ENSG00000107140

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336395 ENSG00000107140 HEK293_OSMI2_2hA HEK293_TMG_2hB TESK1 protein_coding protein_coding 24.39533 34.37971 20.33065 2.153242 0.1622053 -0.7576113 5.752398 5.170152 9.102963 1.4992115 0.8046053 0.8149257 0.2235417 0.14710000 0.4475000 0.30040000 2.367426e-03 2.416631e-32 FALSE TRUE
ENST00000463897 ENSG00000107140 HEK293_OSMI2_2hA HEK293_TMG_2hB TESK1 protein_coding processed_transcript 24.39533 34.37971 20.33065 2.153242 0.1622053 -0.7576113 2.638309 2.214458 2.588861 0.1532776 0.1512413 0.2244256 0.1151208 0.06466667 0.1274000 0.06273333 2.945078e-04 2.416631e-32   FALSE
ENST00000467424 ENSG00000107140 HEK293_OSMI2_2hA HEK293_TMG_2hB TESK1 protein_coding processed_transcript 24.39533 34.37971 20.33065 2.153242 0.1622053 -0.7576113 3.280627 2.727351 3.415349 0.3129164 0.2101847 0.3234705 0.1443500 0.07880000 0.1679000 0.08910000 8.744755e-07 2.416631e-32 FALSE FALSE
ENST00000480077 ENSG00000107140 HEK293_OSMI2_2hA HEK293_TMG_2hB TESK1 protein_coding processed_transcript 24.39533 34.37971 20.33065 2.153242 0.1622053 -0.7576113 1.231319 0.396401 1.393428 0.1720149 0.1851578 1.7879796 0.0577875 0.01096667 0.0684000 0.05743333 8.795266e-04 2.416631e-32 FALSE TRUE
ENST00000498522 ENSG00000107140 HEK293_OSMI2_2hA HEK293_TMG_2hB TESK1 protein_coding processed_transcript 24.39533 34.37971 20.33065 2.153242 0.1622053 -0.7576113 4.208351 6.644245 3.658016 1.4187177 1.0008746 -0.8592752 0.1686250 0.19133333 0.1802333 -0.01110000 9.323219e-01 2.416631e-32 FALSE TRUE
ENST00000620767 ENSG00000107140 HEK293_OSMI2_2hA HEK293_TMG_2hB TESK1 protein_coding protein_coding 24.39533 34.37971 20.33065 2.153242 0.1622053 -0.7576113 6.665419 15.926068 0.000000 0.8599822 0.0000000 -10.6380800 0.2683833 0.47000000 0.0000000 -0.47000000 2.416631e-32 2.416631e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107140 E001 0.2987644 0.0290785164 6.165479e-02   9 35605262 35605304 43 + 0.291 0.000 -11.075
ENSG00000107140 E002 15.3453975 0.0164934613 5.570249e-09 7.209585e-08 9 35605305 35605425 121 + 1.499 0.900 -2.137
ENSG00000107140 E003 17.4124404 0.0157941059 3.736639e-07 3.389328e-06 9 35605426 35605473 48 + 1.505 1.009 -1.753
ENSG00000107140 E004 15.8050322 0.0039574958 1.386948e-06 1.116815e-05 9 35605474 35605490 17 + 1.428 1.005 -1.499
ENSG00000107140 E005 100.5442987 0.0093971108 2.500911e-02 6.189209e-02 9 35605491 35605838 348 + 2.038 1.917 -0.404
ENSG00000107140 E006 151.3801917 0.0035811321 1.832527e-01 3.052821e-01 9 35605984 35606105 122 + 2.165 2.118 -0.156
ENSG00000107140 E007 115.8073108 0.0022884629 9.551551e-01 9.758567e-01 9 35606237 35606285 49 + 2.016 2.020 0.015
ENSG00000107140 E008 185.4185294 0.0007984122 9.515225e-01 9.736740e-01 9 35606837 35606971 135 + 2.217 2.221 0.015
ENSG00000107140 E009 99.5155365 0.0014859449 3.641946e-01 5.085599e-01 9 35606972 35606983 12 + 1.976 1.945 -0.105
ENSG00000107140 E010 36.5009211 0.0006022247 5.548034e-16 2.168472e-14 9 35606984 35607224 241 + 1.803 1.344 -1.570
ENSG00000107140 E011 30.0452288 0.0015783576 5.247570e-08 5.632820e-07 9 35607225 35607326 102 + 1.662 1.313 -1.200
ENSG00000107140 E012 155.5889602 0.0015728981 3.877829e-01 5.319274e-01 9 35607327 35607409 83 + 2.162 2.138 -0.079
ENSG00000107140 E013 24.5346816 0.0019484702 5.113949e-07 4.514970e-06 9 35607410 35607581 172 + 1.583 1.230 -1.222
ENSG00000107140 E014 178.9068845 0.0002482065 8.086767e-01 8.784784e-01 9 35607582 35607665 84 + 2.195 2.208 0.044
ENSG00000107140 E015 103.6333439 0.0003232475 5.452073e-01 6.755965e-01 9 35607666 35607672 7 + 1.944 1.973 0.098
ENSG00000107140 E016 8.2773101 0.0037029524 2.185212e-06 1.684976e-05 9 35607673 35607927 255 + 1.224 0.699 -1.979
ENSG00000107140 E017 187.5987995 0.0003571061 2.387927e-01 3.727450e-01 9 35607928 35608011 84 + 2.241 2.214 -0.091
ENSG00000107140 E018 199.0409938 0.0040381933 8.227708e-01 8.882526e-01 9 35608160 35608249 90 + 2.250 2.250 -0.001
ENSG00000107140 E019 2.2433495 0.0069480099 1.885837e-01 3.119532e-01 9 35608250 35608282 33 + 0.291 0.536 1.353
ENSG00000107140 E020 248.0875177 0.0005591900 9.938129e-02 1.895435e-01 9 35608395 35608509 115 + 2.309 2.358 0.167
ENSG00000107140 E021 344.3391453 0.0014611487 3.060953e-02 7.316465e-02 9 35608862 35609106 245 + 2.441 2.506 0.216
ENSG00000107140 E022 723.4256813 0.0009693582 5.512252e-13 1.408904e-11 9 35609107 35610041 935 + 2.707 2.844 0.458