ENSG00000106733

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361092 ENSG00000106733 HEK293_OSMI2_2hA HEK293_TMG_2hB NMRK1 protein_coding protein_coding 3.842031 3.67222 4.64866 0.301289 0.2053586 0.339339 0.1999682 0.2194015 0.33608215 0.21940153 0.16854221 0.5932395 0.05980417 0.05573333 0.07243333 0.01670000 0.73294175 0.01376415 FALSE TRUE
ENST00000376808 ENSG00000106733 HEK293_OSMI2_2hA HEK293_TMG_2hB NMRK1 protein_coding protein_coding 3.842031 3.67222 4.64866 0.301289 0.2053586 0.339339 1.2284749 1.1316135 1.78371908 0.21657941 0.33723440 0.6518796 0.30016250 0.31006667 0.37993333 0.06986667 0.72666561 0.01376415 FALSE TRUE
ENST00000376811 ENSG00000106733 HEK293_OSMI2_2hA HEK293_TMG_2hB NMRK1 protein_coding protein_coding 3.842031 3.67222 4.64866 0.301289 0.2053586 0.339339 0.6270846 0.3766883 0.98851075 0.06104851 0.18303322 1.3686068 0.15650000 0.10393333 0.21123333 0.10730000 0.12783533 0.01376415 FALSE TRUE
ENST00000482537 ENSG00000106733 HEK293_OSMI2_2hA HEK293_TMG_2hB NMRK1 protein_coding processed_transcript 3.842031 3.67222 4.64866 0.301289 0.2053586 0.339339 0.2167673 0.1969724 0.05947263 0.07723356 0.05947263 -1.5749221 0.06082083 0.05823333 0.01180000 -0.04643333 0.27434499 0.01376415   FALSE
ENST00000490321 ENSG00000106733 HEK293_OSMI2_2hA HEK293_TMG_2hB NMRK1 protein_coding processed_transcript 3.842031 3.67222 4.64866 0.301289 0.2053586 0.339339 0.6544379 1.1295460 0.37304038 0.29893936 0.11467624 -1.5728908 0.18415833 0.29980000 0.08010000 -0.21970000 0.01376415 0.01376415   FALSE
ENST00000494066 ENSG00000106733 HEK293_OSMI2_2hA HEK293_TMG_2hB NMRK1 protein_coding nonsense_mediated_decay 3.842031 3.67222 4.64866 0.301289 0.2053586 0.339339 0.2397668 0.1100380 0.22725781 0.04873924 0.05800759 0.9829639 0.06669583 0.02926667 0.04873333 0.01946667 0.61128223 0.01376415 TRUE TRUE
MSTRG.32874.3 ENSG00000106733 HEK293_OSMI2_2hA HEK293_TMG_2hB NMRK1 protein_coding   3.842031 3.67222 4.64866 0.301289 0.2053586 0.339339 0.5985543 0.4825889 0.81424404 0.27108910 0.44536500 0.7426873 0.15243333 0.13473333 0.18156667 0.04683333 0.98034394 0.01376415 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106733 E001 0.0000000       9 75060573 75060576 4 -      
ENSG00000106733 E002 5.5864234 0.1455690075 0.6491294034 0.76047977 9 75060577 75061199 623 - 0.859 0.792 -0.263
ENSG00000106733 E003 1.1791501 0.0121497022 0.0736962721 0.14944378 9 75061200 75061201 2 - 0.463 0.143 -2.294
ENSG00000106733 E004 38.8346274 0.0043027350 0.2538173583 0.39042953 9 75061202 75061567 366 - 1.564 1.637 0.248
ENSG00000106733 E005 32.5431062 0.0090760918 0.4785236233 0.61693898 9 75066757 75066840 84 - 1.495 1.549 0.186
ENSG00000106733 E006 1.8338452 0.3395276369 0.2394000558 0.37342643 9 75066841 75067205 365 - 0.320 0.571 1.323
ENSG00000106733 E007 32.5112047 0.0011035478 0.4025100327 0.54625785 9 75068996 75069102 107 - 1.494 1.552 0.196
ENSG00000106733 E008 4.1601922 0.0098916189 0.8835004112 0.92947701 9 75069103 75069741 639 - 0.706 0.690 -0.067
ENSG00000106733 E009 18.8500491 0.0013932981 0.9557860926 0.97625452 9 75069742 75069813 72 - 1.296 1.302 0.020
ENSG00000106733 E010 1.5543008 0.0089779163 0.1483590027 0.25944476 9 75069814 75069894 81 - 0.502 0.250 -1.486
ENSG00000106733 E011 26.4736858 0.0007818602 0.0372093532 0.08586847 9 75069895 75070042 148 - 1.491 1.365 -0.434
ENSG00000106733 E012 18.4227567 0.0078441023 0.0237608854 0.05932455 9 75077159 75077207 49 - 1.368 1.185 -0.640
ENSG00000106733 E013 21.7824899 0.0126633144 0.0248228102 0.06151139 9 75077490 75077580 91 - 1.438 1.262 -0.611
ENSG00000106733 E014 8.4695008 0.0022032894 0.0340340395 0.07982570 9 75078326 75078582 257 - 1.065 0.835 -0.864
ENSG00000106733 E015 0.4031496 0.0295517078 0.1225730340 0.22362163 9 75082709 75083086 378 - 0.000 0.250 10.267
ENSG00000106733 E016 19.7959201 0.0466263739 0.9598192562 0.97873294 9 75083087 75083150 64 - 1.313 1.337 0.083
ENSG00000106733 E017 2.1400826 0.0085140576 0.0206308578 0.05280838 9 75087544 75087650 107 - 0.259 0.654 2.101
ENSG00000106733 E018 8.5906357 0.0245342247 0.0005930276 0.00250820 9 75087651 75087868 218 - 0.706 1.157 1.708
ENSG00000106733 E019 21.0052911 0.0272696934 0.2072590413 0.33522841 9 75088008 75088217 210 - 1.277 1.423 0.505