ENSG00000107521

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000414009 ENSG00000107521 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS1 protein_coding protein_coding 58.38388 87.53747 37.95083 3.428905 0.1534323 -1.205554 7.295228 11.873949 3.054196 0.3668845 0.5008654 -1.9554340 0.11947500 0.13620000 0.08043333 -0.05576667 6.820547e-02 1.238568e-32 FALSE TRUE
ENST00000474873 ENSG00000107521 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS1 protein_coding processed_transcript 58.38388 87.53747 37.95083 3.428905 0.1534323 -1.205554 3.094140 1.955817 3.972955 0.2725846 0.6368456 1.0187105 0.06337500 0.02216667 0.10480000 0.08263333 1.777133e-08 1.238568e-32 FALSE TRUE
ENST00000480020 ENSG00000107521 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS1 protein_coding processed_transcript 58.38388 87.53747 37.95083 3.428905 0.1534323 -1.205554 4.621818 5.367131 3.274505 2.6884284 1.1040558 -0.7111606 0.08135833 0.05913333 0.08626667 0.02713333 8.328839e-01 1.238568e-32 FALSE TRUE
MSTRG.4473.26 ENSG00000107521 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS1 protein_coding   58.38388 87.53747 37.95083 3.428905 0.1534323 -1.205554 2.753430 1.470203 6.210983 1.4702032 0.7851059 2.0713472 0.06653333 0.01816667 0.16370000 0.14553333 4.791550e-02 1.238568e-32   FALSE
MSTRG.4473.27 ENSG00000107521 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS1 protein_coding   58.38388 87.53747 37.95083 3.428905 0.1534323 -1.205554 3.003004 4.707501 0.000000 0.2552257 0.0000000 -8.8818791 0.05165833 0.05380000 0.00000000 -0.05380000 1.238568e-32 1.238568e-32   FALSE
MSTRG.4473.5 ENSG00000107521 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS1 protein_coding   58.38388 87.53747 37.95083 3.428905 0.1534323 -1.205554 4.200814 7.934046 1.815838 0.7775939 0.3018643 -2.1213156 0.06692917 0.09140000 0.04783333 -0.04356667 6.953411e-02 1.238568e-32 FALSE TRUE
MSTRG.4473.7 ENSG00000107521 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS1 protein_coding   58.38388 87.53747 37.95083 3.428905 0.1534323 -1.205554 3.997125 6.469144 2.325929 0.2213550 0.1989959 -1.4718070 0.06457917 0.07416667 0.06126667 -0.01290000 4.869474e-01 1.238568e-32 FALSE TRUE
MSTRG.4473.8 ENSG00000107521 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS1 protein_coding   58.38388 87.53747 37.95083 3.428905 0.1534323 -1.205554 17.784971 30.442355 8.665879 2.2086756 0.2330450 -1.8114720 0.28290000 0.34700000 0.22833333 -0.11866667 2.189783e-05 1.238568e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107521 E001 3.7309031 0.0640821371 8.090225e-03 2.400803e-02 10 98415730 98415756 27 - 0.921 0.441 -2.057
ENSG00000107521 E002 33.6463151 0.0007545452 4.043722e-01 5.480829e-01 10 98416198 98416359 162 - 1.395 1.445 0.176
ENSG00000107521 E003 57.1874827 0.0005498840 4.307464e-01 5.733619e-01 10 98416360 98416483 124 - 1.635 1.669 0.115
ENSG00000107521 E004 128.7961449 0.0002566732 6.206278e-01 7.377415e-01 10 98416484 98416971 488 - 2.002 2.009 0.024
ENSG00000107521 E005 25.9897971 0.0013182256 2.816433e-01 4.215637e-01 10 98416972 98416972 1 - 1.258 1.339 0.285
ENSG00000107521 E006 39.7219144 0.0008287881 2.572770e-01 3.943521e-01 10 98416973 98417014 42 - 1.445 1.513 0.234
ENSG00000107521 E007 44.2607032 0.0044247399 6.205432e-01 7.376898e-01 10 98417015 98417037 23 - 1.531 1.557 0.088
ENSG00000107521 E008 67.6322549 0.0003647858 1.375449e-01 2.446688e-01 10 98417038 98417059 22 - 1.676 1.744 0.232
ENSG00000107521 E009 299.7386415 0.0023859096 1.979575e-07 1.898090e-06 10 98417060 98417198 139 - 2.223 2.402 0.598
ENSG00000107521 E010 492.3277243 0.0025822160 3.305281e-08 3.691203e-07 10 98417199 98417392 194 - 2.446 2.615 0.562
ENSG00000107521 E011 656.2181883 0.0014443475 2.314751e-06 1.775899e-05 10 98417393 98417726 334 - 2.622 2.730 0.360
ENSG00000107521 E012 4.9100480 0.0953544070 1.535771e-01 2.665353e-01 10 98418152 98418174 23 - 0.888 0.605 -1.151
ENSG00000107521 E013 294.0679022 0.0002093492 1.722430e-05 1.084230e-04 10 98418175 98418257 83 - 2.275 2.380 0.349
ENSG00000107521 E014 348.6409388 0.0002005086 2.950495e-02 7.097846e-02 10 98420045 98420158 114 - 2.401 2.442 0.136
