ENSG00000107554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324109 ENSG00000107554 HEK293_OSMI2_2hA HEK293_TMG_2hB DNMBP protein_coding protein_coding 4.697496 5.550934 3.408426 0.1948169 0.09258539 -0.7019949 2.880077 2.222018 2.8632041 0.4366727 0.07522253 0.364312 0.6529375 0.3970333 0.8418000 0.4447667 9.281040e-05 1.115385e-05 FALSE TRUE
ENST00000543621 ENSG00000107554 HEK293_OSMI2_2hA HEK293_TMG_2hB DNMBP protein_coding protein_coding 4.697496 5.550934 3.408426 0.1948169 0.09258539 -0.7019949 1.707220 3.265878 0.4531765 0.3207590 0.10831062 -2.822248 0.3246250 0.5921000 0.1315333 -0.4605667 1.115385e-05 1.115385e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107554 E001 266.5082888 0.0086093602 2.443190e-10 4.031135e-09 10 99875577 99877042 1466 - 2.216 2.498 0.943
ENSG00000107554 E002 63.7704709 0.0020188533 1.556758e-01 2.693214e-01 10 99877043 99877336 294 - 1.736 1.833 0.325
ENSG00000107554 E003 91.1095360 0.0003787497 3.127279e-01 4.552504e-01 10 99879811 99880361 551 - 1.905 1.969 0.218
ENSG00000107554 E004 37.2563313 0.0005670685 7.307033e-01 8.225445e-01 10 99884011 99884209 199 - 1.538 1.585 0.160
ENSG00000107554 E005 35.2426112 0.0006104316 4.431299e-01 5.846970e-01 10 99885687 99885866 180 - 1.557 1.539 -0.061
ENSG00000107554 E006 21.1886127 0.0009438286 7.703177e-01 8.516642e-01 10 99886300 99886403 104 - 1.330 1.335 0.017
ENSG00000107554 E007 34.1036665 0.0006663652 9.437680e-01 9.687162e-01 10 99886404 99886632 229 - 1.513 1.535 0.078
ENSG00000107554 E008 30.3121700 0.0007103049 6.874187e-01 7.897718e-01 10 99888825 99888953 129 - 1.446 1.499 0.181
ENSG00000107554 E009 0.8104664 0.0156936661 9.966429e-01 1.000000e+00 10 99888954 99889495 542 - 0.248 0.261 0.100
ENSG00000107554 E010 23.0201700 0.0008564056 1.412231e-01 2.497157e-01 10 99894946 99895050 105 - 1.409 1.330 -0.274
ENSG00000107554 E011 20.7324832 0.0009659753 2.618884e-01 3.996196e-01 10 99896267 99896397 131 - 1.353 1.295 -0.203
ENSG00000107554 E012 27.9558287 0.0012537733 1.685031e-01 2.862201e-01 10 99898086 99898285 200 - 1.481 1.416 -0.223
ENSG00000107554 E013 9.4871194 0.0437070097 5.633935e-01 6.908762e-01 10 99898743 99898760 18 - 1.026 0.975 -0.190
ENSG00000107554 E014 27.8551168 0.0137491116 1.896779e-01 3.133516e-01 10 99899919 99900066 148 - 1.492 1.410 -0.282
ENSG00000107554 E015 28.2900887 0.0007674750 1.703514e-03 6.294137e-03 10 99907995 99908094 100 - 1.552 1.377 -0.601
ENSG00000107554 E016 36.8669247 0.0006137591 3.513075e-03 1.176388e-02 10 99908953 99909146 194 - 1.644 1.506 -0.471
ENSG00000107554 E017 1.3264085 0.2504278611 4.935761e-01 6.305737e-01 10 99913953 99914082 130 - 0.247 0.420 1.084
ENSG00000107554 E018 0.9254501 0.0132001063 1.951640e-01 3.202005e-01 10 99929608 99930996 1389 - 0.405 0.190 -1.485
ENSG00000107554 E019 141.4677216 0.0161352899 3.699488e-04 1.657969e-03 10 99955214 99957205 1992 - 2.241 2.063 -0.595
ENSG00000107554 E020 13.5328884 0.0148297698 6.609934e-02 1.368814e-01 10 99969115 99969237 123 - 1.244 1.080 -0.586
ENSG00000107554 E021 17.4981906 0.0024358349 3.318666e-05 1.952338e-04 10 99971980 99972134 155 - 1.415 1.100 -1.112
ENSG00000107554 E022 0.1482932 0.0414162162 6.934162e-01   10 100006237 100006248 12 - 0.000 0.105 8.304
ENSG00000107554 E023 9.7712566 0.0019245255 1.305394e-04 6.611673e-04 10 100009838 100009947 110 - 1.204 0.831 -1.376