ENSG00000106804

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000223642 ENSG00000106804 HEK293_OSMI2_2hA HEK293_TMG_2hB C5 protein_coding protein_coding 0.8130058 0.4522877 1.141141 0.04365706 0.09418922 1.316202 0.23012535 0.02991095 0.50774347 0.02991095 0.031891140 3.6973808 0.22243333 0.06143333 0.45660000 0.39516667 0.014119694 0.006365899 FALSE TRUE
ENST00000460578 ENSG00000106804 HEK293_OSMI2_2hA HEK293_TMG_2hB C5 protein_coding processed_transcript 0.8130058 0.4522877 1.141141 0.04365706 0.09418922 1.316202 0.06733024 0.00000000 0.09912384 0.00000000 0.054821103 3.4478945 0.05434167 0.00000000 0.08020000 0.08020000 0.471549778 0.006365899 FALSE TRUE
ENST00000466280 ENSG00000106804 HEK293_OSMI2_2hA HEK293_TMG_2hB C5 protein_coding processed_transcript 0.8130058 0.4522877 1.141141 0.04365706 0.09418922 1.316202 0.10377053 0.02168588 0.07296661 0.02168588 0.036566864 1.3886907 0.11365000 0.04300000 0.06743333 0.02443333 0.969711094 0.006365899 FALSE FALSE
ENST00000696279 ENSG00000106804 HEK293_OSMI2_2hA HEK293_TMG_2hB C5 protein_coding nonsense_mediated_decay 0.8130058 0.4522877 1.141141 0.04365706 0.09418922 1.316202 0.06524251 0.04418467 0.06362015 0.02279267 0.063620149 0.4422160 0.11624583 0.10180000 0.05140000 -0.05040000 0.638029927 0.006365899 TRUE TRUE
ENST00000696282 ENSG00000106804 HEK293_OSMI2_2hA HEK293_TMG_2hB C5 protein_coding retained_intron 0.8130058 0.4522877 1.141141 0.04365706 0.09418922 1.316202 0.05529603 0.03687436 0.07096004 0.01727867 0.004250895 0.7884111 0.08272917 0.08240000 0.06366667 -0.01873333 0.889650595 0.006365899 TRUE TRUE
ENST00000696283 ENSG00000106804 HEK293_OSMI2_2hA HEK293_TMG_2hB C5 protein_coding retained_intron 0.8130058 0.4522877 1.141141 0.04365706 0.09418922 1.316202 0.02407897 0.00000000 0.07387536 0.00000000 0.073875360 3.0682471 0.01821250 0.00000000 0.05993333 0.05993333 0.948628871 0.006365899 FALSE TRUE
ENST00000696284 ENSG00000106804 HEK293_OSMI2_2hA HEK293_TMG_2hB C5 protein_coding retained_intron 0.8130058 0.4522877 1.141141 0.04365706 0.09418922 1.316202 0.09988918 0.17776163 0.08575416 0.02455131 0.043086479 -0.9714952 0.15462083 0.40283333 0.07920000 -0.32363333 0.041804460 0.006365899 FALSE TRUE
ENST00000696285 ENSG00000106804 HEK293_OSMI2_2hA HEK293_TMG_2hB C5 protein_coding retained_intron 0.8130058 0.4522877 1.141141 0.04365706 0.09418922 1.316202 0.10587395 0.13758470 0.05280246 0.02913117 0.016424225 -1.2326502 0.17462917 0.29680000 0.04910000 -0.24770000 0.006365899 0.006365899   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106804 E001 0.0000000       9 120932642 120932986 345 -      
ENSG00000106804 E002 0.1482932 0.041382776 1.643894e-01   9 120932987 120933954 968 - 0.000 0.190 11.743
ENSG00000106804 E003 0.1482932 0.041382776 1.643894e-01   9 120952192 120952334 143 - 0.000 0.190 14.553
ENSG00000106804 E004 0.0000000       9 120952335 120952348 14 -      
ENSG00000106804 E005 5.5910822 0.008369281 3.656308e-01 5.099472e-01 9 120952349 120952868 520 - 0.818 0.686 -0.532
ENSG00000106804 E006 0.4407149 0.021658665 7.710367e-01 8.521907e-01 9 120952869 120953729 861 - 0.141 0.190 0.515
