ENSG00000106526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000252071 ENSG00000106526 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR3C protein_coding protein_coding 0.7569526 0.8928569 0.8274233 0.172743 0.09588937 -0.1085402 0.06786203 0.102966831 0.00000000 0.102966831 0.000000000 -3.497827 0.08659167 0.08850000 0.00000000 -0.0885000 0.74104666 0.01365503 FALSE TRUE
ENST00000613959 ENSG00000106526 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR3C protein_coding protein_coding 0.7569526 0.8928569 0.8274233 0.172743 0.09588937 -0.1085402 0.02639649 0.008303812 0.05200524 0.008303812 0.009431683 1.760246 0.04073750 0.01453333 0.06703333 0.0525000 0.31347835 0.01365503 FALSE FALSE
ENST00000683684 ENSG00000106526 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR3C protein_coding protein_coding 0.7569526 0.8928569 0.8274233 0.172743 0.09588937 -0.1085402 0.11667055 0.246196973 0.00000000 0.134541256 0.000000000 -4.679182 0.15896667 0.32423333 0.00000000 -0.3242333 0.19764194 0.01365503 FALSE TRUE
MSTRG.30919.5 ENSG00000106526 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR3C protein_coding   0.7569526 0.8928569 0.8274233 0.172743 0.09588937 -0.1085402 0.08632567 0.071492006 0.02486155 0.009858794 0.024861554 -1.225022 0.12800000 0.09136667 0.03686667 -0.0545000 0.60146675 0.01365503 FALSE TRUE
MSTRG.30919.6 ENSG00000106526 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR3C protein_coding   0.7569526 0.8928569 0.8274233 0.172743 0.09588937 -0.1085402 0.38028905 0.285839679 0.55980392 0.053970713 0.110989076 0.945650 0.49372917 0.32430000 0.66463333 0.3403333 0.01365503 0.01365503 FALSE TRUE
MSTRG.30919.8 ENSG00000106526 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR3C protein_coding   0.7569526 0.8928569 0.8274233 0.172743 0.09588937 -0.1085402 0.02756133 0.000000000 0.09629950 0.000000000 0.054616283 3.410063 0.03522500 0.00000000 0.10416667 0.1041667 0.14335753 0.01365503 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106526 E001 0.1451727 0.047978909 3.593642e-01   7 150243916 150243918 3 - 0.139 0.000 -12.268
ENSG00000106526 E002 2.5422964 0.024710564 4.663529e-06 3.342993e-05 7 150243919 150247211 3293 - 0.846 0.108 -4.415
ENSG00000106526 E003 0.1515154 0.044546531 3.603244e-01   7 150247212 150247212 1 - 0.139 0.000 -12.271
ENSG00000106526 E004 3.0664751 0.006221629 9.141380e-02 1.773411e-01 7 150247213 150247569 357 - 0.399 0.694 1.391
ENSG00000106526 E005 1.4714926 0.010060402 4.974798e-02 1.087142e-01 7 150247570 150248947 1378 - 0.139 0.512 2.582
ENSG00000106526 E006 2.6172394 0.006451638 1.193488e-04 6.108903e-04 7 150248948 150249054 107 - 0.000 0.718 15.069
ENSG00000106526 E007 0.1817044 0.084693690 6.468605e-01   7 150249055 150249060 6 - 0.000 0.108 11.165
ENSG00000106526 E008 0.1482932 0.041159753 6.540359e-01   7 150264770 150264874 105 - 0.000 0.108 11.160
ENSG00000106526 E009 0.3332198 0.033313160 8.001076e-01   7 150266755 150266910 156 - 0.139 0.108 -0.415
ENSG00000106526 E010 0.1482932 0.041159753 6.540359e-01   7 150284747 150284752 6 - 0.000 0.108 11.160
ENSG00000106526 E011 0.8146179 0.017801880 4.592372e-02 1.018972e-01 7 150284753 150284762 10 - 0.000 0.381 13.481
ENSG00000106526 E012 3.0310022 0.005807112 4.095494e-01 5.531562e-01 7 150284763 150284845 83 - 0.513 0.668 0.697
ENSG00000106526 E013 5.7225697 0.025002028 5.809761e-01 7.056096e-01 7 150286367 150286467 101 - 0.770 0.869 0.389
ENSG00000106526 E014 4.3962353 0.004557949 9.942260e-01 1.000000e+00 7 150286468 150286540 73 - 0.711 0.741 0.123
ENSG00000106526 E015 4.3252614 0.004557949 4.245080e-01 5.674654e-01 7 150289450 150289593 144 - 0.770 0.694 -0.310
ENSG00000106526 E016 3.4457825 0.005117639 3.589212e-01 5.032829e-01 7 150293312 150293419 108 - 0.711 0.612 -0.418
ENSG00000106526 E017 2.9245287 0.006102283 2.770652e-01 4.165741e-01 7 150295252 150295305 54 - 0.677 0.548 -0.571
ENSG00000106526 E018 2.6946499 0.006451638 5.808029e-01 7.055012e-01 7 150295306 150295343 38 - 0.603 0.548 -0.248
ENSG00000106526 E019 1.7347575 0.010457462 7.364484e-01 8.269396e-01 7 150295344 150295347 4 - 0.459 0.429 -0.155
ENSG00000106526 E020 0.0000000       7 150302842 150302980 139 -      
ENSG00000106526 E021 2.0952467 0.239510974 7.862106e-01 8.630905e-01 7 150322866 150323163 298 - 0.512 0.441 -0.354
ENSG00000106526 E022 1.9301784 0.037907851 6.578004e-01 7.670944e-01 7 150323469 150323725 257 - 0.399 0.510 0.573