ENSG00000106638

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305632 ENSG00000106638 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL2 protein_coding protein_coding 58.04917 70.18326 53.22828 3.058241 1.893339 -0.3988685 5.9842580 7.152614 5.1496328 0.5032212 0.1549479 -0.4732177 0.1034625 0.1017000 0.09676667 -0.004933333 8.353117e-01 9.321284e-24 FALSE  
ENST00000417008 ENSG00000106638 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL2 protein_coding nonsense_mediated_decay 58.04917 70.18326 53.22828 3.058241 1.893339 -0.3988685 0.8576134 0.000000 3.7211208 0.0000000 0.5807148 8.5434652 0.0155375 0.0000000 0.07026667 0.070266667 9.321284e-24 9.321284e-24 FALSE  
ENST00000424598 ENSG00000106638 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL2 protein_coding nonsense_mediated_decay 58.04917 70.18326 53.22828 3.058241 1.893339 -0.3988685 12.6432921 14.791023 8.5477815 2.6164701 0.8342520 -0.7903882 0.2179917 0.2083000 0.16183333 -0.046466667 6.054574e-01 9.321284e-24 FALSE  
ENST00000450285 ENSG00000106638 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL2 protein_coding nonsense_mediated_decay 58.04917 70.18326 53.22828 3.058241 1.893339 -0.3988685 27.0855951 34.486319 24.6539257 0.4863584 1.2608417 -0.4840400 0.4651292 0.4928333 0.46436667 -0.028466667 7.891022e-01 9.321284e-24 FALSE  
ENST00000459913 ENSG00000106638 HEK293_OSMI2_2hA HEK293_TMG_2hB TBL2 protein_coding processed_transcript 58.04917 70.18326 53.22828 3.058241 1.893339 -0.3988685 1.6137311 3.891980 0.3053468 0.9343058 0.3053468 -3.6291953 0.0273500 0.0567000 0.00550000 -0.051200000 5.712504e-02 9.321284e-24 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106638 E001 330.204349 0.0001651319 0.470895984 0.6100776970 7 73567537 73569659 2123 - 2.484 2.513 0.095
ENSG00000106638 E002 737.151506 0.0021018759 0.000015953 0.0001012072 7 73569660 73570007 348 - 2.766 2.887 0.404
ENSG00000106638 E003 812.436876 0.0022712638 0.014321985 0.0389617777 7 73570008 73570194 187 - 2.841 2.914 0.243
ENSG00000106638 E004 784.723256 0.0032537132 0.127790584 0.2310964072 7 73570195 73570410 216 - 2.838 2.893 0.181
ENSG00000106638 E005 281.422631 0.0007162049 0.001749552 0.0064389438 7 73570411 73570470 60 - 2.369 2.461 0.307
ENSG00000106638 E006 166.239574 0.0023539533 0.005715638 0.0178593195 7 73570471 73570483 13 - 2.124 2.239 0.383
ENSG00000106638 E007 736.062729 0.0018036091 0.132421944 0.2374420529 7 73570484 73570885 402 - 2.816 2.863 0.154
ENSG00000106638 E008 406.573751 0.0005965638 0.183158895 0.3051526099 7 73570886 73570972 87 - 2.601 2.586 -0.050
ENSG00000106638 E009 465.839411 0.0001317346 0.036590800 0.0846958599 7 73571189 73571312 124 - 2.665 2.642 -0.075
ENSG00000106638 E010 210.445656 0.0002411700 0.198789879 0.3246816238 7 73571313 73571341 29 - 2.319 2.299 -0.066
ENSG00000106638 E011 13.825279 0.0012428125 0.869572063 0.9201483958 7 73571342 73571394 53 - 1.158 1.156 -0.008
ENSG00000106638 E012 28.657065 0.0006782101 0.130298947 0.2345818368 7 73571584 73571981 398 - 1.375 1.492 0.402
ENSG00000106638 E013 14.293513 0.0027854716 0.666449599 0.7738794053 7 73571982 73572035 54 - 1.133 1.186 0.190
