ENSG00000107263

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372190 ENSG00000107263 HEK293_OSMI2_2hA HEK293_TMG_2hB RAPGEF1 protein_coding protein_coding 20.79316 29.90034 15.89189 2.384773 0.2967584 -0.9114463 9.6948845 17.7043086 4.494270 0.98617991 0.9826923 -1.9755498 0.43093750 0.594733333 0.28530000 -0.3094333 0.0037584784 0.0001096092 FALSE TRUE
ENST00000372195 ENSG00000107263 HEK293_OSMI2_2hA HEK293_TMG_2hB RAPGEF1 protein_coding protein_coding 20.79316 29.90034 15.89189 2.384773 0.2967584 -0.9114463 1.8279147 1.8586277 2.638405 0.57250140 0.6614440 0.5031449 0.10049583 0.061366667 0.16533333 0.1039667 0.0591874536 0.0001096092 FALSE TRUE
MSTRG.33545.5 ENSG00000107263 HEK293_OSMI2_2hA HEK293_TMG_2hB RAPGEF1 protein_coding   20.79316 29.90034 15.89189 2.384773 0.2967584 -0.9114463 7.7835183 8.4426991 7.169725 1.40876203 0.6169235 -0.2354835 0.39065000 0.278100000 0.45006667 0.1719667 0.0120024792 0.0001096092 FALSE TRUE
MSTRG.33545.6 ENSG00000107263 HEK293_OSMI2_2hA HEK293_TMG_2hB RAPGEF1 protein_coding   20.79316 29.90034 15.89189 2.384773 0.2967584 -0.9114463 0.5487999 0.2114968 1.308832 0.05505513 0.4199269 2.5739033 0.03285417 0.006866667 0.08146667 0.0746000 0.0001096092 0.0001096092 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107263 E001 0.6997360 0.0172671820 1.451467e-01 2.550373e-01 9 131576770 131576774 5 - 0.000 0.296 17.983
ENSG00000107263 E002 2.7614697 0.0057716329 4.642379e-01 6.039952e-01 9 131576775 131576777 3 - 0.436 0.595 0.762
ENSG00000107263 E003 128.4539940 0.0146518571 1.295969e-04 6.570261e-04 9 131576778 131576988 211 - 1.841 2.160 1.069
ENSG00000107263 E004 1872.5770001 0.0078097643 1.873541e-09 2.638739e-08 9 131576989 131579218 2230 - 3.048 3.309 0.867
ENSG00000107263 E005 170.7604757 0.0002241824 5.746514e-01 7.004406e-01 9 131579219 131579299 81 - 2.154 2.220 0.222
ENSG00000107263 E006 360.2674940 0.0007375102 3.889870e-01 5.330644e-01 9 131579300 131579647 348 - 2.475 2.546 0.237
ENSG00000107263 E007 236.1153904 0.0001637219 6.674143e-01 7.746483e-01 9 131580263 131580391 129 - 2.297 2.358 0.202
ENSG00000107263 E008 213.5135334 0.0001918864 9.416556e-01 9.673342e-01 9 131582605 131582702 98 - 2.262 2.310 0.160
ENSG00000107263 E009 208.2430088 0.0011888545 9.195271e-01 9.531664e-01 9 131584311 131584412 102 - 2.248 2.303 0.183
ENSG00000107263 E010 160.9733898 0.0030325515 1.292232e-01 2.331031e-01 9 131584518 131584596 79 - 2.093 2.208 0.385
ENSG00000107263 E011 125.6189926 0.0002775196 4.361297e-01 5.782555e-01 9 131587736 131587830 95 - 2.012 2.088 0.256
ENSG00000107263 E012 136.2070953 0.0004141906 3.466037e-01 4.907221e-01 9 131587942 131588026 85 - 2.042 2.124 0.274
ENSG00000107263 E013 110.6912427 0.0003091108 5.799413e-02 1.231927e-01 9 131588801 131588848 48 - 1.925 2.045 0.404
ENSG00000107263 E014 190.7694559 0.0002032250 8.900317e-01 9.337297e-01 9 131588849 131588986 138 - 2.216 2.262 0.153
