ENSG00000106829

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265284 ENSG00000106829 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE4 protein_coding protein_coding 28.02581 21.48979 29.1564 0.8353189 0.3846605 0.4399846 1.7551498 1.84050288 1.2470393 0.66720129 0.2374645 -0.5578877 0.06541667 0.084100000 0.04303333 -0.0410666667 5.247956e-01 1.577383e-07 FALSE TRUE
ENST00000376544 ENSG00000106829 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE4 protein_coding protein_coding 28.02581 21.48979 29.1564 0.8353189 0.3846605 0.4399846 1.8371941 1.25208480 1.7082633 0.17330453 0.6866130 0.4451423 0.06317917 0.057966667 0.05883333 0.0008666667 9.225299e-01 1.577383e-07 FALSE TRUE
ENST00000376552 ENSG00000106829 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE4 protein_coding protein_coding 28.02581 21.48979 29.1564 0.8353189 0.3846605 0.4399846 9.7269461 5.54828168 11.5402572 0.34501507 0.5403877 1.0552141 0.33931667 0.260133333 0.39566667 0.1355333333 1.253134e-02 1.577383e-07 FALSE TRUE
ENST00000490347 ENSG00000106829 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE4 protein_coding protein_coding 28.02581 21.48979 29.1564 0.8353189 0.3846605 0.4399846 2.9589836 0.70231463 4.4408370 0.70231463 0.7691759 2.6434901 0.10088333 0.034166667 0.15306667 0.1189000000 1.097670e-01 1.577383e-07 FALSE TRUE
MSTRG.32903.11 ENSG00000106829 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE4 protein_coding   28.02581 21.48979 29.1564 0.8353189 0.3846605 0.4399846 2.1501601 0.00000000 1.3595997 0.00000000 1.3595997 7.0976104 0.07158750 0.000000000 0.04620000 0.0462000000 8.962149e-01 1.577383e-07 FALSE TRUE
MSTRG.32903.12 ENSG00000106829 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE4 protein_coding   28.02581 21.48979 29.1564 0.8353189 0.3846605 0.4399846 2.7020010 3.74752613 0.8221504 0.40440244 0.8221504 -2.1748669 0.10183333 0.176300000 0.02793333 -0.1483666667 7.222373e-02 1.577383e-07 FALSE TRUE
MSTRG.32903.13 ENSG00000106829 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE4 protein_coding   28.02581 21.48979 29.1564 0.8353189 0.3846605 0.4399846 0.7465201 0.07402705 1.9573825 0.04317598 0.4278316 4.5492799 0.02326250 0.003333333 0.06703333 0.0637000000 1.577383e-07 1.577383e-07 FALSE TRUE
MSTRG.32903.25 ENSG00000106829 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE4 protein_coding   28.02581 21.48979 29.1564 0.8353189 0.3846605 0.4399846 1.9617202 3.90092368 1.9992711 0.58711037 1.0115749 -0.9608372 0.07553333 0.180533333 0.06906667 -0.1114666667 5.631040e-01 1.577383e-07 FALSE TRUE
MSTRG.32903.27 ENSG00000106829 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE4 protein_coding   28.02581 21.48979 29.1564 0.8353189 0.3846605 0.4399846 0.8517504 1.61429468 0.4565339 0.87258688 0.4565339 -1.7997597 0.03311667 0.072800000 0.01550000 -0.0573000000 4.710402e-01 1.577383e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106829 E001 1.0695761 0.0121185074 3.639252e-01 5.083393e-01 9 79571773 79571940 168 + 0.205 0.381 1.213
ENSG00000106829 E002 16.3596552 0.0124775586 1.180540e-01 2.171463e-01 9 79571941 79571964 24 + 1.302 1.176 -0.446
ENSG00000106829 E003 208.5416821 0.0086055628 2.856568e-05 1.707586e-04 9 79571965 79572574 610 + 2.408 2.218 -0.631
