ENSG00000107290

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000224140 ENSG00000107290 HEK293_OSMI2_2hA HEK293_TMG_2hB SETX protein_coding protein_coding 6.514312 2.769291 9.15279 0.2041271 0.1463245 1.72107 2.8641611 0.4559368 5.02952821 0.1164987 0.16305123 3.4350825 0.3628083 0.1725333 0.549933333 0.3774000 3.069123e-04 7.568074e-08 FALSE TRUE
ENST00000436441 ENSG00000107290 HEK293_OSMI2_2hA HEK293_TMG_2hB SETX protein_coding protein_coding 6.514312 2.769291 9.15279 0.2041271 0.1463245 1.72107 1.2859343 0.8313221 1.57649878 0.1332343 0.14153483 0.9151163 0.2350167 0.3097667 0.172000000 -0.1377667 2.258289e-01 7.568074e-08 FALSE TRUE
ENST00000477049 ENSG00000107290 HEK293_OSMI2_2hA HEK293_TMG_2hB SETX protein_coding processed_transcript 6.514312 2.769291 9.15279 0.2041271 0.1463245 1.72107 0.7558833 1.4122591 0.05046554 0.4932529 0.05046554 -4.5559272 0.2169917 0.4895000 0.005366667 -0.4841333 8.689503e-05 7.568074e-08 FALSE TRUE
MSTRG.33553.5 ENSG00000107290 HEK293_OSMI2_2hA HEK293_TMG_2hB SETX protein_coding   6.514312 2.769291 9.15279 0.2041271 0.1463245 1.72107 0.9780801 0.0000000 1.64497505 0.0000000 0.31936784 7.3706657 0.1001500 0.0000000 0.179400000 0.1794000 7.568074e-08 7.568074e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107290 E001 321.8085726 0.0267128878 8.974699e-12 1.884120e-10 9 132261356 132263956 2601 - 2.228 2.775 1.822
ENSG00000107290 E002 118.4825190 0.0058870201 5.886444e-06 4.124783e-05 9 132263957 132264570 614 - 1.875 2.200 1.088
ENSG00000107290 E003 30.0150335 0.0006501971 9.509505e-04 3.791055e-03 9 132264571 132264587 17 - 1.289 1.621 1.144
ENSG00000107290 E004 53.2591028 0.0004720806 9.426921e-03 2.734835e-02 9 132264588 132264730 143 - 1.557 1.799 0.821
ENSG00000107290 E005 62.5671234 0.0230039124 7.756224e-01 8.554573e-01 9 132264731 132264985 255 - 1.652 1.778 0.427
ENSG00000107290 E006 2.0712882 0.0067339827 2.108309e-01 3.395385e-01 9 132266127 132266249 123 - 0.336 0.630 1.480
ENSG00000107290 E007 13.4064052 0.0013350109 4.379749e-01 5.798533e-01 9 132269403 132269489 87 - 0.998 1.172 0.630
ENSG00000107290 E008 41.0446221 0.0017707913 3.475669e-01 4.917845e-01 9 132269615 132269702 88 - 1.463 1.621 0.540
ENSG00000107290 E009 44.7661605 0.0005202249 8.495570e-01 9.066453e-01 9 132271710 132271808 99 - 1.514 1.595 0.274
ENSG00000107290 E010 2.1391573 0.0065382550 8.164755e-01 8.838841e-01 9 132274923 132275255 333 - 0.408 0.420 0.065
ENSG00000107290 E011 51.2847733 0.0004860253 5.751280e-01 7.008362e-01 9 132275256 132275420 165 - 1.563 1.691 0.435
ENSG00000107290 E012 29.3556668 0.0317921996 9.084835e-01 9.458648e-01 9 132277060 132277152 93 - 1.336 1.413 0.267
ENSG00000107290 E013 38.7881773 0.0005820661 3.232256e-01 4.665421e-01 9 132278070 132278257 188 - 1.463 1.482 0.066
ENSG00000107290 E014 27.3427820 0.0007083862 1.790080e-01 2.998906e-01 9 132281467 132281574 108 - 1.325 1.296 -0.102
ENSG00000107290 E015 0.7363589 0.0155700637 4.049709e-01 5.486464e-01 9 132282770 132282792 23 - 0.217 0.000 -11.377