ENSG00000107521 E015 1.4672393 0.1022511568 4.347902e-01 5.770785e-01 10 98420159 98420369 211 - 0.207 0.374 1.163
ENSG00000107521 E016 347.1097090 0.0006705409 7.125282e-01 8.092393e-01 10 98422369 98422513 145 - 2.452 2.431 -0.071
ENSG00000107521 E017 123.7428519 0.0032623219 3.821321e-01 5.263624e-01 10 98423603 98423607 5 - 2.033 1.980 -0.175
ENSG00000107521 E018 135.5912378 0.0058521509 9.831129e-01 9.934896e-01 10 98423608 98423616 9 - 2.040 2.028 -0.038
ENSG00000107521 E019 233.3111735 0.0012063482 4.537040e-01 5.944425e-01 10 98423617 98423668 52 - 2.253 2.266 0.043
ENSG00000107521 E020 338.1049107 0.0003016848 2.112181e-03 7.571932e-03 10 98423753 98423879 127 - 2.371 2.437 0.220
ENSG00000107521 E021 176.2980606 0.0004109369 3.678547e-03 1.223450e-02 10 98423880 98423887 8 - 2.070 2.160 0.301
ENSG00000107521 E022 234.8238956 0.0002045572 6.656926e-04 2.773127e-03 10 98424313 98424374 62 - 2.193 2.283 0.299
ENSG00000107521 E023 379.9076842 0.0001459908 9.266336e-03 2.695057e-02 10 98425541 98425720 180 - 2.435 2.482 0.159
ENSG00000107521 E024 252.5226795 0.0011985711 1.094694e-01 2.047877e-01 10 98425818 98425905 88 - 2.262 2.302 0.134
ENSG00000107521 E025 232.5855170 0.0017480595 7.098101e-01 8.070937e-01 10 98425906 98425985 80 - 2.258 2.260 0.008
ENSG00000107521 E026 5.7249117 0.0029333959 6.450621e-05 3.534595e-04 10 98425986 98426103 118 - 1.100 0.577 -2.063
ENSG00000107521 E027 197.3081858 0.0001931363 9.079902e-01 9.455898e-01 10 98427215 98427264 50 - 2.197 2.188 -0.028
ENSG00000107521 E028 0.2214452 0.0382138836 1.000000e+00   10 98429151 98429155 5 - 0.000 0.070 7.717
ENSG00000107521 E029 8.5840404 0.0020667244 4.290540e-01 5.717914e-01 10 98429156 98429299 144 - 0.813 0.909 0.372
ENSG00000107521 E030 77.3241224 0.0045785675 5.919255e-01 7.145838e-01 10 98429300 98429458 159 - 1.775 1.797 0.073
ENSG00000107521 E031 113.3222090 0.0003438464 4.073374e-03 1.334893e-02 10 98429459 98429572 114 - 1.860 1.972 0.378
ENSG00000107521 E032 321.3148997 0.0005237095 8.124226e-01 8.810271e-01 10 98429573 98429642 70 - 2.407 2.401 -0.017
ENSG00000107521 E033 102.5268161 0.0009688289 2.303682e-01 3.629047e-01 10 98429791 98429889 99 - 1.958 1.894 -0.215
ENSG00000107521 E034 345.2275032 0.0005713527 4.621587e-01 6.020418e-01 10 98430571 98430670 100 - 2.456 2.426 -0.100
ENSG00000107521 E035 317.8857610 0.0001472379 1.217458e-01 2.224189e-01 10 98431131 98431291 161 - 2.374 2.400 0.088
ENSG00000107521 E036 41.3428703 0.0100969008 6.721928e-01 7.782492e-01 10 98433940 98433982 43 - 1.562 1.516 -0.155
ENSG00000107521 E037 311.2920096 0.0002103703 9.932900e-03 2.859467e-02 10 98433983 98434091 109 - 2.342 2.396 0.181
ENSG00000107521 E038 14.6319225 0.0013003796 1.553878e-08 1.847945e-07 10 98435086 98435271 186 - 1.454 0.936 -1.847
ENSG00000107521 E039 359.5159382 0.0012411701 3.222839e-02 7.629424e-02 10 98435272 98435414 143 - 2.505 2.435 -0.233
ENSG00000107521 E040 438.2677151 0.0013182807 3.812597e-03 1.261611e-02 10 98435635 98435772 138 - 2.603 2.517 -0.286
ENSG00000107521 E041 66.4020054 0.0203140772 4.276855e-05 2.448809e-04 10 98442388 98442480 93 - 1.981 1.640 -1.148
ENSG00000107521 E042 50.6926512 0.0269110791 9.100920e-03 2.653588e-02 10 98442481 98442536 56 - 1.805 1.555 -0.848
ENSG00000107521 E043 167.7774348 0.0231326673 2.622581e-06 1.989430e-05 10 98442537 98442957 421 - 2.398 2.025 -1.247
ENSG00000107521 E044 478.5495075 0.0011969165 2.441574e-13 6.569364e-12 10 98443124 98443240 117 - 2.718 2.531 -0.622
ENSG00000107521 E045 360.9575336 0.0034247606 7.890390e-05 4.227526e-04 10 98445300 98445404 105 - 2.566 2.420 -0.489
ENSG00000107521 E046 156.8547250 0.0011112464 2.925339e-02 7.049683e-02 10 98445405 98445413 9 - 2.163 2.072 -0.306
ENSG00000107521 E047 18.8018410 0.0054992000 7.448470e-03 2.238176e-02 10 98446647 98446806 160 - 1.384 1.126 -0.907
ENSG00000107521 E048 197.0216586 0.0014656324 9.026942e-05 4.762922e-04 10 98446807 98446886 80 - 2.302 2.158 -0.483
ENSG00000107521 E049 108.8874554 0.0027301092 2.358700e-02 5.896191e-02 10 98446887 98448014 1128 - 2.028 1.911 -0.392