ENSG00000106638 E014 172.093310 0.0023785657 0.089173985 0.1738683460 7 73572844 73572847 4 - 2.251 2.204 -0.158
ENSG00000106638 E015 286.791319 0.0012377286 0.015557177 0.0417512227 7 73572848 73572877 30 - 2.474 2.423 -0.171
ENSG00000106638 E016 377.236173 0.0001306488 0.012376364 0.0344373220 7 73572878 73572945 68 - 2.581 2.547 -0.113
ENSG00000106638 E017 272.527188 0.0001551032 0.031645854 0.0751609360 7 73572946 73572970 25 - 2.440 2.405 -0.115
ENSG00000106638 E018 12.194038 0.0016562844 0.870502167 0.9207095201 7 73572971 73573319 349 - 1.077 1.106 0.102
ENSG00000106638 E019 209.044684 0.0001782149 0.113471552 0.2105882154 7 73573320 73573320 1 - 2.321 2.294 -0.089
ENSG00000106638 E020 235.874480 0.0002113233 0.067243637 0.1387732329 7 73573321 73573340 20 - 2.375 2.344 -0.103
ENSG00000106638 E021 199.832258 0.0004872252 0.169117437 0.2870396444 7 73573341 73573342 2 - 2.299 2.274 -0.083
ENSG00000106638 E022 358.242817 0.0001477450 0.003778386 0.0125212774 7 73573343 73573400 58 - 2.564 2.521 -0.143
ENSG00000106638 E023 337.443660 0.0001725641 0.060700476 0.1278136627 7 73573401 73573471 71 - 2.528 2.504 -0.081
ENSG00000106638 E024 6.827662 0.0027834697 0.001546591 0.0057863370 7 73573832 73573878 47 - 1.077 0.714 -1.391
ENSG00000106638 E025 7.345709 0.0028440058 0.001569697 0.0058612102 7 73573879 73573937 59 - 1.106 0.756 -1.325
ENSG00000106638 E026 212.567749 0.0002544150 0.075590512 0.1524516769 7 73573938 73573960 23 - 2.332 2.300 -0.107
ENSG00000106638 E027 329.746049 0.0020101556 0.822702677 0.8882195784 7 73573961 73574055 95 - 2.497 2.501 0.013
ENSG00000106638 E028 302.649662 0.0050957644 0.420804424 0.5639870661 7 73574056 73574122 67 - 2.478 2.453 -0.080
ENSG00000106638 E029 299.075617 0.0046675097 0.439984222 0.5817091855 7 73574383 73574444 62 - 2.471 2.449 -0.075
ENSG00000106638 E030 237.144978 0.0003627051 0.067674025 0.1394882168 7 73574445 73574476 32 - 2.377 2.345 -0.109
ENSG00000106638 E031 248.936723 0.0017929471 0.315552664 0.4583164447 7 73574477 73574513 37 - 2.389 2.369 -0.067
ENSG00000106638 E032 18.737070 0.0060605196 0.065606995 0.1360576362 7 73574514 73574571 58 - 1.146 1.325 0.634
ENSG00000106638 E033 30.828104 0.0079295323 0.129190161 0.2330545387 7 73574572 73574804 233 - 1.390 1.518 0.442
ENSG00000106638 E034 22.567597 0.0008651510 0.376988007 0.5213159819 7 73576541 73576701 161 - 1.382 1.330 -0.183
ENSG00000106638 E035 9.141549 0.0326639366 0.025782153 0.0634941582 7 73576702 73576748 47 - 0.737 1.072 1.275
ENSG00000106638 E036 13.339737 0.0069475551 0.458856979 0.5991022619 7 73577973 73578245 273 - 1.170 1.107 -0.227
ENSG00000106638 E037 4.572703 0.0035595869 0.532560780 0.6649095288 7 73578246 73578267 22 - 0.768 0.692 -0.313
ENSG00000106638 E038 3.464532 0.0046444044 0.203255521 0.3302980676 7 73578268 73578284 17 - 0.737 0.558 -0.773
ENSG00000106638 E039 3.284904 0.0047822507 0.140613144 0.2488648112 7 73578285 73578289 5 - 0.737 0.525 -0.925
ENSG00000106638 E040 4.751089 0.0034834625 0.046782785 0.1034341463 7 73578290 73578419 130 - 0.897 0.643 -1.023
ENSG00000106638 E041 290.859378 0.0039165367 0.064164630 0.1336330489 7 73578420 73578676 257 - 2.481 2.422 -0.197
ENSG00000106638 E042 0.000000       7 73578743 73578791 49 -