ENSG00000106617

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287878 ENSG00000106617 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKAG2 protein_coding protein_coding 6.579556 5.241626 9.055482 0.3776568 0.3950302 0.7876194 1.0504132 0.9866618 1.694643 0.22295024 0.11032111 0.774294 0.16926667 0.1957667 0.18713333 -0.008633333 1.0000000000 0.0005600846 FALSE TRUE
ENST00000418337 ENSG00000106617 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKAG2 protein_coding protein_coding 6.579556 5.241626 9.055482 0.3776568 0.3950302 0.7876194 3.3066205 2.4528822 5.007833 0.43508989 0.22316531 1.026717 0.47621667 0.4613000 0.55310000 0.091800000 0.4220562979 0.0005600846 FALSE TRUE
ENST00000474383 ENSG00000106617 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKAG2 protein_coding processed_transcript 6.579556 5.241626 9.055482 0.3776568 0.3950302 0.7876194 0.4538716 1.0490196 0.159083 0.08146094 0.09897744 -2.646926 0.09561667 0.2031667 0.01673333 -0.186433333 0.0005600846 0.0005600846   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106617 E001 0.1482932 0.0411597534 3.003424e-01   7 151556124 151556126 3 - 0.000 0.153 9.492
ENSG00000106617 E002 0.9201516 0.0135346332 5.531395e-01 6.823319e-01 7 151556127 151556160 34 - 0.244 0.355 0.748
ENSG00000106617 E003 8.4321562 0.0352066272 1.552802e-02 4.168800e-02 7 151556161 151556181 21 - 0.797 1.144 1.293
ENSG00000106617 E004 16.3601198 0.0385876396 2.726547e-01 4.116121e-01 7 151556182 151556200 19 - 1.171 1.325 0.543
ENSG00000106617 E005 16.7299600 0.0359442808 2.908308e-01 4.316155e-01 7 151556201 151556205 5 - 1.185 1.327 0.498
ENSG00000106617 E006 16.8782531 0.0383499440 2.770277e-01 4.165310e-01 7 151556206 151556208 3 - 1.185 1.334 0.524
ENSG00000106617 E007 16.8782531 0.0383499440 2.770277e-01 4.165310e-01 7 151556209 151556210 2 - 1.185 1.334 0.524
ENSG00000106617 E008 17.0265463 0.0408565224 2.653344e-01 4.033799e-01 7 151556211 151556214 4 - 1.185 1.342 0.549
ENSG00000106617 E009 17.0630780 0.0360457352 1.896918e-01 3.133691e-01 7 151556215 151556215 1 - 1.178 1.351 0.606
ENSG00000106617 E010 22.5435415 0.0304778710 1.793190e-01 3.002544e-01 7 151556216 151556283 68 - 1.298 1.462 0.567
ENSG00000106617 E011 42.2075548 0.0074627770 2.939402e-03 1.008569e-02 7 151556284 151556385 102 - 1.536 1.749 0.723
ENSG00000106617 E012 46.6873073 0.0040330147 2.421450e-04 1.142272e-03 7 151556386 151556503 118 - 1.570 1.792 0.755
ENSG00000106617 E013 92.6819708 0.0004113153 9.332446e-04 3.730438e-03 7 151556504 151556940 437 - 1.910 2.039 0.433
ENSG00000106617 E014 19.8349638 0.0010021939 9.594385e-01 9.785343e-01 7 151556941 151556945 5 - 1.313 1.327 0.049
ENSG00000106617 E015 26.1584526 0.0007871499 7.193381e-01 8.142129e-01 7 151556946 151556992 47 - 1.441 1.427 -0.048
ENSG00000106617 E016 23.1168282 0.0007991733 1.712256e-01 2.897845e-01 7 151556993 151557040 48 - 1.417 1.327 -0.309
ENSG00000106617 E017 77.7485586 0.0003506536 3.741249e-01 5.185414e-01 7 151557041 151557232 192 - 1.875 1.920 0.152
ENSG00000106617 E018 1.8487988 0.0078390371 1.117604e-01 2.081425e-01 7 151560375 151560523 149 - 0.545 0.266 -1.572
ENSG00000106617 E019 55.7905455 0.0004809718 5.684562e-02 1.211960e-01 7 151560524 151560617 94 - 1.709 1.808 0.334
ENSG00000106617 E020 0.6028395 0.3904465872 7.649113e-01 8.478393e-01 7 151560618 151561916 1299 - 0.245 0.150 -0.874
ENSG00000106617 E021 54.0987597 0.0004717745 5.521299e-01 6.814556e-01 7 151564078 151564194 117 - 1.748 1.730 -0.060
ENSG00000106617 E022 30.3618582 0.0049618511 2.225136e-01 3.533846e-01 7 151564195 151564224 30 - 1.523 1.447 -0.263
ENSG00000106617 E023 2.5279359 0.0752764596 9.706347e-01 9.856552e-01 7 151564225 151565345 1121 - 0.546 0.546 0.002
ENSG00000106617 E024 31.0008517 0.0079013530 2.043141e-01 3.315576e-01 7 151565346 151565383 38 - 1.536 1.447 -0.306
ENSG00000106617 E025 2.0851221 0.0104823251 5.987045e-04 2.528654e-03 7 151565384 151565719 336 - 0.655 0.000 -15.417
ENSG00000106617 E026 68.0446077 0.0004114343 8.030609e-03 2.385759e-02 7 151565720 151565885 166 - 1.877 1.772 -0.351
ENSG00000106617 E027 3.5920917 0.0047111170 7.488844e-02 1.513500e-01 7 151565886 151566572 687 - 0.761 0.492 -1.177
