ENSG00000106399

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396682 ENSG00000106399 HEK293_OSMI2_2hA HEK293_TMG_2hB RPA3 protein_coding protein_coding 80.3994 82.83926 102.2417 18.42236 3.404272 0.3035638 43.758214 52.00524 54.16396 12.624656 0.7526277 0.05866507 0.55417083 0.6215 0.5309333 -0.09056667 1.162142e-01 4.764192e-26 FALSE TRUE
ENST00000401447 ENSG00000106399 HEK293_OSMI2_2hA HEK293_TMG_2hB RPA3 protein_coding protein_coding 80.3994 82.83926 102.2417 18.42236 3.404272 0.3035638 8.269912 0.00000 12.35193 0.000000 2.8789392 10.27168860 0.09743333 0.0000 0.1198667 0.11986667 4.764192e-26 4.764192e-26   FALSE
MSTRG.29492.2 ENSG00000106399 HEK293_OSMI2_2hA HEK293_TMG_2hB RPA3 protein_coding   80.3994 82.83926 102.2417 18.42236 3.404272 0.3035638 23.951635 26.76887 30.67982 6.023516 1.4798812 0.19666524 0.29247917 0.3237 0.2999000 -0.02380000 5.781158e-01 4.764192e-26   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106399 E001 19.381135 0.0020867113 2.071146e-04 9.945059e-04 7 7636518 7636758 241 - 1.447 1.161 -0.999
ENSG00000106399 E002 212.433190 0.0025173002 3.422235e-03 1.150341e-02 7 7636759 7636926 168 - 2.384 2.286 -0.327
ENSG00000106399 E003 156.306175 0.0067129793 3.431811e-01 4.872529e-01 7 7636927 7636931 5 - 2.227 2.172 -0.182
ENSG00000106399 E004 389.263187 0.0015994268 6.546380e-01 7.647554e-01 7 7636932 7636974 43 - 2.588 2.598 0.035
ENSG00000106399 E005 340.889993 0.0004246543 9.158214e-02 1.776040e-01 7 7636975 7636984 10 - 2.515 2.557 0.141
ENSG00000106399 E006 823.106279 0.0008511406 4.406801e-01 5.823569e-01 7 7636985 7637082 98 - 2.910 2.928 0.061
ENSG00000106399 E007 1193.833979 0.0013702185 8.179443e-01 8.848876e-01 7 7637864 7637972 109 - 3.074 3.082 0.026
ENSG00000106399 E008 11.470527 0.0057689545 3.438770e-02 8.049829e-02 7 7637973 7638406 434 - 1.200 0.991 -0.756
ENSG00000106399 E009 3.946012 0.0056210709 1.175488e-04 6.026052e-04 7 7638414 7638578 165 - 0.925 0.353 -2.563
ENSG00000106399 E010 11.694129 0.0145017132 2.302341e-04 1.092641e-03 7 7638579 7639069 491 - 1.283 0.863 -1.531
ENSG00000106399 E011 1047.321764 0.0001881365 3.359870e-01 4.798078e-01 7 7639070 7639144 75 - 3.028 3.026 -0.007
ENSG00000106399 E012 3.855470 0.0039960352 1.355914e-05 8.736312e-05 7 7639905 7640026 122 - 0.942 0.288 -3.043
ENSG00000106399 E013 900.894571 0.0018220789 4.632525e-01 6.030744e-01 7 7640320 7640581 262 - 2.949 2.960 0.036
ENSG00000106399 E014 7.765472 0.1196376557 3.323751e-02 7.826906e-02 7 7640582 7640722 141 - 0.674 1.064 1.511
ENSG00000106399 E015 17.950447 0.0582874019 1.420883e-03 5.376220e-03 7 7640723 7641175 453 - 0.975 1.412 1.557
ENSG00000106399 E016 0.000000       7 7685830 7685998 169 -      
ENSG00000106399 E017 0.000000       7 7687228 7687328 101 -      
ENSG00000106399 E018 0.000000       7 7715175 7715226 52 -      
ENSG00000106399 E019 0.000000       7 7718515 7718607 93 -