ENSG00000106355

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409292 ENSG00000106355 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM5 protein_coding protein_coding 109.2298 116.5998 127.6659 14.00091 7.112729 0.1307974 55.718860 72.031750 50.459174 8.2172369 4.7178225 -0.5134307 0.51937083 0.61920000 0.39346667 -0.22573333 2.631491e-07 2.112827e-10   FALSE
ENST00000409909 ENSG00000106355 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM5 protein_coding protein_coding 109.2298 116.5998 127.6659 14.00091 7.112729 0.1307974 15.749031 11.695116 31.308695 3.4409793 1.7216252 1.4198848 0.13576250 0.09723333 0.24530000 0.14806667 2.232475e-03 2.112827e-10   FALSE
ENST00000409987 ENSG00000106355 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM5 protein_coding protein_coding 109.2298 116.5998 127.6659 14.00091 7.112729 0.1307974 7.926607 12.090462 6.472378 1.5213628 0.4032961 -0.9004670 0.07433750 0.10376667 0.05066667 -0.05310000 2.112827e-10 2.112827e-10   FALSE
ENST00000450169 ENSG00000106355 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM5 protein_coding protein_coding 109.2298 116.5998 127.6659 14.00091 7.112729 0.1307974 7.933984 5.389482 14.227158 1.1656462 0.6608456 1.3987682 0.06697917 0.04530000 0.11160000 0.06630000 1.017958e-09 2.112827e-10   FALSE
MSTRG.29683.4 ENSG00000106355 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM5 protein_coding   109.2298 116.5998 127.6659 14.00091 7.112729 0.1307974 17.042580 13.203538 18.529885 0.4651609 0.2609094 0.4886155 0.15826250 0.11560000 0.14633333 0.03073333 3.534435e-01 2.112827e-10   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000106355 E001 289.550745 3.295318e-03 2.062611e-14 6.481264e-13 7 32485338 32486804 1467 - 2.582 2.314 -0.894
ENSG00000106355 E002 112.472525 9.901474e-03 4.267462e-10 6.767603e-09 7 32486805 32486867 63 - 2.209 1.831 -1.270
ENSG00000106355 E003 192.491226 1.645707e-03 6.230218e-18 3.129099e-16 7 32486868 32487028 161 - 2.413 2.127 -0.955
ENSG00000106355 E004 89.614734 7.439952e-04 4.077974e-08 4.478518e-07 7 32487029 32487034 6 - 2.063 1.841 -0.745
ENSG00000106355 E005 91.033027 3.406457e-03 2.050850e-02 5.256112e-02 7 32487035 32487039 5 - 2.024 1.914 -0.369
ENSG00000106355 E006 174.667815 2.796688e-04 6.590395e-01 7.679673e-01 7 32487040 32487062 23 - 2.260 2.239 -0.068
ENSG00000106355 E007 154.344725 2.027400e-03 2.690466e-01 4.075194e-01 7 32487063 32487064 2 - 2.182 2.209 0.089
ENSG00000106355 E008 1301.856442 1.225814e-04 3.343738e-42 1.330801e-39 7 32487065 32487293 229 - 3.055 3.177 0.404
ENSG00000106355 E009 16.108101 2.253232e-03 2.421095e-01 3.766870e-01 7 32487294 32487684 391 - 1.187 1.279 0.322
ENSG00000106355 E010 1113.211195 9.388925e-05 7.094380e-12 1.514035e-10 7 32487685 32487757 73 - 3.020 3.081 0.204
ENSG00000106355 E011 54.485089 4.341433e-04 1.120428e-16 4.786058e-15 7 32487758 32488624 867 - 1.912 1.486 -1.444
ENSG00000106355 E012 744.864700 1.158499e-04 6.350534e-02 1.325324e-01 7 32488625 32488652 28 - 2.893 2.861 -0.108
ENSG00000106355 E013 12.215323 3.086432e-03 4.399575e-01 5.816779e-01 7 32489234 32489248 15 - 1.083 1.148 0.236
ENSG00000106355 E014 881.678951 1.568328e-04 9.114103e-01 9.477540e-01 7 32489249 32489344 96 - 2.955 2.944 -0.036
ENSG00000106355 E015 4.099629 3.931822e-03 1.321997e-02 3.642410e-02 7 32489464 32489600 137 - 0.863 0.494 -1.573
ENSG00000106355 E016 9.203330 6.872382e-03 1.809930e-02 4.734488e-02 7 32490025 32490130 106 - 1.124 0.846 -1.033
ENSG00000106355 E017 17.333189 7.593402e-03 4.862349e-02 1.067204e-01 7 32490131 32490319 189 - 1.348 1.159 -0.665
ENSG00000106355 E018 460.223967 2.125736e-04 3.428729e-01 4.869101e-01 7 32490320 32490591 272 - 2.680 2.655 -0.084
ENSG00000106355 E019 3.137531 3.810298e-02 2.076212e-01 3.356276e-01 7 32490592 32490759 168 - 0.716 0.494 -0.988
ENSG00000106355 E020 1.542659 7.184323e-02 3.777472e-01 5.220534e-01 7 32490760 32490863 104 - 0.491 0.313 -0.989
ENSG00000106355 E021 2.845325 5.432657e-03 4.355693e-02 9.756734e-02 7 32494856 32494921 66 - 0.716 0.383 -1.571
ENSG00000106355 E022 4.311713 4.069957e-03 5.342685e-04 2.288030e-03 7 32494991 32495229 239 - 0.914 0.383 -2.349
ENSG00000106355 E023 8.414240 2.073347e-03 3.951419e-01 5.389697e-01 7 32495230 32495283 54 - 1.025 0.925 -0.373