ENSG00000107130

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372398 ENSG00000107130 HEK293_OSMI2_2hA HEK293_TMG_2hB NCS1 protein_coding protein_coding 23.41904 39.34597 17.90056 2.807338 0.7583211 -1.135772 18.2743669 34.2292668 11.847809 1.7104102 0.3007506 -1.529814 0.74306667 0.873333333 0.6634333 -0.2099000 0.0007479314 0.0007090401 FALSE TRUE
ENST00000630865 ENSG00000107130 HEK293_OSMI2_2hA HEK293_TMG_2hB NCS1 protein_coding protein_coding 23.41904 39.34597 17.90056 2.807338 0.7583211 -1.135772 3.1551185 3.5059457 2.285491 1.3139647 1.1869125 -0.615110 0.16144167 0.086033333 0.1229333 0.0369000 1.0000000000 0.0007090401 FALSE TRUE
MSTRG.33514.1 ENSG00000107130 HEK293_OSMI2_2hA HEK293_TMG_2hB NCS1 protein_coding   23.41904 39.34597 17.90056 2.807338 0.7583211 -1.135772 0.8276246 0.2388692 1.973457 0.2388692 0.3115105 2.994558 0.03967917 0.005533333 0.1118667 0.1063333 0.0125224525 0.0007090401 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107130 E001 1.5135158 0.0088206801 2.476869e-05 1.504008e-04 9 130172344 130172402 59 + 0.765 0.078 -4.604
ENSG00000107130 E002 1.5135158 0.0088206801 2.476869e-05 1.504008e-04 9 130172403 130172403 1 + 0.765 0.078 -4.604
ENSG00000107130 E003 1.5135158 0.0088206801 2.476869e-05 1.504008e-04 9 130172404 130172408 5 + 0.765 0.078 -4.604
ENSG00000107130 E004 2.7646720 0.0165272017 1.147024e-06 9.404901e-06 9 130172409 130172428 20 + 0.955 0.203 -3.755
ENSG00000107130 E005 120.2341330 0.0002646200 2.384278e-04 1.126701e-03 9 130172429 130172727 299 + 2.092 1.980 -0.375
ENSG00000107130 E006 0.0000000       9 130193828 130193945 118 +      
ENSG00000107130 E007 0.0000000       9 130200432 130200611 180 +      
ENSG00000107130 E008 132.0269890 0.0002460055 6.884208e-01 7.905599e-01 9 130200958 130200982 25 + 2.044 2.049 0.016
ENSG00000107130 E009 290.7670496 0.0002388540 6.808313e-01 7.846732e-01 9 130217832 130217970 139 + 2.382 2.392 0.032
ENSG00000107130 E010 300.3329665 0.0021507047 1.183470e-01 2.175690e-01 9 130219725 130219803 79 + 2.427 2.399 -0.094
ENSG00000107130 E011 334.2666384 0.0002413601 1.516544e-04 7.543974e-04 9 130222650 130222738 89 + 2.500 2.436 -0.213
ENSG00000107130 E012 305.3388931 0.0001642938 1.071093e-02 3.047876e-02 9 130223082 130223159 78 + 2.441 2.402 -0.131
ENSG00000107130 E013 337.9471538 0.0001626232 2.091575e-01 3.375208e-01 9 130226389 130226504 116 + 2.461 2.453 -0.028
ENSG00000107130 E014 1375.1323415 0.0003770450 2.951601e-02 7.100056e-02 9 130232990 130234437 1448 + 3.067 3.063 -0.013
ENSG00000107130 E015 1948.4928083 0.0012152967 1.637494e-08 1.940199e-07 9 130234438 130237303 2866 + 3.139 3.238 0.332
ENSG00000107130 E016 0.9179615 0.0168534709 2.190943e-01 3.492865e-01 9 130237360 130237394 35 + 0.416 0.202 -1.437