ENSG00000106524

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306999 ENSG00000106524 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKMY2 protein_coding protein_coding 5.406388 2.366345 8.32124 0.06981975 0.3171054 1.809787 5.195911 2.34799 7.54661 0.05278737 0.3105339 1.680182 0.9609 0.9926667 0.9074667 -0.0852 0.01244577 0.008180703 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106524 E001 0.1817044 0.0402361435 0.1540642838   7 16599779 16599781 3 - 0.000 0.199 10.474
ENSG00000106524 E002 163.9769366 0.0053571657 0.0001081786 0.0005596883 7 16599782 16600945 1164 - 2.120 2.278 0.530
ENSG00000106524 E003 49.0521087 0.0009044042 0.5300994415 0.6627887334 7 16602380 16602509 130 - 1.652 1.642 -0.033
ENSG00000106524 E004 0.7416694 0.0169673980 0.8028473012 0.8744474239 7 16603549 16603645 97 - 0.238 0.198 -0.337
ENSG00000106524 E005 0.4386386 0.1259801226 0.7401925751 0.8296734774 7 16603646 16603660 15 - 0.135 0.197 0.656
ENSG00000106524 E006 38.0403312 0.0005496167 0.1006832246 0.1915035326 7 16604721 16604849 129 - 1.564 1.485 -0.271
ENSG00000106524 E007 34.9083930 0.0006701362 0.0145801875 0.0395449152 7 16609630 16609765 136 - 1.544 1.404 -0.483
ENSG00000106524 E008 48.3198979 0.0005741235 0.0080883474 0.0240035271 7 16610549 16610763 215 - 1.679 1.553 -0.429
ENSG00000106524 E009 38.0662680 0.0007512201 0.6563754325 0.7659771997 7 16615744 16615904 161 - 1.549 1.546 -0.008
ENSG00000106524 E010 16.3214333 0.0330876532 0.7176074125 0.8129290958 7 16624983 16625041 59 - 1.173 1.249 0.266
ENSG00000106524 E011 17.9470016 0.0010737081 0.5021603755 0.6382394193 7 16625042 16625081 40 - 1.242 1.206 -0.127
ENSG00000106524 E012 21.6935489 0.0010612007 0.8703997993 0.9206435825 7 16627040 16627090 51 - 1.305 1.316 0.038
ENSG00000106524 E013 26.2360552 0.0007918510 0.9841358294 0.9941748188 7 16627091 16627178 88 - 1.381 1.404 0.079
ENSG00000106524 E014 24.4730953 0.0008699922 0.9479320543 0.9712748945 7 16636391 16636455 65 - 1.354 1.373 0.067
ENSG00000106524 E015 0.4783925 0.0208658954 0.7356591174 0.8263569961 7 16644626 16644669 44 - 0.135 0.199 0.664
ENSG00000106524 E016 0.4783925 0.0208658954 0.7356591174 0.8263569961 7 16644670 16644684 15 - 0.135 0.199 0.664
ENSG00000106524 E017 1.8059375 0.0078278423 0.1388694994 0.2465481183 7 16644685 16644812 128 - 0.479 0.198 -1.795
ENSG00000106524 E018 34.8635615 0.0007142301 0.1131205585 0.2100870572 7 16645507 16645817 311 - 1.530 1.451 -0.273