ENSG00000106829 E004 10.8594451 0.0080025216 7.281934e-11 1.314850e-09 9 79572575 79572591 17 + 1.315 0.538 -3.002
ENSG00000106829 E005 11.8090977 0.0023990304 1.299994e-15 4.848987e-14 9 79572592 79572610 19 + 1.369 0.439 -3.676
ENSG00000106829 E006 9.7161508 0.0017623585 1.106259e-14 3.614650e-13 9 79572611 79572614 4 + 1.296 0.312 -4.157
ENSG00000106829 E007 11.3413144 0.0018661402 3.371807e-16 1.356506e-14 9 79572615 79572624 10 + 1.357 0.380 -3.958
ENSG00000106829 E008 11.6432985 0.0017125117 2.947362e-14 9.048272e-13 9 79572625 79572633 9 + 1.352 0.492 -3.353
ENSG00000106829 E009 11.6579585 0.0109088659 1.425352e-10 2.451018e-09 9 79572634 79572637 4 + 1.340 0.580 -2.897
ENSG00000106829 E010 28.1641007 0.0008381615 1.732525e-11 3.467375e-10 9 79572638 79572711 74 + 1.637 1.206 -1.492
ENSG00000106829 E011 27.2390303 0.0007851004 1.439341e-05 9.216791e-05 9 79572712 79572744 33 + 1.568 1.307 -0.902
ENSG00000106829 E012 59.6455719 0.0074061377 1.723601e-03 6.356948e-03 9 79572745 79572835 91 + 1.860 1.691 -0.570
ENSG00000106829 E013 0.7331366 0.0180189512 1.980506e-01 3.237742e-01 9 79573218 79573251 34 + 0.344 0.130 -1.790
ENSG00000106829 E014 0.7331366 0.0180189512 1.980506e-01 3.237742e-01 9 79573252 79573261 10 + 0.344 0.130 -1.790
ENSG00000106829 E015 0.7331366 0.0180189512 1.980506e-01 3.237742e-01 9 79573262 79573263 2 + 0.344 0.130 -1.790
ENSG00000106829 E016 0.8783093 0.0331893743 1.167599e-01 2.153367e-01 9 79573264 79573296 33 + 0.400 0.130 -2.112
ENSG00000106829 E017 0.7374030 0.0153787590 1.968064e-01 3.222494e-01 9 79573297 79573317 21 + 0.344 0.130 -1.790
ENSG00000106829 E018 10.8305457 0.0104743749 1.832413e-02 4.784184e-02 9 79573318 79573370 53 + 1.182 0.955 -0.826
ENSG00000106829 E019 0.7363589 0.0154370120 2.118360e-02 5.398397e-02 9 79573503 79573688 186 + 0.400 0.000 -14.313
ENSG00000106829 E020 105.9712703 0.0023943830 3.021345e-02 7.238872e-02 9 79573689 79573786 98 + 2.059 1.998 -0.204
ENSG00000106829 E021 0.1451727 0.0436114206 5.296255e-01   9 79573933 79574196 264 + 0.115 0.000 -11.991
ENSG00000106829 E022 106.5819094 0.0013670585 3.137671e-02 7.463680e-02 9 79574873 79574936 64 + 2.056 2.004 -0.176
ENSG00000106829 E023 0.0000000       9 79574937 79575029 93 +      
ENSG00000106829 E024 0.1817044 0.0424954086 4.501711e-01   9 79575779 79575779 1 + 0.000 0.130 12.141
ENSG00000106829 E025 0.1817044 0.0424954086 4.501711e-01   9 79575780 79576027 248 + 0.000 0.130 12.141
ENSG00000106829 E026 100.9766860 0.0017306726 6.691980e-02 1.382525e-01 9 79576133 79576177 45 + 2.029 1.985 -0.146
ENSG00000106829 E027 0.1515154 0.0439804766 5.290192e-01   9 79576178 79576283 106 + 0.115 0.000 -11.992
ENSG00000106829 E028 0.1472490 0.0435055164 5.295415e-01   9 79576475 79576802 328 + 0.115 0.000 -11.991
ENSG00000106829 E029 0.0000000       9 79580060 79580185 126 +      
ENSG00000106829 E030 0.1817044 0.0424954086 4.501711e-01   9 79580227 79580372 146 + 0.000 0.130 12.141
ENSG00000106829 E031 0.5891098 0.0183530389 4.474665e-02 9.974136e-02 9 79601415 79601509 95 + 0.344 0.000 -13.991
ENSG00000106829 E032 111.2332301 0.0003094797 5.295085e-04 2.269851e-03 9 79612656 79612718 63 + 2.093 2.006 -0.289
