ENSG00000106976

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000463998 ENSG00000106976 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1 protein_coding retained_intron 18.85817 20.63986 8.996403 3.806158 1.416832 -1.197109 1.7808275 1.7621212 0.9083560 0.2383101 0.19317005 -0.9483518 0.09477917 0.09063333 0.09936667 0.008733333 0.88098875 0.006685464 FALSE FALSE
ENST00000625457 ENSG00000106976 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1 protein_coding protein_coding 18.85817 20.63986 8.996403 3.806158 1.416832 -1.197109 1.0206259 2.2073469 0.6430184 0.2719829 0.32243992 -1.7636389 0.06595417 0.11666667 0.07023333 -0.046433333 0.70581106 0.006685464 FALSE FALSE
ENST00000628346 ENSG00000106976 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1 protein_coding protein_coding 18.85817 20.63986 8.996403 3.806158 1.416832 -1.197109 3.8973315 6.5585574 1.6495629 0.5330534 0.09957634 -1.9847732 0.23194167 0.33086667 0.18880000 -0.142066667 0.02649351 0.006685464 FALSE TRUE
ENST00000630850 ENSG00000106976 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1 protein_coding retained_intron 18.85817 20.63986 8.996403 3.806158 1.416832 -1.197109 0.9323096 0.6520375 0.8498336 0.1324909 0.02082600 0.3771447 0.06385000 0.03350000 0.09856667 0.065066667 0.01470798 0.006685464 FALSE TRUE
ENST00000635859 ENSG00000106976 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1 protein_coding processed_transcript 18.85817 20.63986 8.996403 3.806158 1.416832 -1.197109 1.7467483 0.5240460 0.0000000 0.5240460 0.00000000 -5.7388921 0.08052083 0.02560000 0.00000000 -0.025600000 0.91565017 0.006685464   FALSE
ENST00000636220 ENSG00000106976 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1 protein_coding processed_transcript 18.85817 20.63986 8.996403 3.806158 1.416832 -1.197109 2.9841772 4.3909994 0.6029759 2.8791345 0.60297587 -2.8439290 0.11606667 0.17446667 0.07706667 -0.097400000 0.55760562 0.006685464   FALSE
ENST00000637317 ENSG00000106976 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1 protein_coding processed_transcript 18.85817 20.63986 8.996403 3.806158 1.416832 -1.197109 1.8169796 0.0000000 1.2294316 0.0000000 1.22943162 6.9535349 0.06700000 0.00000000 0.10403333 0.104033333 0.72551897 0.006685464   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106976 E001 0.0000000       9 128191655 128191703 49 +      
ENSG00000106976 E002 0.0000000       9 128191721 128191780 60 +      
ENSG00000106976 E003 1.5489136 0.0098185639 1.429957e-01 2.521207e-01 9 128203379 128203387 9 + 0.558 0.304 -1.368
ENSG00000106976 E004 3.2042886 0.0080953063 2.481798e-01 3.837834e-01 9 128203388 128203395 8 + 0.714 0.535 -0.784
ENSG00000106976 E005 3.3525818 0.0156588611 3.227473e-01 4.660820e-01 9 128203396 128203396 1 + 0.714 0.559 -0.672
ENSG00000106976 E006 3.5740270 0.0050045466 3.872952e-01 5.314379e-01 9 128203397 128203398 2 + 0.714 0.584 -0.560
ENSG00000106976 E007 3.7954722 0.0041529349 4.682191e-01 6.076443e-01 9 128203399 128203399 1 + 0.714 0.606 -0.460
ENSG00000106976 E008 4.4189236 0.0036687773 1.528733e-01 2.655570e-01 9 128203400 128203405 6 + 0.829 0.628 -0.826
ENSG00000106976 E009 4.4125809 0.0038094123 1.531659e-01 2.659824e-01 9 128203406 128203407 2 + 0.829 0.628 -0.826
ENSG00000106976 E010 5.8434643 0.0029493472 5.987459e-02 1.264020e-01 9 128203408 128203414 7 + 0.946 0.704 -0.951
ENSG00000106976 E011 5.9917575 0.0028759965 7.794992e-02 1.561826e-01 9 128203415 128203415 1 + 0.946 0.721 -0.880
ENSG00000106976 E012 5.9917575 0.0028759965 7.794992e-02 1.561826e-01 9 128203416 128203416 1 + 0.946 0.721 -0.880
