ENSG00000107105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000223951 ENSG00000107105 HEK293_OSMI2_2hA HEK293_TMG_2hB ELAVL2 protein_coding protein_coding 3.811767 0.7915306 6.644349 0.06474446 0.08474113 3.053468 1.1340105 0.54255745 1.5325208 0.07112320 0.19894489 1.481094 0.4505375 0.6815000 0.2307000 -0.45080000 1.059601e-05 7.052804e-10 FALSE TRUE
ENST00000544538 ENSG00000107105 HEK293_OSMI2_2hA HEK293_TMG_2hB ELAVL2 protein_coding protein_coding 3.811767 0.7915306 6.644349 0.06474446 0.08474113 3.053468 0.6013576 0.19694366 1.5772510 0.01791944 0.27567345 2.939220 0.1917292 0.2499333 0.2368667 -0.01306667 9.363915e-01 7.052804e-10 FALSE TRUE
MSTRG.32481.6 ENSG00000107105 HEK293_OSMI2_2hA HEK293_TMG_2hB ELAVL2 protein_coding   3.811767 0.7915306 6.644349 0.06474446 0.08474113 3.053468 1.3212825 0.00000000 2.3557972 0.00000000 0.08817817 7.886183 0.2104208 0.0000000 0.3550333 0.35503333 7.052804e-10 7.052804e-10 FALSE TRUE
MSTRG.32481.7 ENSG00000107105 HEK293_OSMI2_2hA HEK293_TMG_2hB ELAVL2 protein_coding   3.811767 0.7915306 6.644349 0.06474446 0.08474113 3.053468 0.5325042 0.02818001 0.9748522 0.02818001 0.16530553 4.689018 0.1069667 0.0419000 0.1463667 0.10446667 1.457597e-01 7.052804e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000107105 E001 0.2987644 0.0273781524 1.000000e+00   9 23690104 23690106 3 - 0.102 0.000 -8.249
ENSG00000107105 E002 99.6676299 0.0003298892 1.526890e-19 9.271307e-18 9 23690107 23691810 1704 - 1.806 2.121 1.057
ENSG00000107105 E003 44.0729608 0.0026986782 5.674533e-01 6.942442e-01 9 23691811 23692488 678 - 1.521 1.559 0.130
ENSG00000107105 E004 13.7995465 0.0013940842 3.607185e-01 5.050704e-01 9 23692489 23692536 48 - 1.069 0.954 -0.423
ENSG00000107105 E005 42.2412813 0.0007653201 1.057573e-01 1.992482e-01 9 23692537 23692884 348 - 1.531 1.411 -0.411
ENSG00000107105 E006 2.4077328 0.0063237859 3.193325e-01 4.624061e-01 9 23692885 23692887 3 - 0.475 0.255 -1.312
ENSG00000107105 E007 0.8815316 0.0134953967 4.090794e-01 5.526908e-01 9 23693448 23693486 39 - 0.254 0.000 -11.395
ENSG00000107105 E008 15.8568685 0.0013350386 6.823149e-02 1.404356e-01 9 23701379 23701414 36 - 1.141 0.914 -0.836
ENSG00000107105 E009 24.7176404 0.0008514666 6.164807e-04 2.593902e-03 9 23701415 23701522 108 - 1.336 0.954 -1.369
ENSG00000107105 E010 20.5854525 0.0010575590 9.569636e-03 2.770764e-02 9 23701523 23701604 82 - 1.254 0.954 -1.084
ENSG00000107105 E011 26.5294776 0.0007152429 3.456656e-02 8.083808e-02 9 23704918 23705071 154 - 1.346 1.140 -0.727
ENSG00000107105 E012 22.2311132 0.0008858210 2.215920e-01 3.523077e-01 9 23731022 23731125 104 - 1.264 1.140 -0.439
ENSG00000107105 E013 0.0000000       9 23735237 23735565 329 -      
ENSG00000107105 E014 31.5360106 0.0006828784 5.855518e-02 1.241561e-01 9 23762006 23762246 241 - 1.415 1.250 -0.576
ENSG00000107105 E015 8.2049639 0.0022708214 1.085708e-01 2.034301e-01 9 23762247 23762249 3 - 0.889 0.623 -1.078
ENSG00000107105 E016 0.7322062 0.2886134394 6.817843e-01 7.853947e-01 9 23765009 23765044 36 - 0.220 0.000 -10.547
ENSG00000107105 E017 0.3030308 0.3336267334 1.000000e+00   9 23765045 23765099 55 - 0.102 0.000 -9.250
ENSG00000107105 E018 0.0000000       9 23779237 23779375 139 -      
ENSG00000107105 E019 0.7310603 0.0934711147 7.257724e-01 8.189684e-01 9 23821227 23821480 254 - 0.184 0.254 0.589
ENSG00000107105 E020 9.4344640 0.0018762183 1.230624e-01 2.243200e-01 9 23821605 23821848 244 - 0.939 0.699 -0.942
ENSG00000107105 E021 5.9600586 0.0034734834 4.238051e-01 5.668397e-01 9 23825806 23826337 532 - 0.761 0.623 -0.576