ENSG00000106636

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000223369 ENSG00000106636 HEK293_OSMI2_2hA HEK293_TMG_2hB YKT6 protein_coding protein_coding 104.4204 165.7608 69.33947 3.999545 0.1555276 -1.257233 93.87232 155.748 56.77382 3.767695 0.1767642 -1.455754 0.8821333 0.9396 0.8188 -0.1208 2.214728e-33 2.214728e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106636 E001 0.7696683 1.574559e-02 1.568693e-01 2.709260e-01 7 44200959 44200964 6 + 0.391 0.157 -1.748
ENSG00000106636 E002 0.7696683 1.574559e-02 1.568693e-01 2.709260e-01 7 44200965 44200965 1 + 0.391 0.157 -1.748
ENSG00000106636 E003 0.7696683 1.574559e-02 1.568693e-01 2.709260e-01 7 44200966 44200967 2 + 0.391 0.157 -1.748
ENSG00000106636 E004 2.6746143 5.379961e-02 8.439915e-01 9.028632e-01 7 44200968 44200971 4 + 0.536 0.530 -0.025
ENSG00000106636 E005 4.2749099 1.436523e-02 1.729552e-01 2.920386e-01 7 44200972 44200977 6 + 0.803 0.629 -0.716
ENSG00000106636 E006 7.6330930 4.587872e-02 3.843052e-02 8.815823e-02 7 44200978 44200982 5 + 1.069 0.796 -1.031
ENSG00000106636 E007 118.0579519 4.173512e-02 2.268672e-03 8.055499e-03 7 44200983 44201011 29 + 2.202 1.933 -0.899
ENSG00000106636 E008 702.4746540 7.216818e-03 1.796536e-03 6.588491e-03 7 44201012 44201239 228 + 2.862 2.768 -0.314
ENSG00000106636 E009 386.9024064 4.101448e-03 2.298703e-04 1.091325e-03 7 44204568 44204574 7 + 2.605 2.508 -0.322
ENSG00000106636 E010 695.3065054 2.865629e-03 2.717342e-04 1.264723e-03 7 44204575 44204650 76 + 2.841 2.771 -0.232
ENSG00000106636 E011 0.1451727 4.331886e-02 1.992255e-01   7 44205583 44205631 49 + 0.172 0.000 -9.583
ENSG00000106636 E012 530.5666063 3.463836e-04 1.802859e-06 1.416382e-05 7 44206385 44206406 22 + 2.711 2.659 -0.174
ENSG00000106636 E013 863.7149388 4.371480e-04 1.376058e-06 1.108895e-05 7 44206407 44206485 79 + 2.915 2.874 -0.137
ENSG00000106636 E014 23.7887251 7.905244e-04 2.262308e-20 1.509111e-18 7 44206486 44207332 847 + 1.692 1.075 -2.147
ENSG00000106636 E015 8.3794595 3.832234e-02 1.987606e-04 9.585226e-04 7 44207333 44207387 55 + 1.220 0.729 -1.842
ENSG00000106636 E016 1095.7228322 7.471203e-05 1.542374e-11 3.114786e-10 7 44207388 44207492 105 + 3.020 2.976 -0.144
ENSG00000106636 E017 657.5237033 1.240376e-04 1.811563e-14 5.745774e-13 7 44208133 44208135 3 + 2.824 2.743 -0.271
ENSG00000106636 E018 1009.8086947 1.397369e-04 1.644535e-14 5.255604e-13 7 44208136 44208198 63 + 2.997 2.935 -0.206
ENSG00000106636 E019 19.9812450 1.091540e-03 1.455214e-17 6.991779e-16 7 44208199 44208406 208 + 1.622 1.006 -2.162
ENSG00000106636 E020 40.0400015 1.716968e-03 1.421047e-22 1.207775e-20 7 44208407 44208794 388 + 1.878 1.352 -1.792
ENSG00000106636 E021 205.2146705 3.944180e-04 1.620330e-69 2.417060e-66 7 44208795 44210841 2047 + 2.528 2.103 -1.418
ENSG00000106636 E022 31.3654798 6.357036e-04 1.281725e-10 2.221988e-09 7 44210842 44210931 90 + 1.696 1.331 -1.252
ENSG00000106636 E023 31.5973583 3.500178e-03 2.069849e-08 2.406276e-07 7 44210932 44211022 91 + 1.688 1.348 -1.167
ENSG00000106636 E024 1107.4189996 1.233392e-04 5.656472e-05 3.144371e-04 7 44211023 44211124 102 + 3.003 2.990 -0.044
ENSG00000106636 E025 21.4227542 7.316881e-03 1.245486e-03 4.795024e-03 7 44211125 44211553 429 + 1.459 1.217 -0.841
ENSG00000106636 E026 35.2091039 7.707235e-03 5.068598e-01 6.424925e-01 7 44211554 44211604 51 + 1.514 1.498 -0.055
ENSG00000106636 E027 46.1028407 6.014155e-04 2.435444e-14 7.563729e-13 7 44211605 44212246 642 + 1.852 1.486 -1.244
ENSG00000106636 E028 880.8610190 8.166246e-05 1.305557e-01 2.349297e-01 7 44212247 44212287 41 + 2.882 2.898 0.054
ENSG00000106636 E029 3533.3835730 6.500510e-05 2.417195e-25 2.729024e-23 7 44212288 44213174 887 + 3.415 3.523 0.360
ENSG00000106636 E030 998.9113686 9.305245e-04 1.110483e-08 1.357451e-07 7 44213175 44213254 80 + 2.836 2.983 0.488
ENSG00000106636 E031 3841.4815917 2.843475e-03 1.363477e-17 6.578881e-16 7 44213255 44214294 1040 + 3.356 3.584 0.756