ENSG00000107362

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333421 ENSG00000107362 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD17B protein_coding protein_coding 9.626619 3.813139 15.77046 0.6742833 0.2764098 2.04531 6.9516791 3.79056197 11.07199 0.67619705 0.6016949 1.543932 0.82335417 0.993933333 0.70276667 -0.29116667 2.347195e-10 6.908594e-12 FALSE TRUE
ENST00000377041 ENSG00000107362 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD17B protein_coding protein_coding 9.626619 3.813139 15.77046 0.6742833 0.2764098 2.04531 0.5836488 0.02257694 1.29026 0.02257694 0.6111349 5.318805 0.04963333 0.006066667 0.08233333 0.07626667 6.066166e-02 6.908594e-12 FALSE TRUE
MSTRG.32855.3 ENSG00000107362 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD17B protein_coding   9.626619 3.813139 15.77046 0.6742833 0.2764098 2.04531 2.0854580 0.00000000 3.40821 0.00000000 0.5964045 8.417097 0.12483750 0.000000000 0.21493333 0.21493333 6.908594e-12 6.908594e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107362 E001 2.435832 0.0061102026 2.098881e-01 3.384110e-01 9 71862452 71862607 156 - 0.549 0.336 -1.120
ENSG00000107362 E002 288.406418 0.0030798935 1.995341e-14 6.280300e-13 9 71865152 71866668 1517 - 2.340 2.569 0.766
ENSG00000107362 E003 55.339440 0.0008648567 1.658041e-01 2.827501e-01 9 71866669 71866798 130 - 1.713 1.673 -0.133
ENSG00000107362 E004 41.600315 0.0017844424 2.279259e-01 3.599573e-01 9 71866799 71866814 16 - 1.592 1.550 -0.144
ENSG00000107362 E005 101.611240 0.0003033280 8.778945e-02 1.717752e-01 9 71866815 71867006 192 - 1.972 1.944 -0.094
ENSG00000107362 E006 88.785170 0.0004591061 2.141051e-01 3.433638e-01 9 71870083 71870262 180 - 1.912 1.899 -0.046
ENSG00000107362 E007 53.540891 0.0005169976 8.294514e-01 8.929156e-01 9 71874614 71874682 69 - 1.676 1.724 0.163
ENSG00000107362 E008 122.486584 0.0040145283 8.480023e-03 2.498623e-02 9 71874683 71875083 401 - 2.064 1.977 -0.290
ENSG00000107362 E009 1.044700 0.1293425305 5.365161e-01 6.682668e-01 9 71906693 71906758 66 - 0.320 0.199 -0.911
ENSG00000107362 E010 112.278673 0.0003451587 2.389859e-15 8.604173e-14 9 71910634 71911193 560 - 2.066 1.782 -0.956