ENSG00000106976 E013 13.9033340 0.0013274197 2.127505e-01 3.417787e-01 9 128203417 128203470 54 + 1.194 1.077 -0.418
ENSG00000106976 E014 28.4269672 0.0010526291 2.994120e-01 4.409104e-01 9 128203471 128203631 161 + 1.450 1.379 -0.245
ENSG00000106976 E015 0.0000000       9 128204822 128204880 59 +      
ENSG00000106976 E016 13.8280594 0.0023419654 3.515259e-01 4.957680e-01 9 128218231 128218242 12 + 1.017 1.120 0.373
ENSG00000106976 E017 17.7720111 0.0018326198 3.977654e-01 5.415334e-01 9 128218243 128218268 26 + 1.132 1.216 0.300
ENSG00000106976 E018 21.2163929 0.0026923505 5.020421e-01 6.381594e-01 9 128218269 128218304 36 + 1.222 1.286 0.223
ENSG00000106976 E019 30.8686585 0.0007050202 2.174810e-01 3.473513e-01 9 128218582 128218665 84 + 1.488 1.407 -0.279
ENSG00000106976 E020 25.7591290 0.0008114493 2.305608e-01 3.631328e-01 9 128218666 128218731 66 + 1.425 1.340 -0.294
ENSG00000106976 E021 1.1145163 0.0203290674 1.915605e-02 4.967364e-02 9 128218858 128219048 191 + 0.558 0.148 -2.688
ENSG00000106976 E022 57.2666450 0.0004655594 5.998167e-01 7.211573e-01 9 128219049 128219252 204 + 1.709 1.685 -0.079
ENSG00000106976 E023 36.7892782 0.0005600118 1.260576e-01 2.286598e-01 9 128219988 128220086 99 + 1.575 1.483 -0.315
ENSG00000106976 E024 56.5278605 0.0016662700 4.389913e-01 5.807693e-01 9 128220181 128220341 161 + 1.713 1.676 -0.128
ENSG00000106976 E025 0.0000000       9 128221110 128221216 107 +      
ENSG00000106976 E026 51.1760495 0.0004467299 2.399971e-01 3.741379e-01 9 128222197 128222339 143 + 1.593 1.663 0.239
ENSG00000106976 E027 39.2401118 0.0005692056 5.207057e-01 6.546556e-01 9 128222461 128222528 68 + 1.503 1.547 0.152
ENSG00000106976 E028 40.6564869 0.0005438604 9.039353e-01 9.428759e-01 9 128222529 128222596 68 + 1.544 1.555 0.038
ENSG00000106976 E029 34.4314963 0.0008135873 8.566993e-01 9.114036e-01 9 128222793 128222860 68 + 1.488 1.480 -0.029
ENSG00000106976 E030 17.1395968 0.0010415389 4.382582e-07 3.920793e-06 9 128222861 128223954 1094 + 1.466 1.055 -1.449
ENSG00000106976 E031 40.9538479 0.0105021204 2.945689e-01 4.356650e-01 9 128224251 128224389 139 + 1.481 1.574 0.317
ENSG00000106976 E032 4.1171259 0.0042898178 1.506822e-01 2.625960e-01 9 128226035 128226086 52 + 0.794 0.584 -0.879
ENSG00000106976 E033 3.2315303 0.0373356802 6.415893e-01 7.545764e-01 9 128226087 128226137 51 + 0.616 0.539 -0.348
ENSG00000106976 E034 2.9671221 0.0211457790 8.921116e-01 9.350987e-01 9 128226138 128226173 36 + 0.558 0.537 -0.097
ENSG00000106976 E035 10.3351289 0.0654870542 8.963377e-01 9.377307e-01 9 128231986 128232124 139 + 0.947 0.992 0.169
ENSG00000106976 E036 8.5916693 0.0023850555 2.129625e-01 3.420178e-01 9 128232571 128232634 64 + 1.017 0.875 -0.535
ENSG00000106976 E037 6.8287000 0.0050962066 1.055339e-01 1.989163e-01 9 128232636 128232731 96 + 0.971 0.769 -0.779
ENSG00000106976 E038 20.8216334 0.0027250299 4.605802e-01 6.005844e-01 9 128233564 128234020 457 + 1.319 1.261 -0.204
ENSG00000106976 E039 42.7344735 0.0034409878 2.278103e-01 3.598027e-01 9 128234021 128234107 87 + 1.503 1.589 0.296
ENSG00000106976 E040 0.4031496 0.0242039037 6.095383e-01 7.290285e-01 9 128234816 128234935 120 + 0.000 0.148 9.887
ENSG00000106976 E041 49.5385148 0.0022808947 3.659775e-01 5.103079e-01 9 128239445 128239515 71 + 1.581 1.641 0.206
ENSG00000106976 E042 48.0700092 0.0005314221 5.950799e-01 7.172283e-01 9 128239728 128239779 52 + 1.593 1.627 0.117
ENSG00000106976 E043 13.5576937 0.0018619547 2.505948e-01 3.866437e-01 9 128239985 128239996 12 + 1.179 1.070 -0.393
