ENSG00000106692

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000223528 ENSG00000106692 HEK293_OSMI2_2hA HEK293_TMG_2hB FKTN protein_coding protein_coding 6.188524 1.305871 10.00209 0.06521691 0.2419856 2.927652 1.1824549 0.3023434 1.182874 0.3023434 0.6187257 1.933236 0.2429750 0.2421333 0.1212333 -0.12090000 0.8409767794 0.0001062451 FALSE TRUE
ENST00000357998 ENSG00000106692 HEK293_OSMI2_2hA HEK293_TMG_2hB FKTN protein_coding protein_coding 6.188524 1.305871 10.00209 0.06521691 0.2419856 2.927652 2.6316919 0.7065612 4.615119 0.3718576 0.5141996 2.690329 0.3863208 0.5248333 0.4600667 -0.06476667 0.9436203429 0.0001062451 FALSE TRUE
ENST00000479846 ENSG00000106692 HEK293_OSMI2_2hA HEK293_TMG_2hB FKTN protein_coding processed_transcript 6.188524 1.305871 10.00209 0.06521691 0.2419856 2.927652 0.4377915 0.0000000 1.109902 0.0000000 0.1176393 6.807229 0.0521000 0.0000000 0.1106667 0.11066667 0.0001062451 0.0001062451   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106692 E001 0.1451727 0.0429918505 8.954421e-01   9 105558122 105558128 7 + 0.050 0.000 -9.089
ENSG00000106692 E002 0.3268771 0.0282086846 1.843734e-01   9 105558129 105558129 1 + 0.050 0.271 2.823
ENSG00000106692 E003 0.4741261 0.0208084209 3.582122e-01 5.025789e-01 9 105558130 105558130 1 + 0.095 0.271 1.823
ENSG00000106692 E004 0.4741261 0.0208084209 3.582122e-01 5.025789e-01 9 105558131 105558131 1 + 0.095 0.271 1.823
ENSG00000106692 E005 0.6192988 0.0199262529 5.311837e-01 6.636723e-01 9 105558132 105558137 6 + 0.136 0.271 1.238
ENSG00000106692 E006 0.6192988 0.0199262529 5.311837e-01 6.636723e-01 9 105558138 105558140 3 + 0.136 0.271 1.238
ENSG00000106692 E007 1.5330956 0.2362632482 6.564272e-01 7.659975e-01 9 105558141 105558142 2 + 0.295 0.438 0.836
ENSG00000106692 E008 3.5991896 0.0113888213 4.147432e-01 5.581418e-01 9 105558143 105558149 7 + 0.567 0.436 -0.636
ENSG00000106692 E009 8.5438170 0.0063217905 9.233733e-01 9.557003e-01 9 105558150 105558165 16 + 0.837 0.899 0.239
ENSG00000106692 E010 2.3563256 0.0070319387 5.830630e-02 1.237212e-01 9 105558166 105558274 109 + 0.471 0.000 -14.424
ENSG00000106692 E011 2.4930792 0.0558080038 6.241757e-02 1.307159e-01 9 105558275 105558305 31 + 0.488 0.000 -14.330
ENSG00000106692 E012 3.6044751 0.0110812738 1.227333e-01 2.238579e-01 9 105558306 105558411 106 + 0.581 0.271 -1.699
ENSG00000106692 E013 2.3616216 0.0118440243 9.626559e-01 9.804012e-01 9 105558412 105558595 184 + 0.413 0.437 0.125
ENSG00000106692 E014 1.0330470 0.0118459659 3.319426e-01 4.755732e-01 9 105558596 105559109 514 + 0.269 0.000 -13.509
ENSG00000106692 E015 0.1472490 0.0430005791 8.979167e-01   9 105570569 105570750 182 + 0.050 0.000 -10.828
