ENSG00000106771

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374586 ENSG00000106771 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM245 protein_coding protein_coding 15.77258 7.569608 21.97362 0.3315325 0.3453194 1.536234 8.2917505 3.08893755 12.656834 0.27879192 0.5005478 2.0312104 0.50773750 0.409433333 0.5755667 0.16613333 1.530751e-02 9.467171e-17 FALSE TRUE
ENST00000413712 ENSG00000106771 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM245 protein_coding protein_coding 15.77258 7.569608 21.97362 0.3315325 0.3453194 1.536234 4.3643417 3.44678574 4.051103 0.06451114 0.1242810 0.2324404 0.32077917 0.456666667 0.1843333 -0.27233333 9.467171e-17 9.467171e-17 FALSE TRUE
ENST00000491854 ENSG00000106771 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM245 protein_coding nonsense_mediated_decay 15.77258 7.569608 21.97362 0.3315325 0.3453194 1.536234 1.9150788 0.89263866 2.823999 0.31117546 0.2086984 1.6506185 0.11090000 0.115533333 0.1287333 0.01320000 8.518520e-01 9.467171e-17 FALSE TRUE
MSTRG.33202.2 ENSG00000106771 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM245 protein_coding   15.77258 7.569608 21.97362 0.3315325 0.3453194 1.536234 0.6025306 0.05768008 1.276887 0.03674877 0.1002312 4.2490108 0.02733333 0.007266667 0.0582000 0.05093333 2.398750e-05 9.467171e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106771 E001 411.2880397 0.0099998890 1.340207e-02 3.685025e-02 9 109015135 109016508 1374 - 2.523 2.662 0.465
ENSG00000106771 E002 545.0051189 0.0001865999 6.112352e-23 5.383388e-21 9 109016509 109018925 2417 - 2.725 2.570 -0.517
ENSG00000106771 E003 230.5605414 0.0001910240 2.071309e-27 2.788936e-25 9 109018926 109019903 978 - 2.379 2.075 -1.013
ENSG00000106771 E004 63.9409000 0.0070469108 2.224708e-01 3.533344e-01 9 109019904 109020087 184 - 1.737 1.828 0.307
ENSG00000106771 E005 192.8912649 0.0004859483 3.720611e-14 1.124535e-12 9 109020088 109020505 418 - 2.162 2.393 0.769
ENSG00000106771 E006 157.2245225 0.0032525790 1.491030e-05 9.522675e-05 9 109033307 109033501 195 - 2.090 2.279 0.633
ENSG00000106771 E007 0.1451727 0.0433969789 1.000000e+00   9 109036020 109036205 186 - 0.072 0.001 -7.003
ENSG00000106771 E008 146.0953743 0.0002506629 3.105454e-06 2.315305e-05 9 109036206 109036380 175 - 2.066 2.232 0.555
ENSG00000106771 E009 105.4878398 0.0006292735 2.646462e-03 9.210667e-03 9 109038017 109038117 101 - 1.935 2.069 0.450
ENSG00000106771 E010 7.3609540 0.1016478987 1.632581e-01 2.794084e-01 9 109038118 109039327 1210 - 0.924 0.666 -1.024
ENSG00000106771 E011 141.2065959 0.0009306022 1.847721e-03 6.751373e-03 9 109050283 109050428 146 - 2.064 2.190 0.421
ENSG00000106771 E012 128.7231232 0.0023776075 4.227462e-02 9.522837e-02 9 109050570 109050692 123 - 2.033 2.132 0.331
ENSG00000106771 E013 128.7530883 0.0002585481 4.336381e-01 5.760517e-01 9 109057191 109057322 132 - 2.050 2.096 0.157
ENSG00000106771 E014 98.0077973 0.0003347443 6.719739e-01 7.780935e-01 9 109060354 109060452 99 - 1.947 1.950 0.009
ENSG00000106771 E015 95.4130897 0.0003612835 8.833638e-02 1.725851e-01 9 109064477 109064567 91 - 1.950 1.898 -0.173
ENSG00000106771 E016 1.2618922 0.1576590136 9.434551e-01 9.685314e-01 9 109073248 109073355 108 - 0.319 0.338 0.119
ENSG00000106771 E017 78.8742177 0.0003738973 3.357354e-01 4.795349e-01 9 109073356 109073438 83 - 1.860 1.836 -0.082
ENSG00000106771 E018 76.4263844 0.0008197418 6.572608e-01 7.666492e-01 9 109080839 109080943 105 - 1.831 1.871 0.136
ENSG00000106771 E019 0.5922303 0.0179901688 1.000000e+00 1.000000e+00 9 109085997 109086020 24 - 0.188 0.200 0.116
ENSG00000106771 E020 97.3672983 0.0003836397 4.676307e-01 6.071303e-01 9 109087173 109087342 170 - 1.948 1.938 -0.033
ENSG00000106771 E021 132.3723484 0.0007527326 1.168228e-01 2.154296e-01 9 109090922 109091152 231 - 2.087 2.049 -0.127
ENSG00000106771 E022 33.5946321 0.0036902567 3.159900e-01 4.587581e-01 9 109091153 109091155 3 - 1.503 1.447 -0.192
ENSG00000106771 E023 102.1481704 0.0003259886 1.735417e-02 4.572213e-02 9 109093475 109093591 117 - 1.983 1.905 -0.262
ENSG00000106771 E024 87.3511161 0.0006167772 3.676407e-01 5.120004e-01 9 109106508 109106609 102 - 1.902 1.882 -0.069
ENSG00000106771 E025 67.1368591 0.0004101548 9.067989e-01 9.448135e-01 9 109108453 109108570 118 - 1.779 1.793 0.046
ENSG00000106771 E026 77.0256845 0.0059285853 1.183705e-03 4.586156e-03 9 109119335 109120111 777 - 1.883 1.698 -0.625