ENSG00000106723

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375859 ENSG00000106723 HEK293_OSMI2_2hA HEK293_TMG_2hB SPIN1 protein_coding protein_coding 19.67699 9.135131 32.25643 1.57655 0.6717935 1.818958 8.941901 3.014134 16.304716 0.1330503 0.9819080 2.4315801 0.42381667 0.34803333 0.50480000 0.15676667 0.138527506 0.0008988892 FALSE TRUE
ENST00000485565 ENSG00000106723 HEK293_OSMI2_2hA HEK293_TMG_2hB SPIN1 protein_coding processed_transcript 19.67699 9.135131 32.25643 1.57655 0.6717935 1.818958 3.499696 2.370880 3.396136 0.5776284 0.1609466 0.5166412 0.20498333 0.25706667 0.10523333 -0.15183333 0.001774181 0.0008988892 FALSE TRUE
ENST00000485804 ENSG00000106723 HEK293_OSMI2_2hA HEK293_TMG_2hB SPIN1 protein_coding processed_transcript 19.67699 9.135131 32.25643 1.57655 0.6717935 1.818958 2.203265 1.929426 4.037184 1.0370138 0.4664966 1.0612884 0.13060417 0.18890000 0.12536667 -0.06353333 0.783686449 0.0008988892 FALSE TRUE
MSTRG.32951.6 ENSG00000106723 HEK293_OSMI2_2hA HEK293_TMG_2hB SPIN1 protein_coding   19.67699 9.135131 32.25643 1.57655 0.6717935 1.818958 1.483657 0.807951 2.811376 0.4497025 0.1156539 1.7863127 0.07107917 0.09363333 0.08713333 -0.00650000 0.848991964 0.0008988892 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106723 E001 1.4038295 0.0092703787 5.018018e-01 6.379426e-01 9 88387640 88387676 37 + 0.273 0.502 1.317
ENSG00000106723 E002 1.9509965 0.0774575061 1.858758e-01 3.085989e-01 9 88388236 88388266 31 + 0.439 0.237 -1.265
ENSG00000106723 E003 0.2903454 0.3482390961 1.000000e+00   9 88388403 88388406 4 + 0.111 0.000 -19.352
ENSG00000106723 E004 0.4418608 0.0256398016 5.125388e-01 6.474472e-01 9 88388407 88388411 5 + 0.158 0.000 -19.746
ENSG00000106723 E005 0.8148214 0.0225236044 9.122197e-01 9.483679e-01 9 88388412 88388415 4 + 0.199 0.237 0.320
ENSG00000106723 E006 4.4530865 0.0144232233 2.365461e-02 5.909737e-02 9 88388416 88388429 14 + 0.693 0.390 -1.435
ENSG00000106723 E007 4.9796388 0.2268606780 2.031487e-01 3.301654e-01 9 88388430 88388430 1 + 0.720 0.515 -0.901
ENSG00000106723 E008 6.6718392 0.2396330911 1.488892e-01 2.601678e-01 9 88388431 88388439 9 + 0.826 0.610 -0.892
ENSG00000106723 E009 10.7113058 0.0109234537 2.897692e-03 9.963044e-03 9 88388440 88388443 4 + 1.014 0.730 -1.094
ENSG00000106723 E010 15.8742593 0.0011822330 9.500636e-04 3.788077e-03 9 88388444 88388451 8 + 1.163 0.954 -0.762
ENSG00000106723 E011 56.6843479 0.0004421877 3.855668e-07 3.486443e-06 9 88388452 88388538 87 + 1.686 1.555 -0.446
ENSG00000106723 E012 0.4482035 0.0268353673 5.123933e-01 6.472935e-01 9 88389317 88389370 54 + 0.158 0.000 -19.749
ENSG00000106723 E013 0.7406253 0.0153779689 2.303059e-01 3.628248e-01 9 88389371 88389410 40 + 0.238 0.000 -20.450
ENSG00000106723 E014 7.2322829 0.0630359338 3.207132e-02 7.599520e-02 9 88415607 88415699 93 + 0.870 0.593 -1.137
ENSG00000106723 E015 4.6298415 0.1213840283 8.857504e-01 9.309350e-01 9 88416644 88416766 123 + 0.638 0.784 0.605
ENSG00000106723 E016 5.9161731 0.0027201379 6.684118e-01 7.754307e-01 9 88418778 88418849 72 + 0.706 0.917 0.832
ENSG00000106723 E017 15.4205814 0.0011659571 3.200633e-02 7.586965e-02 9 88418850 88418951 102 + 1.136 1.075 -0.219
ENSG00000106723 E018 133.6527150 0.0002414587 2.989085e-09 4.055817e-08 9 88426382 88426591 210 + 2.040 1.993 -0.158
ENSG00000106723 E019 91.0380279 0.0002981829 2.428202e-08 2.784598e-07 9 88448941 88448989 49 + 1.881 1.798 -0.282
ENSG00000106723 E020 111.5493670 0.0002715482 5.511624e-06 3.885827e-05 9 88462496 88462631 136 + 1.956 1.949 -0.024
ENSG00000106723 E021 116.5352401 0.0003036885 2.110442e-12 4.909946e-11 9 88462632 88462749 118 + 1.993 1.876 -0.396
ENSG00000106723 E022 259.1445774 0.0011225783 5.388646e-14 1.591997e-12 9 88468372 88468605 234 + 2.327 2.269 -0.193
ENSG00000106723 E023 1863.4235540 0.0056290985 4.053979e-15 1.413350e-13 9 88475078 88478694 3617 + 3.106 3.366 0.865