ENSG00000106804 E007 4.0703064 0.142871433 6.628990e-01 7.711130e-01 9 120953730 120953868 139 - 0.701 0.581 -0.518
ENSG00000106804 E008 3.1344355 0.005260814 3.774516e-01 5.217819e-01 9 120953869 120956960 3092 - 0.544 0.686 0.623
ENSG00000106804 E009 1.0371996 0.024666048 8.288753e-02 1.640647e-01 9 120956961 120957284 324 - 0.371 0.000 -15.579
ENSG00000106804 E010 3.4698228 0.004634897 1.274936e-01 2.306618e-01 9 120957285 120957368 84 - 0.686 0.423 -1.221
ENSG00000106804 E011 3.2484783 0.005032590 4.439324e-02 9.909510e-02 9 120960248 120960337 90 - 0.686 0.322 -1.806
ENSG00000106804 E012 1.9113683 0.016225150 8.046070e-01 8.756776e-01 9 120961482 120961565 84 - 0.466 0.423 -0.224
ENSG00000106804 E013 1.9691062 0.009038831 3.583001e-01 5.026837e-01 9 120962671 120962776 106 - 0.494 0.322 -0.944
ENSG00000106804 E014 1.6703418 0.010330248 5.408891e-01 6.719508e-01 9 120962893 120962967 75 - 0.436 0.322 -0.655
ENSG00000106804 E015 2.2248945 0.007196592 5.808605e-01 7.055304e-01 9 120963636 120963738 103 - 0.520 0.423 -0.486
ENSG00000106804 E016 1.9239400 0.008089422 8.004060e-01 8.727819e-01 9 120969061 120969118 58 - 0.466 0.423 -0.223
ENSG00000106804 E017 1.8455766 0.007665423 9.318979e-01 9.610886e-01 9 120970170 120970251 82 - 0.436 0.423 -0.069
ENSG00000106804 E018 0.0000000       9 120970885 120971007 123 -      
ENSG00000106804 E019 1.8467225 0.007668229 4.396947e-01 5.814441e-01 9 120971930 120971992 63 - 0.466 0.322 -0.805
ENSG00000106804 E020 3.4332911 0.004698970 3.475284e-02 8.117252e-02 9 120974779 120974931 153 - 0.702 0.322 -1.876
ENSG00000106804 E021 4.3847645 0.003922762 2.580292e-01 3.952366e-01 9 120976700 120976905 206 - 0.750 0.574 -0.747
ENSG00000106804 E022 0.1451727 0.043613206 1.000000e+00   9 120979559 120979719 161 - 0.076 0.000 -13.535
ENSG00000106804 E023 3.4836531 0.005047109 3.228188e-01 4.661574e-01 9 120980083 120980254 172 - 0.668 0.505 -0.732
ENSG00000106804 E024 1.4822947 0.010610213 2.073054e-01 3.352788e-01 9 120981844 120981939 96 - 0.436 0.190 -1.655
ENSG00000106804 E025 2.6562479 0.005958021 2.276339e-02 5.725437e-02 9 120982655 120982814 160 - 0.630 0.190 -2.572
ENSG00000106804 E026 2.0618276 0.007243862 7.048923e-03 2.135167e-02 9 120989046 120989121 76 - 0.567 0.000 -16.179
ENSG00000106804 E027 3.3580482 0.005053789 1.569653e-01 2.710523e-01 9 120989568 120989780 213 - 0.668 0.423 -1.146
ENSG00000106804 E028 1.5092494 0.009036306 2.074226e-01 3.354125e-01 9 120991191 120991280 90 - 0.436 0.190 -1.653
ENSG00000106804 E029 1.0267042 0.014377348 8.115212e-02 1.613360e-01 9 120996240 120996300 61 - 0.370 0.000 -15.583
ENSG00000106804 E030 2.9508597 0.029044327 1.749871e-02 4.604147e-02 9 120997547 120997774 228 - 0.668 0.190 -2.733
ENSG00000106804 E031 0.4449813 0.021477783 7.707331e-01 8.519855e-01 9 120999677 120999954 278 - 0.141 0.190 0.514
ENSG00000106804 E032 0.2998086 0.028909451 4.453954e-01   9 120999955 121000051 97 - 0.076 0.190 1.514
ENSG00000106804 E033 3.0333732 0.005798210 5.256551e-01 6.590021e-01 9 121005919 121006058 140 - 0.611 0.505 -0.485