ENSG00000106692 E016 1.7862439 0.0918792136 1.476500e-01 2.584960e-01 9 105570751 105570815 65 + 0.393 0.000 -13.869
ENSG00000106692 E017 1.9314166 0.0185994661 1.026506e-01 1.945463e-01 9 105570816 105570897 82 + 0.413 0.000 -14.160
ENSG00000106692 E018 0.0000000       9 105573653 105573654 2 +      
ENSG00000106692 E019 15.7285211 0.0012683003 1.938534e-01 3.186258e-01 9 105573655 105573746 92 + 1.097 0.985 -0.410
ENSG00000106692 E020 3.6644151 0.0044590631 4.096157e-01 5.532181e-01 9 105574198 105574239 42 + 0.567 0.436 -0.636
ENSG00000106692 E021 3.3719933 0.0065485119 5.026460e-01 6.386896e-01 9 105574240 105574278 39 + 0.537 0.436 -0.499
ENSG00000106692 E022 3.8514300 0.0265382794 7.592778e-01 8.436633e-01 9 105574279 105574332 54 + 0.553 0.650 0.431
ENSG00000106692 E023 16.9813854 0.0485407073 8.712919e-01 9.212209e-01 9 105574945 105575000 56 + 1.105 1.150 0.163
ENSG00000106692 E024 14.2138580 0.0838370568 5.739235e-01 6.998281e-01 9 105575001 105575004 4 + 1.043 1.028 -0.052
ENSG00000106692 E025 14.5021270 0.0737835594 5.408026e-01 6.718963e-01 9 105575005 105575006 2 + 1.052 1.028 -0.089
ENSG00000106692 E026 27.0172659 0.0089828093 3.510460e-01 4.952497e-01 9 105575007 105575119 113 + 1.308 1.264 -0.155
ENSG00000106692 E027 15.3043546 0.0038335389 6.644957e-02 1.374729e-01 9 105575120 105575137 18 + 1.097 0.899 -0.732
ENSG00000106692 E028 21.3728895 0.0109609031 2.075461e-02 5.306993e-02 9 105596598 105596636 39 + 1.234 0.986 -0.895
ENSG00000106692 E029 16.6633362 0.0082512665 6.407832e-03 1.968165e-02 9 105596637 105596657 21 + 1.141 0.793 -1.304
ENSG00000106692 E030 12.0009588 0.0066449389 9.422015e-02 1.817284e-01 9 105596658 105598085 1428 + 0.997 0.792 -0.781
ENSG00000106692 E031 2.9693954 0.0595945749 2.425801e-01 3.771868e-01 9 105598086 105598183 98 + 0.521 0.271 -1.421
ENSG00000106692 E032 2.9820809 0.0054017090 2.007922e-01 3.271848e-01 9 105598184 105598505 322 + 0.522 0.271 -1.425
ENSG00000106692 E033 1.7567204 0.0844920996 1.503188e-01 2.621122e-01 9 105598506 105598630 125 + 0.392 0.000 -13.880
ENSG00000106692 E034 2.0576749 0.0321245261 9.149608e-02 1.774636e-01 9 105598631 105598701 71 + 0.433 0.000 -14.189
ENSG00000106692 E035 3.7072789 0.0043835848 1.244310e-02 3.460167e-02 9 105598702 105599003 302 + 0.608 0.000 -14.861
ENSG00000106692 E036 8.0956153 0.2134786620 7.391889e-01 8.288819e-01 9 105599931 105600917 987 + 0.823 0.809 -0.054
ENSG00000106692 E037 2.1296810 0.0202474607 4.492624e-01 5.904651e-01 9 105600918 105601041 124 + 0.413 0.271 -0.875
ENSG00000106692 E038 1.3233924 0.0112822504 2.173591e-01 3.472084e-01 9 105601042 105601144 103 + 0.322 0.000 -13.796
ENSG00000106692 E039 33.7470404 0.0015403249 1.191213e-04 6.098742e-04 9 105601145 105601348 204 + 1.430 1.088 -1.204