ENSG00000106829 E033 95.8346849 0.0012574826 1.250161e-03 4.810624e-03 9 79627374 79627448 75 + 2.035 1.940 -0.320
ENSG00000106829 E034 0.0000000       9 79627449 79627752 304 +      
ENSG00000106829 E035 0.9859167 0.0750204261 5.173669e-01 6.517642e-01 9 79649481 79649819 339 + 0.344 0.232 -0.777
ENSG00000106829 E036 2.8076721 0.0056642947 2.105847e-01 3.392315e-01 9 79649820 79649858 39 + 0.665 0.491 -0.789
ENSG00000106829 E037 34.7627317 0.0231653938 8.249788e-01 8.897338e-01 9 79652590 79652592 3 + 1.557 1.552 -0.017
ENSG00000106829 E038 156.3234846 0.0029341704 7.276638e-02 1.479546e-01 9 79652593 79652685 93 + 2.218 2.178 -0.133
ENSG00000106829 E039 177.8519567 0.0012505534 3.628037e-05 2.112428e-04 9 79652686 79652794 109 + 2.300 2.202 -0.329
ENSG00000106829 E040 0.1482932 0.0410757710 4.533928e-01   9 79652795 79652798 4 + 0.000 0.130 12.136
ENSG00000106829 E041 0.1482932 0.0410757710 4.533928e-01   9 79652799 79652799 1 + 0.000 0.130 12.136
ENSG00000106829 E042 101.0987341 0.0002805195 3.056099e-03 1.043168e-02 9 79654059 79654075 17 + 2.046 1.972 -0.246
ENSG00000106829 E043 0.0000000       9 79663450 79663603 154 +      
ENSG00000106829 E044 0.0000000       9 79671209 79671338 130 +      
ENSG00000106829 E045 0.0000000       9 79671339 79671557 219 +      
ENSG00000106829 E046 1.3170471 0.5866435772 9.845187e-01 9.943903e-01 9 79704645 79704782 138 + 0.398 0.319 -0.463
ENSG00000106829 E047 109.3246228 0.0002765344 1.102097e-03 4.310082e-03 9 79704783 79704802 20 + 2.082 2.002 -0.268
ENSG00000106829 E048 182.1060474 0.0002275775 4.387632e-04 1.923684e-03 9 79704803 79704902 100 + 2.293 2.231 -0.208
ENSG00000106829 E049 152.5516336 0.0002441091 1.372490e-01 2.442457e-01 9 79705889 79705942 54 + 2.193 2.182 -0.040
ENSG00000106829 E050 104.9331146 0.0002835289 2.863223e-01 4.267130e-01 9 79706747 79706765 19 + 2.029 2.023 -0.021
ENSG00000106829 E051 210.3001760 0.0023096810 8.526875e-01 9.086920e-01 9 79706766 79706899 134 + 2.313 2.334 0.071
ENSG00000106829 E052 9.9279794 0.0355542242 4.880365e-01 6.256610e-01 9 79707123 79707218 96 + 1.064 0.995 -0.255
ENSG00000106829 E053 209.8078860 0.0006411964 2.104341e-01 3.390517e-01 9 79708118 79708250 133 + 2.325 2.322 -0.012
ENSG00000106829 E054 212.1956388 0.0002030103 6.690660e-01 7.759663e-01 9 79708593 79708786 194 + 2.319 2.339 0.068
ENSG00000106829 E055 140.1158800 0.0003373224 1.588565e-01 2.736296e-01 9 79709623 79709699 77 + 2.110 2.184 0.245
ENSG00000106829 E056 4.4790184 0.0037118162 3.798632e-02 8.732641e-02 9 79717997 79718071 75 + 0.848 0.580 -1.110
ENSG00000106829 E057 289.1696584 0.0002196506 6.060000e-01 7.262703e-01 9 79718722 79718971 250 + 2.441 2.483 0.138
ENSG00000106829 E058 308.7218755 0.0013316557 6.544249e-02 1.357774e-01 9 79720046 79720293 248 + 2.451 2.527 0.252
ENSG00000106829 E059 236.3522275 0.0016534326 8.035632e-04 3.271850e-03 9 79721741 79721888 148 + 2.307 2.434 0.425
ENSG00000106829 E060 271.8336040 0.0001740184 7.513872e-10 1.140975e-08 9 79722451 79722601 151 + 2.347 2.512 0.548
ENSG00000106829 E061 242.3755939 0.0001674373 2.481735e-10 4.087613e-09 9 79722959 79723035 77 + 2.289 2.465 0.588
ENSG00000106829 E062 930.0210022 0.0117247007 1.400661e-04 7.038677e-04 9 79725037 79726882 1846 + 2.849 3.060 0.703