e-01 10 48434879 48434883 5 + 1.442 1.581 0.478
ENSG00000107643 E042 453.7579700 0.0019202583 1.438023e-09 2.069502e-08 10 48434884 48439360 4477 + 2.541 2.692 0.505