ENSG00000106692 E040 1.2210941 0.0107178549 9.521770e-01 9.740544e-01 9 105603699 105603816 118 + 0.269 0.271 0.015
ENSG00000106692 E041 0.4407149 0.0229402601 3.585581e-01 5.029711e-01 9 105603864 105603947 84 + 0.095 0.271 1.821
ENSG00000106692 E042 48.0694203 0.0020961981 1.596133e-01 2.746013e-01 9 105604215 105604492 278 + 1.549 1.496 -0.182
ENSG00000106692 E043 40.0682164 0.0006202212 1.346669e-03 5.132111e-03 9 105607819 105607951 133 + 1.491 1.263 -0.792
ENSG00000106692 E044 1.9165531 0.0093379506 8.735718e-01 9.227604e-01 9 105607952 105609991 2040 + 0.370 0.436 0.362
ENSG00000106692 E045 11.0720360 0.0015902102 1.922431e-02 4.982267e-02 9 105615278 105615280 3 + 0.981 0.650 -1.307
ENSG00000106692 E046 30.1099959 0.0007139021 4.662731e-03 1.499245e-02 9 105615281 105615407 127 + 1.376 1.146 -0.810
ENSG00000106692 E047 26.6933248 0.0007250197 1.426507e-01 2.516411e-01 9 105617959 105618092 134 + 1.311 1.220 -0.321
ENSG00000106692 E048 2.9215997 0.0052862218 6.693140e-01 7.761495e-01 9 105619906 105619933 28 + 0.489 0.436 -0.264
ENSG00000106692 E049 27.8152306 0.0007341618 9.091915e-02 1.765967e-01 9 105619934 105620043 110 + 1.331 1.219 -0.392
ENSG00000106692 E050 15.7724175 0.0011400987 4.362893e-02 9.769940e-02 9 105620044 105620061 18 + 1.114 0.899 -0.793
ENSG00000106692 E051 1.2157955 0.0109168528 4.048621e-01 5.485466e-01 9 105620062 105620092 31 + 0.239 0.436 1.237
ENSG00000106692 E052 1.3350311 0.0427851636 4.061194e-01 5.497684e-01 9 105620093 105622823 2731 + 0.239 0.438 1.246
ENSG00000106692 E053 2.5560260 0.0059853635 8.026124e-01 8.742693e-01 9 105623050 105623221 172 + 0.453 0.436 -0.085
ENSG00000106692 E054 0.5911862 0.0185093142 7.383893e-01 8.282746e-01 9 105624282 105624396 115 + 0.173 0.000 -12.799
ENSG00000106692 E055 0.1472490 0.0430005791 8.979167e-01   9 105633356 105633474 119 + 0.050 0.000 -10.828
ENSG00000106692 E056 27.7125045 0.0007267861 3.814376e-03 1.262134e-02 9 105635051 105635148 98 + 1.341 1.088 -0.895
ENSG00000106692 E057 156.1607037 0.0009062510 1.567048e-07 1.533037e-06 9 105635149 105636672 1524 + 2.068 1.892 -0.588
ENSG00000106692 E058 390.9940984 0.0008348899 1.573738e-08 1.869685e-07 9 105636673 105640100 3428 + 2.414 2.584 0.569
ENSG00000106692 E059 94.5208969 0.0314715203 1.041431e-08 1.279171e-07 9 105640101 105641118 1018 + 1.694 2.249 1.867
ENSG00000106692 E060 0.5933762 0.0225989821 7.408233e-01 8.301475e-01 9 105644704 105645464 761 + 0.173 0.000 -12.774
ENSG00000106692 E061 0.4439371 0.0215808033 1.000000e+00 1.000000e+00 9 105645465 105645514 50 + 0.136 0.000 -12.417
ENSG00000106692 E062 2.0495314 0.1451531404 3.981442e-01 5.418934e-01 9 105652072 105653820 1749 + 0.348 0.557 1.084