ENSG00000106665

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000223398 ENSG00000106665 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP2 protein_coding protein_coding 2.203682 4.209821 1.181516 0.1991869 0.08161257 -1.824384 0.2593632 0.3164292 0.1501645 0.02869437 0.04614947 -1.0272159 0.11301250 0.07586667 0.1319667 0.0561000 6.145422e-01 2.371436e-06 FALSE TRUE
ENST00000361545 ENSG00000106665 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP2 protein_coding protein_coding 2.203682 4.209821 1.181516 0.1991869 0.08161257 -1.824384 1.2923814 1.9573308 0.9774443 0.35612506 0.10611295 -0.9944683 0.66510833 0.45923333 0.8224000 0.3631667 2.103594e-03 2.371436e-06 FALSE TRUE
ENST00000487091 ENSG00000106665 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP2 protein_coding retained_intron 2.203682 4.209821 1.181516 0.1991869 0.08161257 -1.824384 0.0867137 0.3432172 0.0000000 0.11427835 0.00000000 -5.1424837 0.03692083 0.07940000 0.0000000 -0.0794000 2.238770e-02 2.371436e-06 FALSE TRUE
ENST00000487447 ENSG00000106665 HEK293_OSMI2_2hA HEK293_TMG_2hB CLIP2 protein_coding protein_coding 2.203682 4.209821 1.181516 0.1991869 0.08161257 -1.824384 0.4537813 1.4108886 0.0000000 0.26103671 0.00000000 -7.1506497 0.13683333 0.34170000 0.0000000 -0.3417000 2.371436e-06 2.371436e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106665 E001 1.0351338 0.0329063317 0.216715875 0.34644512 7 74289407 74289474 68 + 0.421 0.200 -1.482
ENSG00000106665 E002 6.6657584 0.0392303264 0.066680563 0.13787102 7 74289475 74289734 260 + 0.988 0.730 -0.998
ENSG00000106665 E003 12.9846030 0.0692195721 0.200235051 0.32652122 7 74317480 74317667 188 + 1.181 1.024 -0.567
ENSG00000106665 E004 29.4395766 0.0008601345 0.009388220 0.02725152 7 74338448 74339004 557 + 1.520 1.354 -0.572
ENSG00000106665 E005 13.3753209 0.0023019189 0.043723652 0.09788144 7 74353880 74354004 125 + 1.211 1.023 -0.676
ENSG00000106665 E006 17.9014096 0.0012031437 0.117873529 0.21688166 7 74356410 74356623 214 + 1.290 1.165 -0.443
ENSG00000106665 E007 18.1790902 0.0132234483 0.779565593 0.85827239 7 74357280 74357477 198 + 1.211 1.198 -0.046
ENSG00000106665 E008 12.7667955 0.0332172745 0.298969998 0.44046169 7 74360175 74360278 104 + 1.148 1.035 -0.407
ENSG00000106665 E009 9.0059437 0.0020227033 0.683356984 0.78656508 7 74364255 74364315 61 + 0.962 0.924 -0.145
ENSG00000106665 E010 1.6584824 0.0314341480 0.678263622 0.78278064 7 74372932 74373036 105 + 0.320 0.406 0.508
ENSG00000106665 E011 21.2196719 0.0011960922 0.285172075 0.42547741 7 74375887 74376069 183 + 1.325 1.249 -0.268
ENSG00000106665 E012 53.7465630 0.0048410228 0.870000720 0.92036554 7 74376070 74376694 625 + 1.649 1.655 0.022
ENSG00000106665 E013 20.5446832 0.0010587068 0.217901832 0.34790066 7 74376695 74376822 128 + 1.165 1.285 0.425
ENSG00000106665 E014 2.7604361 0.0058591076 0.055499109 0.11883875 7 74380024 74380805 782 + 0.189 0.571 2.323
ENSG00000106665 E015 13.8394365 0.0014093694 0.134643202 0.24060965 7 74380806 74380863 58 + 0.962 1.135 0.629
ENSG00000106665 E016 0.9545924 0.0136968632 0.173711082 0.29301188 7 74380864 74381041 178 + 0.000 0.295 10.857
ENSG00000106665 E017 0.0000000       7 74381582 74381630 49 +      
ENSG00000106665 E018 0.1451727 0.0431680272 0.162931294   7 74386384 74386520 137 + 0.189 0.000 -11.362
ENSG00000106665 E019 14.3781964 0.0015121182 0.495706813 0.63247263 7 74386521 74386597 77 + 1.055 1.135 0.288
ENSG00000106665 E020 8.0437715 0.0034204655 0.154131612 0.26728214 7 74386598 74386604 7 + 0.729 0.933 0.798
ENSG00000106665 E021 0.0000000       7 74388670 74389102 433 +      
ENSG00000106665 E022 20.7293474 0.0018831971 0.797822474 0.87099252 7 74389103 74389259 157 + 1.239 1.272 0.115
ENSG00000106665 E023 0.1482932 0.0428199304 1.000000000   7 74389260 74389432 173 + 0.000 0.077 8.587
ENSG00000106665 E024 20.6125923 0.0009971228 0.328201028 0.47168596 7 74397074 74397233 160 + 1.314 1.244 -0.247
ENSG00000106665 E025 17.0858053 0.0011497264 0.942229888 0.96773518 7 74400370 74400481 112 + 1.165 1.182 0.061
ENSG00000106665 E026 13.0979350 0.0015287690 0.723649065 0.81741731 7 74400482 74400555 74 + 1.095 1.068 -0.097
ENSG00000106665 E027 11.4178811 0.0023639628 0.879187755 0.92640612 7 74401505 74401567 63 + 0.987 1.015 0.101
ENSG00000106665 E028 153.1318249 0.0073485826 0.009940472 0.02861256 7 74403837 74405935 2099 + 2.012 2.136 0.415