ENSG00000106603

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000223336 ENSG00000106603 HEK293_OSMI2_2hA HEK293_TMG_2hB COA1 protein_coding protein_coding 85.44342 100.7076 82.06676 19.18006 2.043132 -0.2952705 67.201092 86.1013720 57.678228 18.3814444 1.9879239 -0.5779268 0.7783583 0.845966667 0.70246667 -0.14350000 1.601475e-03 1.500701e-11 FALSE TRUE
ENST00000438444 ENSG00000106603 HEK293_OSMI2_2hA HEK293_TMG_2hB COA1 protein_coding nonsense_mediated_decay 85.44342 100.7076 82.06676 19.18006 2.043132 -0.2952705 2.535914 0.4766642 4.560383 0.1068086 0.3463904 3.2313165 0.0310250 0.005166667 0.05563333 0.05046667 2.381523e-10 1.500701e-11 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106603 E001 0.4782907 0.0217681645 1.362734e-01 2.428517e-01 7 43608456 43608460 5 - 0.000 0.270 10.926
ENSG00000106603 E002 59.9996044 0.0004316319 7.098943e-02 1.449826e-01 7 43608461 43608818 358 - 1.822 1.753 -0.234
ENSG00000106603 E003 85.0086623 0.0014247828 4.228612e-07 3.795773e-06 7 43608819 43609232 414 - 2.040 1.841 -0.669
ENSG00000106603 E004 33.0767832 0.0041309980 2.223917e-03 7.917602e-03 7 43609233 43609297 65 - 1.636 1.443 -0.661
ENSG00000106603 E005 55.4006832 0.0079936513 1.623695e-05 1.028157e-04 7 43609298 43609495 198 - 1.889 1.617 -0.920
ENSG00000106603 E006 35.3711224 0.0244896104 6.112568e-03 1.890470e-02 7 43609496 43609641 146 - 1.695 1.421 -0.936
ENSG00000106603 E007 27.3293779 0.0937818976 1.790522e-06 1.407565e-05 7 43631012 43631151 140 - 1.754 0.928 -2.901
ENSG00000106603 E008 15.7207387 0.0231727573 1.279674e-11 2.618322e-10 7 43631152 43631183 32 - 1.527 0.704 -3.010
ENSG00000106603 E009 49.5376250 0.0019996020 3.617114e-48 1.997817e-45 7 43631184 43631468 285 - 2.016 1.154 -2.955
ENSG00000106603 E010 19.5700547 0.0009084463 8.832174e-21 6.210946e-19 7 43631469 43631480 12 - 1.609 0.848 -2.712
ENSG00000106603 E011 61.5415390 0.0004111962 8.236378e-67 1.091159e-63 7 43631481 43631782 302 - 2.108 1.255 -2.902
ENSG00000106603 E012 37.5732573 0.0582110339 1.877935e-12 4.400904e-11 7 43631783 43632224 442 - 1.919 0.907 -3.533
ENSG00000106603 E013 98.2891796 0.0198888238 2.249673e-33 4.887543e-31 7 43632225 43633278 1054 - 2.335 1.291 -3.536
ENSG00000106603 E014 31.2198740 0.0666708713 7.464570e-11 1.343984e-09 7 43633279 43633408 130 - 1.839 0.839 -3.524
ENSG00000106603 E015 5.3392456 0.0035679522 1.234186e-05 8.028186e-05 7 43638799 43639130 332 - 1.052 0.480 -2.350
ENSG00000106603 E016 3.9731944 0.0041778627 1.750523e-05 1.099938e-04 7 43639131 43639256 126 - 0.958 0.333 -2.809
ENSG00000106603 E017 10.9742781 0.0074201659 3.606872e-04 1.621526e-03 7 43639257 43639280 24 - 0.788 1.216 1.585
ENSG00000106603 E018 92.7568533 0.0134578514 6.338395e-09 8.116736e-08 7 43639281 43639355 75 - 1.671 2.089 1.410
ENSG00000106603 E019 483.7920909 0.0068967075 6.335011e-04 2.656725e-03 7 43639356 43639448 93 - 2.578 2.734 0.518
ENSG00000106603 E020 1299.6184034 0.0019617696 2.551993e-03 8.917925e-03 7 43639449 43639681 233 - 3.066 3.132 0.220
ENSG00000106603 E021 773.9042892 0.0001080264 3.963765e-04 1.760376e-03 7 43640573 43640649 77 - 2.853 2.911 0.193
