ENSG00000107625

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373585 ENSG00000107625 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX50 protein_coding protein_coding 27.76374 12.52778 39.95168 1.742551 1.067006 1.672335 17.688236 8.4495119 23.9188808 0.6649963 1.1075831 1.500107 0.64692083 0.6931000 0.5995333 -0.09356667 0.671173849 0.001631739 FALSE TRUE
ENST00000466265 ENSG00000107625 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX50 protein_coding processed_transcript 27.76374 12.52778 39.95168 1.742551 1.067006 1.672335 1.164932 2.2867877 0.2553058 1.4194113 0.1458984 -3.113890 0.08267917 0.1605667 0.0063000 -0.15426667 0.412206569 0.001631739 FALSE TRUE
MSTRG.4093.1 ENSG00000107625 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX50 protein_coding   27.76374 12.52778 39.95168 1.742551 1.067006 1.672335 1.586915 0.2848493 2.7786175 0.1428536 0.4329738 3.241500 0.05304583 0.0214000 0.0698000 0.04840000 0.217139803 0.001631739 TRUE TRUE
MSTRG.4093.2 ENSG00000107625 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX50 protein_coding   27.76374 12.52778 39.95168 1.742551 1.067006 1.672335 5.160485 0.7932745 8.7385198 0.1050275 1.1761019 3.445074 0.15147917 0.0677000 0.2183333 0.15063333 0.001631739 0.001631739 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107625 E001 1.9262173 0.0079929467 4.780713e-01 6.165212e-01 10 68901252 68901267 16 + 0.460 0.327 -0.748
ENSG00000107625 E002 2.2530943 0.0065779275 7.400952e-01 8.296045e-01 10 68901268 68901272 5 + 0.488 0.429 -0.301
ENSG00000107625 E003 10.0664311 0.0017421914 5.511447e-02 1.181941e-01 10 68901273 68901285 13 + 1.056 0.820 -0.887
ENSG00000107625 E004 27.9984886 0.0006980326 2.018380e-05 1.250575e-04 10 68901286 68901314 29 + 1.497 1.143 -1.235
ENSG00000107625 E005 29.2110498 0.0006704926 1.331302e-05 8.593518e-05 10 68901315 68901316 2 + 1.515 1.160 -1.235
ENSG00000107625 E006 143.0440647 0.0003212980 7.605438e-12 1.614372e-10 10 68901317 68901471 155 + 2.174 1.927 -0.827
ENSG00000107625 E007 11.9417161 0.0018137980 3.586275e-01 5.030201e-01 10 68902271 68902426 156 + 1.097 0.999 -0.358
ENSG00000107625 E008 16.2459763 0.0011153605 8.357428e-05 4.449318e-04 10 68906226 68906283 58 + 1.286 0.856 -1.569
ENSG00000107625 E009 18.6640401 0.0026310541 1.833908e-05 1.147462e-04 10 68906284 68906337 54 + 1.345 0.888 -1.651
ENSG00000107625 E010 263.0234208 0.0024466794 6.294402e-09 8.063670e-08 10 68906711 68907007 297 + 2.429 2.227 -0.675
ENSG00000107625 E011 122.7929888 0.0002907261 1.391434e-07 1.375727e-06 10 68910307 68910382 76 + 2.099 1.901 -0.667
ENSG00000107625 E012 178.4442412 0.0002221305 7.824092e-07 6.648951e-06 10 68911068 68911246 179 + 2.251 2.101 -0.502
ENSG00000107625 E013 132.0841374 0.0022475107 1.499407e-02 4.047452e-02 10 68913162 68913279 118 + 2.110 2.010 -0.336
ENSG00000107625 E014 0.4804688 0.0216023831 7.438907e-01 8.323964e-01 10 68913350 68913390 41 + 0.139 0.194 0.575
ENSG00000107625 E015 78.1607880 0.0040680690 1.708914e-01 2.893376e-01 10 68913391 68913426 36 + 1.878 1.804 -0.249
ENSG00000107625 E016 167.0522231 0.0003384627 1.136119e-01 2.107992e-01 10 68913427 68913576 150 + 2.198 2.152 -0.154
ENSG00000107625 E017 184.0217403 0.0007802650 8.345638e-01 8.964390e-01 10 68914059 68914204 146 + 2.224 2.233 0.030
ENSG00000107625 E018 97.7673926 0.0003137808 8.453920e-01 9.038612e-01 10 68919832 68919853 22 + 1.952 1.963 0.038
ENSG00000107625 E019 191.2372622 0.0002016502 4.462815e-01 5.877788e-01 10 68919854 68919981 128 + 2.248 2.230 -0.060
ENSG00000107625 E020 199.1954720 0.0003509806 9.009081e-01 9.408003e-01 10 68934199 68934360 162 + 2.259 2.266 0.023
ENSG00000107625 E021 139.5155388 0.0004248838 1.389950e-01 2.467108e-01 10 68934799 68934918 120 + 2.090 2.143 0.177
ENSG00000107625 E022 110.0828602 0.0003315679 3.176996e-01 4.605907e-01 10 68936006 68936079 74 + 1.991 2.032 0.136
ENSG00000107625 E023 188.7147031 0.0046028026 2.531390e-02 6.252222e-02 10 68936936 68937095 160 + 2.207 2.308 0.339
ENSG00000107625 E024 223.6796534 0.0002370203 5.221353e-08 5.609128e-07 10 68941060 68941194 135 + 2.268 2.408 0.470
ENSG00000107625 E025 159.2686619 0.0002418936 1.393643e-06 1.121427e-05 10 68943213 68943257 45 + 2.119 2.266 0.492
ENSG00000107625 E026 352.8707425 0.0004469347 8.499031e-21 5.994475e-19 10 68946352 68946720 369 + 2.444 2.642 0.658
ENSG00000107625 E027 88.0667667 0.0080961159 2.332835e-05 1.424262e-04 10 68946721 68946847 127 + 1.824 2.076 0.845
ENSG00000107625 E028 0.7728905 0.0145404127 7.989547e-01 8.717213e-01 10 68947965 68948040 76 + 0.244 0.194 -0.424