ENSG00000106948

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307564 ENSG00000106948 HEK293_OSMI2_2hA HEK293_TMG_2hB AKNA protein_coding protein_coding 1.417033 2.063792 1.161196 0.07458035 0.05938258 -0.8242891 0.09905877 0.09801584 0.06713007 0.03693176 0.01196985 -0.4858776 0.07857917 0.04873333 0.05893333 0.0102000 0.96588405 0.02157982 FALSE TRUE
ENST00000312033 ENSG00000106948 HEK293_OSMI2_2hA HEK293_TMG_2hB AKNA protein_coding protein_coding 1.417033 2.063792 1.161196 0.07458035 0.05938258 -0.8242891 0.13053814 0.04920659 0.20878052 0.04920659 0.02652999 1.8856545 0.10247083 0.02230000 0.17873333 0.1564333 0.02157982 0.02157982 FALSE TRUE
ENST00000374075 ENSG00000106948 HEK293_OSMI2_2hA HEK293_TMG_2hB AKNA protein_coding protein_coding 1.417033 2.063792 1.161196 0.07458035 0.05938258 -0.8242891 0.67209615 1.08977019 0.46087369 0.06162821 0.05319235 -1.2237901 0.50395417 0.52840000 0.40330000 -0.1251000 0.44747097 0.02157982 FALSE TRUE
ENST00000374079 ENSG00000106948 HEK293_OSMI2_2hA HEK293_TMG_2hB AKNA protein_coding protein_coding 1.417033 2.063792 1.161196 0.07458035 0.05938258 -0.8242891 0.43394640 0.79387516 0.37465593 0.09821546 0.08502708 -1.0634029 0.26230417 0.38536667 0.31806667 -0.0673000 0.79351916 0.02157982 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106948 E001 0.8856816 0.1471868761 0.750600247 0.837232784 9 114334156 114336127 1972 - 0.292 0.223 -0.511
ENSG00000106948 E002 0.0000000       9 114336128 114336130 3 -      
ENSG00000106948 E003 1.5082278 0.0211302310 0.441249208 0.582889428 9 114336131 114336164 34 - 0.465 0.324 -0.789
ENSG00000106948 E004 55.2260531 0.0006363068 0.001626472 0.006045681 9 114336165 114337306 1142 - 1.589 1.742 0.520
ENSG00000106948 E005 15.7507161 0.0012697320 0.131038336 0.235594421 9 114341533 114341725 193 - 1.079 1.217 0.493
ENSG00000106948 E006 11.2413034 0.0015767675 0.998100035 1.000000000 9 114342009 114342125 117 - 1.043 1.040 -0.013
ENSG00000106948 E007 10.1188381 0.0018709362 0.422493371 0.565627120 9 114343708 114343803 96 - 1.062 0.974 -0.324
ENSG00000106948 E008 2.3018440 0.2618730363 0.179936229 0.301104828 9 114343804 114345862 2059 - 0.682 0.372 -1.490
ENSG00000106948 E009 12.2972699 0.0015174856 0.010845504 0.030795549 9 114345863 114346009 147 - 1.237 0.994 -0.878
ENSG00000106948 E010 10.8408992 0.0024095842 0.166761456 0.283972041 9 114346669 114346784 116 - 1.128 0.984 -0.527
ENSG00000106948 E011 7.0384152 0.0026544638 0.987727708 0.996405752 9 114347724 114347772 49 - 0.859 0.857 -0.005
ENSG00000106948 E012 10.2906078 0.0020742148 0.280544032 0.420396644 9 114347773 114347900 128 - 0.913 1.031 0.441
ENSG00000106948 E013 0.1482932 0.0414714906 1.000000000   9 114348887 114348999 113 - 0.000 0.087 8.993
ENSG00000106948 E014 6.9861118 0.0034771063 0.051193067 0.111278481 9 114350859 114351021 163 - 0.638 0.908 1.082
ENSG00000106948 E015 9.0947618 0.0020097134 0.391136482 0.535071745 9 114355925 114356125 201 - 0.886 0.984 0.366
ENSG00000106948 E016 5.6505069 0.0034022329 0.344039623 0.488088942 9 114356126 114356136 11 - 0.684 0.815 0.531
ENSG00000106948 E017 7.9711756 0.0022283627 0.348791738 0.493013993 9 114356863 114356969 107 - 0.829 0.942 0.431
ENSG00000106948 E018 12.3356071 0.0015721906 0.279603185 0.419364933 9 114357921 114358167 247 - 1.004 1.112 0.394
ENSG00000106948 E019 0.0000000       9 114358168 114358337 170 -      
ENSG00000106948 E020 0.0000000       9 114359087 114359593 507 -      
ENSG00000106948 E021 9.2723411 0.0020221745 0.664557628 0.772368907 9 114359594 114359794 201 - 0.937 0.984 0.172
ENSG00000106948 E022 11.0964662 0.0028515747 0.007100599 0.021489986 9 114359896 114360062 167 - 1.213 0.942 -0.983
ENSG00000106948 E023 12.2129403 0.0015167634 0.150674647 0.262585297 9 114361704 114361911 208 - 1.173 1.031 -0.511
ENSG00000106948 E024 7.6617017 0.0149398151 0.170627356 0.288970702 9 114362406 114362533 128 - 0.762 0.950 0.727
ENSG00000106948 E025 6.7467365 0.0684841548 0.487837058 0.625473015 9 114364560 114364619 60 - 0.762 0.887 0.490
ENSG00000106948 E026 9.8749375 0.0019121334 0.322289551 0.465603090 9 114367543 114367697 155 - 0.913 1.022 0.406
ENSG00000106948 E027 0.1472490 0.0426661715 0.229508604   9 114368200 114368246 47 - 0.170 0.000 -11.263
ENSG00000106948 E028 12.2292067 0.0014772817 0.627358315 0.743172302 9 114368439 114368595 157 - 1.043 1.089 0.167
ENSG00000106948 E029 7.7340157 0.0022901288 0.213357399 0.342495248 9 114374093 114374167 75 - 1.004 0.857 -0.554
ENSG00000106948 E030 32.7379379 0.0054010651 0.104971588 0.198051532 9 114376466 114377532 1067 - 1.556 1.442 -0.390
ENSG00000106948 E031 0.1451727 0.0431534602 0.229274579   9 114377533 114377635 103 - 0.170 0.000 -11.261
ENSG00000106948 E032 7.2246808 0.0028456881 0.003583038 0.011963480 9 114381060 114381446 387 - 1.079 0.735 -1.313
ENSG00000106948 E033 0.0000000       9 114387860 114388081 222 -      
ENSG00000106948 E034 1.3651183 0.0099304660 0.735633969 0.826348346 9 114394357 114394405 49 - 0.387 0.324 -0.375