ENSG00000106976 E044 4.7241990 0.0672368771 1.090011e-01 2.040648e-01 9 128240427 128240483 57 + 0.410 0.747 1.545
ENSG00000106976 E045 4.7899641 0.0978144807 3.069114e-01 4.490908e-01 9 128240484 128240511 28 + 0.490 0.737 1.092
ENSG00000106976 E046 3.8708738 0.0498064601 9.255874e-01 9.571545e-01 9 128240512 128240532 21 + 0.616 0.613 -0.014
ENSG00000106976 E047 2.7324147 0.0055183652 6.397170e-02 1.333060e-01 9 128240637 128240687 51 + 0.714 0.419 -1.365
ENSG00000106976 E048 3.9503090 0.0108759671 4.782988e-01 6.167247e-01 9 128240748 128240986 239 + 0.714 0.607 -0.458
ENSG00000106976 E049 1.5082278 0.0151861846 2.957633e-01 4.369165e-01 9 128240987 128241047 61 + 0.490 0.304 -1.043
ENSG00000106976 E050 55.8628760 0.0012031066 2.741892e-01 4.133194e-01 9 128242232 128242305 74 + 1.637 1.701 0.220
ENSG00000106976 E051 46.1131490 0.0005357573 9.903261e-02 1.889882e-01 9 128242306 128242345 40 + 1.524 1.627 0.353
ENSG00000106976 E052 69.9551119 0.0004069692 8.215809e-03 2.433110e-02 9 128246394 128246503 110 + 1.672 1.808 0.461
ENSG00000106976 E053 0.6265839 0.1041536289 2.549682e-01 3.917420e-01 9 128246937 128247123 187 + 0.000 0.255 10.495
ENSG00000106976 E054 0.1451727 0.0425701759 1.838312e-01   9 128247325 128247374 50 + 0.183 0.000 -11.363
ENSG00000106976 E055 62.4570693 0.0006314732 5.845673e-04 2.476509e-03 9 128247375 128247486 112 + 1.581 1.772 0.650
ENSG00000106976 E056 26.2033079 0.0113972410 8.118163e-02 1.613845e-01 9 128247924 128247935 12 + 1.236 1.407 0.597
ENSG00000106976 E057 2.7992476 0.3330312027 9.867249e-01 9.957716e-01 9 128247936 128248582 647 + 0.491 0.529 0.179
ENSG00000106976 E058 83.6085226 0.0003447270 1.391517e-02 3.803364e-02 9 128248583 128248753 171 + 1.767 1.882 0.389
ENSG00000106976 E059 63.6820338 0.0004112572 2.784605e-01 4.181278e-01 9 128250115 128250330 216 + 1.695 1.754 0.199
ENSG00000106976 E060 10.1906155 0.0523714154 8.181219e-01 8.850393e-01 9 128250331 128250356 26 + 0.995 0.977 -0.070
ENSG00000106976 E061 19.0026274 0.0224102034 1.456336e-01 2.557149e-01 9 128250725 128250801 77 + 1.341 1.192 -0.524
ENSG00000106976 E062 28.3616327 0.0064508914 1.534575e-01 2.663683e-01 9 128250802 128250938 137 + 1.473 1.367 -0.369
ENSG00000106976 E063 17.5957216 0.0012753088 7.911494e-01 8.664286e-01 9 128250939 128250940 2 + 1.208 1.188 -0.072
ENSG00000106976 E064 39.3315694 0.0009662073 5.915515e-22 4.683145e-20 9 128250941 128253100 2160 + 1.870 1.332 -1.836
ENSG00000106976 E065 6.0722964 0.0027516985 1.554766e-01 2.690258e-01 9 128253101 128253101 1 + 0.920 0.737 -0.714
ENSG00000106976 E066 8.6323828 0.0019530088 5.324319e-02 1.149161e-01 9 128253102 128253126 25 + 1.078 0.862 -0.805
ENSG00000106976 E067 7.6662363 0.0021817039 2.464406e-02 6.114842e-02 9 128253127 128253137 11 + 1.059 0.797 -0.987
ENSG00000106976 E068 11.0946327 0.0049405469 5.484729e-06 3.868449e-05 9 128253138 128253784 647 + 1.319 0.862 -1.662
ENSG00000106976 E069 4.7496782 0.0904011062 3.739007e-02 8.620886e-02 9 128253785 128253887 103 + 0.948 0.567 -1.549
ENSG00000106976 E070 4.2972334 0.0568641637 2.877494e-01 4.282705e-01 9 128253888 128254005 118 + 0.795 0.609 -0.772
ENSG00000106976 E071 11.2860618 0.0022722372 9.545089e-01 9.754760e-01 9 128254006 128254008 3 + 1.017 1.014 -0.010
ENSG00000106976 E072 196.9378157 0.0002698990 3.804692e-04 1.699209e-03 9 128254009 128254649 641 + 2.141 2.249 0.360
ENSG00000106976 E073 41.1273020 0.0005874325 8.679161e-01 9.190616e-01 9 128254650 128254653 4 + 1.556 1.550 -0.022
ENSG00000106976 E074 182.5455648 0.0082183725 5.131994e-02 1.115045e-01 9 128254654 128255248 595 + 2.114 2.221 0.357