ENSG00000107263 E015 174.6164370 0.0002189973 4.727841e-01 6.118335e-01 9 131589886 131589978 93 - 2.189 2.218 0.097
ENSG00000107263 E016 178.6111369 0.0002854142 1.976576e-02 5.099014e-02 9 131592099 131592183 85 - 2.231 2.214 -0.055
ENSG00000107263 E017 176.2608817 0.0034715110 5.061691e-03 1.609876e-02 9 131596298 131596373 76 - 2.256 2.198 -0.193
ENSG00000107263 E018 184.0380920 0.0005677660 6.589351e-03 2.015846e-02 9 131598199 131598310 112 - 2.253 2.224 -0.096
ENSG00000107263 E019 123.2890479 0.0052109509 6.414583e-02 1.336052e-01 9 131602061 131602113 53 - 2.084 2.051 -0.110
ENSG00000107263 E020 104.3273904 0.0043531196 8.506037e-02 1.675010e-01 9 131602114 131602149 36 - 2.008 1.980 -0.094
ENSG00000107263 E021 1.1489717 0.0115259387 2.069814e-01 3.349141e-01 9 131603961 131604053 93 - 0.436 0.239 -1.238
ENSG00000107263 E022 1.9960704 0.0081842177 5.623608e-01 6.899878e-01 9 131604931 131605188 258 - 0.500 0.433 -0.338
ENSG00000107263 E023 3.9125057 0.0965862266 5.170323e-01 6.515160e-01 9 131619051 131619206 156 - 0.727 0.625 -0.428
ENSG00000107263 E024 0.5202097 0.0207574401 2.474842e-01 3.829883e-01 9 131619207 131619209 3 - 0.271 0.095 -1.821
ENSG00000107263 E025 190.3785740 0.0044378157 5.479576e-02 1.176452e-01 9 131621796 131621998 203 - 2.266 2.241 -0.083
ENSG00000107263 E026 178.1757453 0.0030893611 6.461866e-03 1.982481e-02 9 131625922 131626159 238 - 2.252 2.202 -0.169
ENSG00000107263 E027 227.5701187 0.0001687189 8.014557e-11 1.437680e-09 9 131626160 131626422 263 - 2.395 2.286 -0.364
ENSG00000107263 E028 190.9083892 0.0040206718 1.039857e-04 5.404308e-04 9 131627913 131628096 184 - 2.313 2.213 -0.335
ENSG00000107263 E029 136.6138242 0.0152685797 1.608896e-02 4.293629e-02 9 131628549 131628672 124 - 2.174 2.069 -0.352
ENSG00000107263 E030 158.2079820 0.0067430189 3.010486e-05 1.790892e-04 9 131629102 131629254 153 - 2.263 2.115 -0.495
ENSG00000107263 E031 129.9831771 0.0036319018 2.492179e-05 1.511802e-04 9 131630236 131630324 89 - 2.166 2.038 -0.428
ENSG00000107263 E032 124.6746775 0.0002778902 4.908789e-06 3.500547e-05 9 131638635 131638697 63 - 2.129 2.028 -0.341
ENSG00000107263 E033 142.8062501 0.0003099482 2.073176e-07 1.981519e-06 9 131638698 131638791 94 - 2.194 2.082 -0.375
ENSG00000107263 E034 184.5944241 0.0017602531 8.942648e-08 9.159591e-07 9 131643239 131643417 179 - 2.314 2.190 -0.415
ENSG00000107263 E035 30.3277564 0.0157379355 4.217524e-02 9.504744e-02 9 131650129 131650144 16 - 1.547 1.423 -0.426
ENSG00000107263 E036 46.9587516 0.0188008421 3.238284e-02 7.659350e-02 9 131650145 131650242 98 - 1.727 1.609 -0.401
ENSG00000107263 E037 111.0628336 0.0141511270 1.043548e-05 6.908807e-05 9 131650810 131650949 140 - 2.164 1.926 -0.796
ENSG00000107263 E038 0.0000000       9 131709620 131709721 102 -      
ENSG00000107263 E039 0.0000000       9 131737405 131737538 134 -      
ENSG00000107263 E040 42.2144612 0.0207067795 2.938284e-06 2.203155e-05 9 131739770 131740076 307 - 1.812 1.451 -1.231