ENSG00000106617 E028 0.4439371 0.0216166104 1.982037e-01 3.239588e-01 7 151566573 151566613 41 - 0.244 0.000 -13.454
ENSG00000106617 E029 1.4038295 0.0096765512 7.784408e-01 8.574426e-01 7 151566614 151566699 86 - 0.399 0.355 -0.250
ENSG00000106617 E030 2.2948374 0.0064461044 3.653476e-01 5.096621e-01 7 151566700 151567334 635 - 0.575 0.429 -0.710
ENSG00000106617 E031 0.0000000       7 151568694 151568715 22 -      
ENSG00000106617 E032 55.0065669 0.0004655175 1.292573e-02 3.573711e-02 7 151568716 151568842 127 - 1.789 1.680 -0.369
ENSG00000106617 E033 30.8259957 0.0008560735 9.876297e-02 1.885991e-01 7 151570171 151570189 19 - 1.536 1.441 -0.328
ENSG00000106617 E034 26.5416581 0.0007593719 5.570425e-02 1.191870e-01 7 151570190 151570225 36 - 1.482 1.361 -0.420
ENSG00000106617 E035 3.7488792 0.3310913528 1.730141e-01 2.921109e-01 7 151571462 151572407 946 - 0.799 0.365 -2.005
ENSG00000106617 E036 1.0653123 0.0130635630 1.745968e-01 2.941750e-01 7 151572408 151572663 256 - 0.399 0.153 -1.834
ENSG00000106617 E037 27.1985342 0.0007199267 6.115840e-02 1.285778e-01 7 151572664 151572709 46 - 1.493 1.376 -0.402
ENSG00000106617 E038 1.1824861 0.0109693228 1.207179e-02 3.370686e-02 7 151573367 151574890 1524 - 0.478 0.000 -14.741
ENSG00000106617 E039 27.8408756 0.0008368118 5.540083e-02 1.186766e-01 7 151574891 151574949 59 - 1.503 1.384 -0.411
ENSG00000106617 E040 0.0000000       7 151576183 151576370 188 -      
ENSG00000106617 E041 34.0792360 0.0007823898 8.077040e-03 2.397598e-02 7 151576371 151576452 82 - 1.601 1.447 -0.527
ENSG00000106617 E042 0.0000000       7 151594966 151595344 379 -      
ENSG00000106617 E043 33.1893185 0.0006222525 2.023919e-06 1.572898e-05 7 151595345 151595451 107 - 1.632 1.336 -1.019
ENSG00000106617 E044 12.7982712 0.0014663178 8.034855e-06 5.453494e-05 7 151595452 151595454 3 - 1.274 0.812 -1.699
ENSG00000106617 E045 0.0000000       7 151606094 151606183 90 -      
ENSG00000106617 E046 0.0000000       7 151631638 151631768 131 -      
ENSG00000106617 E047 0.0000000       7 151631769 151632068 300 -      
ENSG00000106617 E048 21.8214935 0.0074908654 1.125268e-04 5.794947e-04 7 151632069 151632132 64 - 1.464 1.122 -1.196
ENSG00000106617 E049 12.3696529 0.0171963664 2.247286e-01 3.561089e-01 7 151632133 151632138 6 - 1.170 1.031 -0.500
ENSG00000106617 E050 7.4301162 0.0529601045 2.627024e-02 6.449144e-02 7 151632139 151632353 215 - 1.042 0.679 -1.406
ENSG00000106617 E051 0.2955422 0.0286143385 7.200993e-01   7 151632571 151633182 612 - 0.097 0.153 0.748
ENSG00000106617 E052 0.1451727 0.0433066616 8.025615e-01   7 151674939 151675419 481 - 0.097 0.000 -11.895
ENSG00000106617 E053 13.4260754 0.0452898289 9.663975e-01 9.829067e-01 7 151675420 151675547 128 - 1.147 1.144 -0.013
ENSG00000106617 E054 11.2011239 0.0050487246 5.826703e-01 7.069793e-01 7 151675548 151675637 90 - 1.098 1.047 -0.187
ENSG00000106617 E055 0.0000000       7 151734248 151734311 64 -      
ENSG00000106617 E056 0.6589510 0.0479603794 1.426449e-01 2.516379e-01 7 151735900 151736314 415 - 0.097 0.355 2.333
ENSG00000106617 E057 0.9921708 0.1525892732 2.131328e-01 3.422448e-01 7 151751226 151753237 2012 - 0.177 0.429 1.745
ENSG00000106617 E058 0.4460135 0.0503934434 2.032411e-01 3.302832e-01 7 151781126 151781151 26 - 0.244 0.000 -13.386
ENSG00000106617 E059 16.0944521 0.0010966379 4.482278e-01 5.895307e-01 7 151781152 151781284 133 - 1.199 1.272 0.259
ENSG00000106617 E060 12.0856471 0.0044782145 3.530627e-01 4.973024e-01 7 151781285 151781431 147 - 1.072 1.173 0.366
ENSG00000106617 E061 7.1789629 0.0515388337 3.381743e-01 4.820588e-01 7 151786470 151786541 72 - 0.831 0.980 0.563
ENSG00000106617 E062 0.0000000       7 151790500 151790880 381 -      
ENSG00000106617 E063 0.0000000       7 151790881 151791000 120 -      
ENSG00000106617 E064 0.0000000       7 151813520 151813732 213 -      
ENSG00000106617 E065 0.0000000       7 151814416 151815024 609 -      
ENSG00000106617 E066 4.5640912 0.0036889170 1.166736e-06 9.553298e-06 7 151837268 151837495 228 - 0.302 1.012 3.210
ENSG00000106617 E067 40.1503457 0.0131648449 3.781185e-03 1.252928e-02 7 151876507 151877125 619 - 1.503 1.721 0.741