ENSG00000106804 E034 2.7397936 0.005915016 3.418440e-01 4.857913e-01 9 121006904 121006977 74 - 0.590 0.423 -0.806
ENSG00000106804 E035 2.4505941 0.006540225 1.842701e-01 3.065941e-01 9 121008408 121008498 91 - 0.568 0.322 -1.291
ENSG00000106804 E036 3.6265220 0.005927769 2.717145e-01 4.104838e-01 9 121013873 121014070 198 - 0.686 0.505 -0.807
ENSG00000106804 E037 1.6220431 0.029197372 2.202433e-02 5.572896e-02 9 121015199 121015261 63 - 0.494 0.000 -15.968
ENSG00000106804 E038 2.8786236 0.005566970 2.832254e-01 4.233197e-01 9 121016254 121016383 130 - 0.610 0.423 -0.899
ENSG00000106804 E039 3.5074873 0.004441380 1.272950e-01 2.303684e-01 9 121017362 121017511 150 - 0.686 0.423 -1.220
ENSG00000106804 E040 3.4429699 0.004780106 5.510304e-03 1.731482e-02 9 121017643 121017852 210 - 0.719 0.190 -2.943
ENSG00000106804 E041 2.8914108 0.005593062 1.717059e-02 4.532126e-02 9 121019976 121020179 204 - 0.650 0.191 -2.653
ENSG00000106804 E042 2.7588098 0.513664986 2.201718e-01 3.506412e-01 9 121021509 121021694 186 - 0.633 0.196 -2.534
ENSG00000106804 E043 2.0817862 0.118138270 1.150407e-01 2.128955e-01 9 121023404 121023519 116 - 0.545 0.189 -2.197
ENSG00000106804 E044 2.2132398 0.051955284 7.326150e-01 8.240467e-01 9 121025454 121025580 127 - 0.494 0.425 -0.351
ENSG00000106804 E045 0.4375944 0.025984612 4.094517e-01 5.530597e-01 9 121025696 121025903 208 - 0.198 0.000 -14.768
ENSG00000106804 E046 2.1242792 0.066444824 3.499802e-01 4.941620e-01 9 121027160 121027274 115 - 0.404 0.576 0.851
ENSG00000106804 E047 1.2471027 0.454773365 5.626873e-01 6.902543e-01 9 121030397 121030487 91 - 0.247 0.443 1.212
ENSG00000106804 E048 1.5585526 0.159958978 7.019511e-01 8.008928e-01 9 121032113 121032195 83 - 0.334 0.432 0.558
ENSG00000106804 E049 0.9747559 0.256998178 7.164069e-01 8.120718e-01 9 121034803 121034894 92 - 0.294 0.193 -0.788
ENSG00000106804 E050 2.4861954 0.008479616 1.876287e-01 3.107568e-01 9 121037881 121037951 71 - 0.568 0.323 -1.290
ENSG00000106804 E051 0.2965864 0.102431080 4.686079e-02   9 121040985 121043003 2019 - 0.000 0.320 15.304
ENSG00000106804 E052 3.0000769 0.007359016 7.393576e-02 1.498097e-01 9 121043004 121043166 163 - 0.650 0.322 -1.654
ENSG00000106804 E053 3.2194458 0.007202534 1.956349e-01 3.207593e-01 9 121046191 121046383 193 - 0.650 0.423 -1.068
ENSG00000106804 E054 0.2214452 0.038852673 1.625697e-01   9 121050182 121050275 94 - 0.000 0.191 14.563
ENSG00000106804 E055 2.6227335 0.005767702 8.109265e-01 8.800747e-01 9 121057894 121057997 104 - 0.544 0.505 -0.184
ENSG00000106804 E056 1.8121759 0.008080581 4.701152e-02 1.038484e-01 9 121062391 121063601 1211 - 0.293 0.634 1.779
ENSG00000106804 E057 17.3586723 0.002524568 1.921328e-25 2.196680e-23 9 121067143 121067564 422 - 0.778 1.621 3.027
ENSG00000106804 E058 0.4448795 0.361946895 4.300164e-02 9.654462e-02 9 121074174 121074753 580 - 0.000 0.411 15.440
ENSG00000106804 E059 6.1819035 0.003220097 6.322345e-10 9.740968e-09 9 121074754 121075030 277 - 0.436 1.200 3.102
ENSG00000106804 E060 2.7343893 0.016706971 2.960964e-03 1.014735e-02 9 121075031 121075195 165 - 0.333 0.814 2.255