ENSG00000107404

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378888 ENSG00000107404 HEK293_OSMI2_2hA HEK293_TMG_2hB DVL1 protein_coding protein_coding 65.53731 98.73073 38.98486 9.594925 0.8666142 -1.340361 26.098893 41.70239 13.074073 3.888479 1.2178057 -1.6726643 0.3896292 0.4228333 0.3343333 -0.0885 0.06631155 1.439697e-06 FALSE  
ENST00000378891 ENSG00000107404 HEK293_OSMI2_2hA HEK293_TMG_2hB DVL1 protein_coding protein_coding 65.53731 98.73073 38.98486 9.594925 0.8666142 -1.340361 24.208273 38.76607 15.299297 3.072470 0.5880313 -1.3407586 0.3590250 0.3940000 0.3933000 -0.0007 1.00000000 1.439697e-06 FALSE  
ENST00000631679 ENSG00000107404 HEK293_OSMI2_2hA HEK293_TMG_2hB DVL1 protein_coding protein_coding 65.53731 98.73073 38.98486 9.594925 0.8666142 -1.340361 9.353552 12.39839 6.858287 1.545031 0.4829486 -0.8532937 0.1510542 0.1249000 0.1760000 0.0511 0.02826992 1.439697e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107404 E001 0.000000       1 1335276 1335277 2 -      
ENSG00000107404 E002 2062.672001 0.0021476988 2.120010e-09 2.955332e-08 1 1335278 1336411 1134 - 3.115 3.263 0.493
ENSG00000107404 E003 451.119482 0.0017299010 3.783826e-04 1.691086e-03 1 1336412 1336515 104 - 2.474 2.596 0.406
ENSG00000107404 E004 6.071359 0.0033584210 1.681335e-01 2.857654e-01 1 1337018 1337022 5 - 0.576 0.804 0.959
ENSG00000107404 E005 6.816149 0.0025941351 5.601460e-01 6.881662e-01 1 1337023 1337055 33 - 0.734 0.830 0.380
ENSG00000107404 E006 795.652916 0.0016029808 3.227308e-03 1.093648e-02 1 1337977 1338183 207 - 2.747 2.838 0.302
ENSG00000107404 E007 543.003822 0.0010011151 4.593479e-02 1.019164e-01 1 1338269 1338333 65 - 2.602 2.666 0.214
ENSG00000107404 E008 611.982432 0.0001090938 5.966833e-01 7.185894e-01 1 1338334 1338436 103 - 2.683 2.707 0.079
ENSG00000107404 E009 678.767544 0.0002404889 7.253563e-01 8.186575e-01 1 1338522 1338653 132 - 2.729 2.751 0.072
ENSG00000107404 E010 234.244140 0.0001817499 9.709173e-03 2.804522e-02 1 1339287 1339361 75 - 2.215 2.303 0.295
ENSG00000107404 E011 518.226978 0.0001643553 2.256043e-01 3.571211e-01 1 1339362 1339439 78 - 2.634 2.626 -0.025
ENSG00000107404 E012 20.361544 0.0009392011 4.431885e-05 2.529014e-04 1 1339440 1339491 52 - 1.465 1.153 -1.092
ENSG00000107404 E013 10.170787 0.0017135896 3.349714e-03 1.129049e-02 1 1339492 1339581 90 - 1.187 0.887 -1.100
ENSG00000107404 E014 439.258510 0.0001488550 9.392837e-02 1.812708e-01 1 1339582 1339649 68 - 2.518 2.568 0.165
ENSG00000107404 E015 10.565326 0.0135396997 2.612822e-01 3.989188e-01 1 1339650 1339735 86 - 1.081 0.957 -0.456
ENSG00000107404 E016 474.158837 0.0001316817 2.506949e-01 3.867617e-01 1 1339736 1339812 77 - 2.596 2.589 -0.025
ENSG00000107404 E017 581.727918 0.0001441010 2.303609e-05 1.407916e-04 1 1340038 1340177 140 - 2.724 2.666 -0.194
ENSG00000107404 E018 4.320022 0.0038359047 1.074063e-01 2.017169e-01 1 1340178 1340190 13 - 0.815 0.588 -0.943
ENSG00000107404 E019 434.170565 0.0002794550 1.511482e-05 9.640838e-05 1 1340247 1340316 70 - 2.610 2.536 -0.245
ENSG00000107404 E020 1.042508 0.1074345956 6.729520e-01 7.787568e-01 1 1340317 1340365 49 - 0.324 0.248 -0.528
ENSG00000107404 E021 421.565395 0.0022157300 3.932478e-03 1.295285e-02 1 1340410 1340503 94 - 2.596 2.528 -0.226
ENSG00000107404 E022 445.500811 0.0028751716 8.563285e-02 1.684042e-01 1 1341667 1341769 103 - 2.594 2.559 -0.115
ENSG00000107404 E023 334.719192 0.0021392044 2.447467e-01 3.797516e-01 1 1341770 1341805 36 - 2.454 2.438 -0.056
ENSG00000107404 E024 36.919872 0.0025567964 8.781417e-05 4.647873e-04 1 1341806 1342052 247 - 1.666 1.425 -0.826
ENSG00000107404 E025 498.221396 0.0016421854 3.212192e-03 1.089168e-02 1 1342053 1342156 104 - 2.657 2.601 -0.189
ENSG00000107404 E026 506.111416 0.0010217388 1.149008e-02 3.232809e-02 1 1342363 1342484 122 - 2.650 2.611 -0.133
ENSG00000107404 E027 411.182906 0.0017167797 3.872839e-04 1.725779e-03 1 1342689 1342758 70 - 2.589 2.512 -0.259
ENSG00000107404 E028 410.615950 0.0015233896 3.593944e-12 8.046384e-11 1 1348896 1349418 523 - 2.652 2.487 -0.547