ENSG00000106799

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374990 ENSG00000106799 HEK293_OSMI2_2hA HEK293_TMG_2hB TGFBR1 protein_coding protein_coding 9.7802 2.446471 17.79925 0.4640696 0.4756744 2.857968 0.3849217 0.32469818 0.162061 0.16530369 0.1620610 -0.9599410 0.05875417 0.12016667 0.00890000 -0.1112667 0.2349580290 0.0001819479 FALSE TRUE
ENST00000374994 ENSG00000106799 HEK293_OSMI2_2hA HEK293_TMG_2hB TGFBR1 protein_coding protein_coding 9.7802 2.446471 17.79925 0.4640696 0.4756744 2.857968 4.4279831 0.05853696 14.557855 0.05853696 1.8734244 7.7316906 0.28367917 0.03226667 0.81340000 0.7811333 0.0001819479 0.0001819479 FALSE TRUE
ENST00000552516 ENSG00000106799 HEK293_OSMI2_2hA HEK293_TMG_2hB TGFBR1 protein_coding protein_coding 9.7802 2.446471 17.79925 0.4640696 0.4756744 2.857968 1.1359602 0.04919017 2.012326 0.04919017 0.4462306 5.0945143 0.09755000 0.01466667 0.11436667 0.0997000 0.0459096008 0.0001819479 FALSE TRUE
MSTRG.33137.7 ENSG00000106799 HEK293_OSMI2_2hA HEK293_TMG_2hB TGFBR1 protein_coding   9.7802 2.446471 17.79925 0.4640696 0.4756744 2.857968 3.4406629 1.90026990 1.024793 0.38707096 1.0247928 -0.8844345 0.52090000 0.78056667 0.06083333 -0.7197333 0.0102531168 0.0001819479 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106799 E001 0.0000000       9 99104038 99104069 32 +      
ENSG00000106799 E002 0.0000000       9 99104070 99104106 37 +      
ENSG00000106799 E003 1.0288943 0.2414568535 5.456159e-01 6.759215e-01 9 99105111 99105112 2 + 0.269 0.000 -10.342
ENSG00000106799 E004 5.0264049 0.0031380359 4.985139e-03 1.588809e-02 9 99105113 99105149 37 + 0.715 0.000 -14.828
ENSG00000106799 E005 20.8859091 0.0009085081 3.723953e-05 2.162626e-04 9 99105150 99105302 153 + 1.252 0.647 -2.294
ENSG00000106799 E006 0.1482932 0.0411597534 4.769824e-02   9 99119135 99119207 73 + 0.000 0.269 11.610
ENSG00000106799 E007 0.0000000       9 99127775 99127873 99 +      
ENSG00000106799 E008 0.0000000       9 99127874 99127915 42 +      
ENSG00000106799 E009 0.0000000       9 99127916 99127933 18 +      
ENSG00000106799 E010 0.1451727 0.0445408063 7.889270e-01   9 99127934 99128002 69 + 0.050 0.000 -9.059
ENSG00000106799 E011 0.0000000       9 99128836 99128854 19 +      
ENSG00000106799 E012 79.5312189 0.0042455277 8.926968e-08 9.146497e-07 9 99128855 99129100 246 + 1.802 1.383 -1.428
ENSG00000106799 E013 3.9338072 0.0369488526 4.539783e-01 5.946778e-01 9 99132497 99132508 12 + 0.597 0.435 -0.781
ENSG00000106799 E014 106.0871443 0.0054569679 2.633033e-07 2.465014e-06 9 99132509 99132739 231 + 1.921 1.558 -1.229
ENSG00000106799 E015 113.7144987 0.0003265782 1.319168e-06 1.067409e-05 9 99137859 99138089 231 + 1.943 1.684 -0.874
ENSG00000106799 E016 81.4008536 0.0003438779 7.852320e-04 3.206584e-03 9 99142536 99142703 168 + 1.795 1.589 -0.696
ENSG00000106799 E017 87.1538250 0.0030884858 1.087114e-04 5.621842e-04 9 99144732 99144888 157 + 1.830 1.569 -0.885
ENSG00000106799 E018 96.5962011 0.0002870707 1.089267e-06 8.969763e-06 9 99146485 99146609 125 + 1.876 1.589 -0.973
ENSG00000106799 E019 101.2131182 0.0015830104 1.539004e-10 2.630693e-09 9 99147654 99147784 131 + 1.905 1.480 -1.440
ENSG00000106799 E020 1212.4700074 0.0001826773 8.529224e-61 8.927270e-58 9 99149180 99154192 5013 + 2.916 3.048 0.439