ENSG00000106682

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265753 ENSG00000106682 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF4H protein_coding protein_coding 261.3299 316.3488 268.3013 11.06976 4.237804 -0.237654 88.91894 97.53413 96.22656 6.304153 3.080360 -0.01946989 0.3440792 0.3077 0.3585333 0.05083333 0.050739975 6.632844e-25 FALSE TRUE
ENST00000353999 ENSG00000106682 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF4H protein_coding protein_coding 261.3299 316.3488 268.3013 11.06976 4.237804 -0.237654 161.20580 211.39329 159.25181 5.014002 2.811869 -0.40859746 0.6104042 0.6688 0.5936333 -0.07516667 0.001999882 6.632844e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106682 E001 0.4460135 2.909730e-02 5.335389e-02 1.151196e-01 7 74174175 74174230 56 + 0.318 0.000 -12.932
ENSG00000106682 E002 0.6277178 1.971208e-02 2.106982e-01 3.393739e-01 7 74174231 74174269 39 + 0.318 0.112 -1.869
ENSG00000106682 E003 11.5189060 1.590510e-02 7.503072e-01 8.370192e-01 7 74174270 74174330 61 + 1.057 1.116 0.213
ENSG00000106682 E004 18.4664164 6.931176e-03 7.365101e-01 8.269844e-01 7 74174331 74174352 22 + 1.252 1.304 0.183
ENSG00000106682 E005 26.0179026 1.084393e-02 4.867329e-01 6.244546e-01 7 74174353 74174355 3 + 1.446 1.411 -0.121
ENSG00000106682 E006 30.5297696 1.713330e-02 9.739656e-01 9.877563e-01 7 74174356 74174357 2 + 1.478 1.498 0.069
ENSG00000106682 E007 30.5297696 1.713330e-02 9.739656e-01 9.877563e-01 7 74174358 74174358 1 + 1.478 1.498 0.069
ENSG00000106682 E008 1065.2129274 1.343803e-03 1.570719e-08 1.866449e-07 7 74174359 74174442 84 + 3.074 2.979 -0.315
ENSG00000106682 E009 0.8417882 1.499474e-02 8.669926e-01 9.184088e-01 7 74178656 74178826 171 + 0.235 0.275 0.302
ENSG00000106682 E010 0.2965864 1.195090e-01 3.091410e-01   7 74179338 74179418 81 + 0.000 0.199 12.161
ENSG00000106682 E011 0.4448795 3.716232e-01 2.706338e-01 4.092624e-01 7 74183822 74183921 100 + 0.000 0.266 12.394
ENSG00000106682 E012 2219.7368728 7.988349e-04 3.369263e-11 6.433794e-10 7 74187611 74187798 188 + 3.383 3.306 -0.254
ENSG00000106682 E013 1521.2938174 4.176124e-04 5.322562e-08 5.704590e-07 7 74189673 74189737 65 + 3.203 3.155 -0.160
ENSG00000106682 E014 0.7490443 9.489801e-02 1.265864e-02 3.510724e-02 7 74189738 74189821 84 + 0.447 0.000 -14.497
ENSG00000106682 E015 1866.6501228 2.967598e-04 9.579627e-09 1.185854e-07 7 74189822 74189918 97 + 3.289 3.247 -0.138
ENSG00000106682 E016 25.3286065 7.867336e-04 9.651042e-12 2.016723e-10 7 74189919 74190246 328 + 1.623 1.172 -1.562
ENSG00000106682 E017 605.9860370 4.428613e-04 3.579749e-12 8.017174e-11 7 74190247 74190306 60 + 2.833 2.736 -0.322
ENSG00000106682 E018 257.5502253 5.360112e-04 5.331175e-22 4.247162e-20 7 74192702 74194740 2039 + 2.518 2.307 -0.706
ENSG00000106682 E019 2461.7968076 6.611625e-05 1.233574e-10 2.145190e-09 7 74194741 74194878 138 + 3.401 3.376 -0.083
ENSG00000106682 E020 4.5089868 7.911684e-02 4.629273e-01 6.027794e-01 7 74194879 74195059 181 + 0.627 0.783 0.649
ENSG00000106682 E021 19.8086113 2.721105e-02 1.289001e-03 4.939568e-03 7 74195060 74195168 109 + 1.474 1.139 -1.172
ENSG00000106682 E022 1163.5750587 8.189410e-04 8.672406e-03 2.546556e-02 7 74195169 74195170 2 + 3.072 3.050 -0.073
ENSG00000106682 E023 5268.4598519 1.694780e-04 7.793237e-02 1.561582e-01 7 74195171 74195856 686 + 3.694 3.728 0.115
ENSG00000106682 E024 6298.8795971 3.323532e-04 3.841953e-33 8.141459e-31 7 74195857 74196641 785 + 3.718 3.836 0.393
ENSG00000106682 E025 2125.9955463 3.389008e-03 5.141712e-06 3.649067e-05 7 74196642 74197192 551 + 3.223 3.375 0.506