ENSG00000106603 E022 5.8777427 0.0070903019 6.709180e-02 1.385263e-01 7 43640650 43641069 420 - 0.670 0.928 1.025
ENSG00000106603 E023 2.9706148 0.1159927740 4.201714e-02 9.475200e-02 7 43641446 43642164 719 - 0.789 0.427 -1.622
ENSG00000106603 E024 1003.9597710 0.0004734982 8.402732e-06 5.680187e-05 7 43645251 43645399 149 - 2.956 3.024 0.227
ENSG00000106603 E025 3.8333297 0.0064141324 2.496079e-02 6.179026e-02 7 43645400 43645417 18 - 0.837 0.519 -1.349
ENSG00000106603 E026 18.1673016 0.0022583915 1.337637e-05 8.629118e-05 7 43645418 43646296 879 - 1.450 1.108 -1.202
ENSG00000106603 E027 10.7583499 0.0232125458 9.784764e-01 9.906499e-01 7 43646297 43646471 175 - 1.066 1.081 0.055
ENSG00000106603 E028 9.7048824 0.0020030142 6.667614e-01 7.741656e-01 7 43646472 43646581 110 - 1.053 1.021 -0.114
ENSG00000106603 E029 13.3557885 0.0013138417 6.141547e-07 5.338859e-06 7 43646582 43647215 634 - 1.369 0.929 -1.581
ENSG00000106603 E030 2.5691613 0.0261294513 3.292545e-02 7.765658e-02 7 43647216 43647227 12 - 0.733 0.387 -1.617
ENSG00000106603 E031 2.4198360 0.0177719382 4.856513e-02 1.066195e-01 7 43647228 43647274 47 - 0.702 0.387 -1.490
ENSG00000106603 E032 2.6914302 0.0253958457 1.401826e-01 2.482782e-01 7 43647275 43647350 76 - 0.702 0.477 -1.013
ENSG00000106603 E033 3.8705803 0.0851258775 3.021895e-02 7.240006e-02 7 43647351 43647534 184 - 0.881 0.511 -1.557
ENSG00000106603 E034 730.3192240 0.0009246376 1.984545e-03 7.178489e-03 7 43647535 43647634 100 - 2.822 2.883 0.203
ENSG00000106603 E035 3.5916097 0.0552333823 8.757698e-02 1.714587e-01 7 43647635 43648187 553 - 0.813 0.519 -1.257
ENSG00000106603 E036 1.0641663 0.1567520107 2.208901e-01 3.514987e-01 7 43648188 43648599 412 - 0.452 0.197 -1.679
ENSG00000106603 E037 512.6535997 0.0002833134 3.891578e-02 8.902776e-02 7 43648600 43648652 53 - 2.682 2.728 0.155
ENSG00000106603 E038 5.5036079 0.1417998662 2.731879e-01 4.121872e-01 7 43648653 43650296 1644 - 0.941 0.696 -0.963
ENSG00000106603 E039 13.8139826 0.0014514685 5.379923e-01 6.694716e-01 7 43650493 43650611 119 - 1.196 1.154 -0.149
ENSG00000106603 E040 64.7266570 0.0010222636 3.873153e-03 1.278679e-02 7 43650612 43650712 101 - 1.885 1.767 -0.396
ENSG00000106603 E041 1.6972939 0.0094825067 6.779726e-01 7.825458e-01 7 43651750 43651829 80 - 0.453 0.388 -0.348
ENSG00000106603 E042 0.4428904 0.8738027015 4.751417e-01 6.138869e-01 7 43652090 43652138 49 - 0.000 0.211 11.146
ENSG00000106603 E043 0.3686942 0.0516388608 8.610277e-01 9.143721e-01 7 43656033 43656153 121 - 0.136 0.110 -0.344
ENSG00000106603 E044 2.8794878 0.0053183198 7.214357e-01 8.158219e-01 7 43657216 43657221 6 - 0.553 0.620 0.301
ENSG00000106603 E045 2.8816779 0.0055902205 7.213153e-01 8.157423e-01 7 43657222 43657269 48 - 0.553 0.620 0.301
ENSG00000106603 E046 5.1134456 0.0361759567 1.926811e-02 4.991572e-02 7 43658712 43659144 433 - 0.506 0.885 1.598
ENSG00000106603 E047 85.7369618 0.0135217648 2.045818e-01 3.318896e-01 7 43665658 43665722 65 - 1.882 1.957 0.251
ENSG00000106603 E048 2.5452108 0.0135405623 9.555087e-01 9.760893e-01 7 43711400 43711449 50 - 0.553 0.555 0.009
ENSG00000106603 E049 412.6122918 0.0007341663 2.131408e-03 7.631617e-03 7 43729429 43729717 289 - 2.568 2.642 0.247