ENSG00000107290 E016 0.7342825 0.0168224216 4.056291e-01 5.492966e-01 9 132282793 132282857 65 - 0.217 0.000 -11.377
ENSG00000107290 E017 0.5827671 0.1438516795 5.994116e-01 7.208075e-01 9 132282858 132282874 17 - 0.181 0.000 -11.053
ENSG00000107290 E018 1.0287806 0.0121782609 2.364658e-01 3.700732e-01 9 132282875 132282902 28 - 0.281 0.000 -11.863
ENSG00000107290 E019 1.4684513 0.0339769946 1.227268e-01 2.238484e-01 9 132282903 132283263 361 - 0.361 0.000 -12.377
ENSG00000107290 E020 34.1137831 0.0051878738 5.103683e-01 6.455963e-01 9 132283264 132283413 150 - 1.410 1.446 0.127
ENSG00000107290 E021 22.4657592 0.0009697677 3.075420e-01 4.497770e-01 9 132286423 132286494 72 - 1.246 1.238 -0.028
ENSG00000107290 E022 0.0000000       9 132286495 132286497 3 -      
ENSG00000107290 E023 30.0609019 0.0010022384 6.363259e-01 7.503566e-01 9 132288236 132288351 116 - 1.353 1.406 0.183
ENSG00000107290 E024 30.8443590 0.0025389542 1.594949e-02 4.261814e-02 9 132288550 132288651 102 - 1.389 1.259 -0.455
ENSG00000107290 E025 38.4422376 0.0006746147 4.156330e-01 5.590017e-01 9 132295872 132296028 157 - 1.461 1.494 0.111
ENSG00000107290 E026 43.5849593 0.0007572161 2.242863e-02 5.656934e-02 9 132296887 132297054 168 - 1.533 1.458 -0.257
ENSG00000107290 E027 46.2168630 0.0006655311 7.134349e-02 1.455645e-01 9 132298080 132298274 195 - 1.549 1.516 -0.114
ENSG00000107290 E028 19.2955424 0.0087048453 2.576417e-01 3.948026e-01 9 132298275 132298312 38 - 1.188 1.148 -0.143
ENSG00000107290 E029 32.0695291 0.0008188620 9.270892e-02 1.793596e-01 9 132300630 132300803 174 - 1.396 1.346 -0.173
ENSG00000107290 E030 25.5891392 0.0032018755 5.129798e-03 1.628175e-02 9 132311757 132311856 100 - 1.322 1.122 -0.708
ENSG00000107290 E031 83.8151442 0.0005956434 1.910143e-05 1.190365e-04 9 132326324 132326952 629 - 1.815 1.669 -0.493
ENSG00000107290 E032 310.2952098 0.0135993131 6.761283e-13 1.706053e-11 9 132326953 132330499 3547 - 2.400 2.061 -1.134
ENSG00000107290 E033 22.7883242 0.0051608787 3.483501e-03 1.167723e-02 9 132331052 132331139 88 - 1.277 1.033 -0.872
ENSG00000107290 E034 33.0484342 0.0047959375 1.607585e-04 7.953413e-04 9 132331277 132331448 172 - 1.435 1.148 -1.006
ENSG00000107290 E035 28.2206696 0.0052112245 3.939071e-09 5.230568e-08 9 132334608 132334727 120 - 1.396 0.706 -2.552
ENSG00000107290 E036 36.5046503 0.0006586020 3.472416e-11 6.614104e-10 9 132336296 132336515 220 - 1.502 0.876 -2.239
ENSG00000107290 E037 22.6973606 0.0045222816 7.511027e-10 1.140708e-08 9 132342690 132342799 110 - 1.314 0.420 -3.588
ENSG00000107290 E038 30.3262644 0.0026627781 7.695105e-09 9.687763e-08 9 132346261 132346471 211 - 1.423 0.827 -2.157
ENSG00000107290 E039 28.7043792 0.0198674029 2.103846e-04 1.008342e-03 9 132349252 132349435 184 - 1.388 0.999 -1.381
ENSG00000107290 E040 19.8938060 0.1204687339 1.548168e-02 4.158867e-02 9 132353649 132353755 107 - 1.240 0.827 -1.519
ENSG00000107290 E041 11.3453664 0.0453250711 1.345279e-02 3.697145e-02 9 132354917 132355027 111 - 1.015 0.629 -1.521